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Membrane-Associated Ring Finger (C3HC4) 1, E3 Ubiquitin Protein Ligase Proteins (MARCH1)

MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). Additionally we are shipping MARCH1 Antibodies (49) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MARCH1 72925 Q6NZQ8
MARCH1 55016 Q8TCQ1
Rat MARCH1 MARCH1 361135  
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Top MARCH1 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

MARCH1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for Membrane-Associated Ring Finger (C3HC4) 1, E3 Ubiquitin Protein Ligase (MARCH1) Interaction Partners

Mouse (Murine) Membrane-Associated Ring Finger (C3HC4) 1, E3 Ubiquitin Protein Ligase (MARCH1) interaction partners

  1. March-I ubiquitination prevents MHC class II recycling and promotes MHC class II turnover in antigen-presenting cells

  2. IL-10 (show IL10 Proteins) stimulates expression of the E3 ubiquitin ligase (show MUL1 Proteins) March-I in activated macrophages, thereby down-regulating MHC-II, CD86 (show CD86 Proteins), and antigen presentation to CD4 (show CD4 Proteins) T cells.

  3. Dendritic cells co-cultivated with antigen-specific induced Tregs expressed high levels of MARCH1. A major suppressive mechanism of DC function by iTregs is secondary to the effects of IL-10 (show IL10 Proteins) on MARCH1 & CD83 (show CD83 Proteins) expression.

  4. DCs deficient in MARCH1 or MHCII ubiquitination both failed to generate antigen-specific T reg (show KCNH2 Proteins) cells in vivo and in vitro.

  5. aberrant degradation of spleen DCs MARCH1-mediated ubiquitinated proteins is involved during the earliest stage of MODS development.

  6. IL-10 can have opposite effects on MARCH1 regulation in different cell types.

  7. Ubiquitin-mediated regulation of CD86 protein expression by the ubiquitin ligase membrane-associated RING-CH-1 (MARCH1).

  8. found that the transmembrane domain of CD83 enhances MHC class II and CD86 expression by blocking MHC class II association with the ubiquitin ligase MARCH1

  9. Selective ubiquitination of MHC-II in immature dendritic cells by the E3 ubiquitin ligase (show MUL1 Proteins) March-I results in the selective degradation of internalized pMHC-II.

  10. The function of MHC II in B cells is regulated through ubiquitination by MARCH-I.

Human Membrane-Associated Ring Finger (C3HC4) 1, E3 Ubiquitin Protein Ligase (MARCH1) interaction partners

  1. findings highlight the complex regulation of MARCH1 trafficking in the endocytic pathway as well as the intricate interactions between its cytoplasmic tails.

  2. MARCH1 is capable of autoubiquitination, thus regulating its own expression.

  3. expression of MARCH1 or MARCH8 causes a drastic change CD98 trafficking after endocytosis

  4. MARCH I is a major regulator of HLA-DR traffic, and its loss contributes to the acquisition of the potent immunostimulatory properties of mature human DCs.

  5. The immunosuppressive effect of IL-10 on antigen presentation is mediated through induced expression of MARCH1.

MARCH1 Protein Profile

Protein Summary

MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004

Gene names and symbols associated with MARCH1

  • membrane-associated ring finger (C3HC4) 1 (March1)
  • membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase (MARCH1)
  • membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase (March1)
  • 2900024D24Rik protein
  • BB085186 protein
  • MARCH-I protein
  • RGD1305148 protein
  • RNF171 protein

Protein level used designations for MARCH1

E3 ubiquitin-protein ligase MARCH1 , MARCH-I , membrane-associated RING finger protein 1 , membrane-associated RING-CH protein I , RING finger protein 171

GENE ID SPECIES
72925 Mus musculus
55016 Homo sapiens
361135 Rattus norvegicus
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