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Membrane-Associated Ring Finger (C3HC4) 8, E3 Ubiquitin Protein Ligase Proteins (MARCH8)

MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). Additionally we are shipping MARCH8 Antibodies (40) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MARCH8 71779 Q9DBD2
MARCH8 220972 Q5T0T0
Rat MARCH8 MARCH8 312656  
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Top MARCH8 Proteins at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

MARCH8 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for Membrane-Associated Ring Finger (C3HC4) 8, E3 Ubiquitin Protein Ligase (MARCH8) Interaction Partners

Zebrafish Membrane-Associated Ring Finger (C3HC4) 8, E3 Ubiquitin Protein Ligase (MARCH8) interaction partners

  1. March 8 functions in the embryo to modulate the strength of cell adhesion by regulating the localization of E-cadherin (show CDH1 Proteins).

Human Membrane-Associated Ring Finger (C3HC4) 8, E3 Ubiquitin Protein Ligase (MARCH8) interaction partners

  1. MARCH8 is highly expressed in terminally differentiated myeloid cells, and that it is a potent antiviral protein that targets viral envelope glycoproteins and reduces their incorporation into virions.

  2. MARCH 8 mediates the ubiquitination and lysosomal degradation of the transferrin receptor.

  3. MARCH8 protein localizes in lysosomes in HeLa cells

  4. endogenous MARCH-8 regulates the steady-state cell surface expression of TRAIL-R1.

  5. MARCH8-mediated polyubiquitination and degradation of IL1RAP (show IL1RAP Proteins) is an important mechanism for negative regulation of IL-1beta (show IL1B Proteins)-induced signaling pathways.

  6. MARCH8 expression led to direct ubiquitination of CD98 and routing of CD98 to late endosomes/lysosomes

  7. Membrane-Associated RING-CH proteins MARCH VIII and MARCH IV (show MARCH4 Proteins) associate with Bap31 (show BCAP31 Proteins) and target CD81 (show CD81 Proteins) and CD44 (show CD44 Proteins) to lysosomes

  8. c-MIR induced specific down-regulation of B7-2 (show CD86 Proteins) surface expression through ubiquitination, rapid endocytosis, and lysosomal degradation

  9. Of the classifier's 11 informative genes, expression of MIR (show MLXIP Proteins) and WDR40 showed statistically significant increases for both Grade 1B and Grade >or=3A rejection.

MARCH8 Protein Profile

Protein Summary

MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins (Goto et al., 2003

Gene names and symbols associated with MARCH8

  • membrane-associated ring finger (C3HC4) 8 (March8)
  • membrane-associated ring finger (C3HC4) 8 (march8)
  • membrane-associated ring finger (C3HC4) 8 (MARCH8)
  • membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase (MARCH8)
  • membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase (March8)
  • membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase (march8)
  • 1300017E09Rik protein
  • c-MIR protein
  • Mar-08 protein
  • MARCH-VIII protein
  • MIR protein
  • RNF178 protein
  • zgc:171495 protein

Protein level used designations for MARCH8

E3 ubiquitin-protein ligase MARCH8 , MARCH-VIII , c-mir, cellular modulator of immune recognition , cellular modulator of immune recognition , membrane-associated RING finger protein 8 , membrane-associated RING-CH protein VIII , RING finger protein 178 , cellular modulator of immune recognition (c-MIR)

GENE ID SPECIES
71779 Mus musculus
567818 Danio rerio
540667 Bos taurus
220972 Homo sapiens
312656 Rattus norvegicus
495072 Xenopus laevis
423770 Gallus gallus
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