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Meningioma Expressed Antigen 5 (Hyaluronidase) Proteins (MGEA5)

The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008].. Additionally we are shipping MGEA5 Antibodies (38) and MGEA5 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MGEA5 10724 O60502
MGEA5 76055 Q9EQQ9
Rat MGEA5 MGEA5 154968 Q8VIJ5
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Top MGEA5 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

MGEA5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Meningioma Expressed Antigen 5 (Hyaluronidase) (MGEA5) Interaction Partners

Human Meningioma Expressed Antigen 5 (Hyaluronidase) (MGEA5) interaction partners

  1. E2F1 (show E2F1 Proteins) negatively regulates both Ogt (show OGT Proteins) and Mgea5 expression in an Rb1 (show RB1 Proteins) protein-dependent manner.

  2. OGA overexpression in endothelial cells improves endothelial function and may have a beneficial effect on coronary vascular complications in diabetes.

  3. Amino acid composition of splice variants, post-translational modifications, and stable associations with regulatory proteins influence subcellular distribution/substrate specificity of OGA and OGT (O-linked N-acetylglucosamine transferase (show OGT Proteins)). [REVIEW]

  4. This work identifies the first target of miR (show MLXIP Proteins)-539 in the heart and the first miRNA that regulates OGA.

  5. Report the presence of TGFBR3 (show TGFBR3 Proteins) and/or MGEA5 rearrangements in pleomorphic hyalinizing angiectatic tumors and the spectrum of related neoplasms.

  6. Estrogen replacement therapy and plyometric training influence muscle OGT and OGA gene expression, which may be one of the mechanisms by which HRT and PT prevent aging-related loss of muscle mass.

  7. O-linked beta-N-acetylglucosaminylation (O-GlcNAcylation) in primary and metastatic colorectal cancer clones and effect of N-acetyl-beta-D-glucosaminidase silencing on cell phenotype and transcriptome.

  8. Data show that the interplay between O-GlcNAc (show OGT Proteins) and phosphorylation on proteins and indicate that these effects can be mediated by changes in hOGT and hOGA (show OAT Proteins) kinetic activity.

  9. Analysis of urinary content of MGEA5 and OGT (show OGT Proteins) may be useful for bladder cancer diagnostics.

  10. Decrease in MGEA5 and increase in O-GlcNAc transferease expression in higher grade tumors suggests that increased O-GlcNAc modification may be implicated in breast tumor progression and metastasis.

Mouse (Murine) Meningioma Expressed Antigen 5 (Hyaluronidase) (MGEA5) interaction partners

  1. Oga(+/-) mice resist high-fat diet-induced obesity with ameliorated hepatic steatosis and improved glucose metabolism

  2. plays a critical role in placental vasculogenesis by modulating HIF-1alpha (show HIF1A Proteins) stabilization

  3. E2F1 (show E2F1 Proteins) negatively regulates both Ogt (show OGT Proteins) and Mgea5 expression in an Rb1 (show RB1 Proteins) protein-dependent manner.

  4. Conditional disruption of the O-GlcNAcase in mice leads to metabolic deregulation and semi-penetrant perinatal lethality.

  5. This work identifies the first target of miR (show MLXIP Proteins)-539 in the heart and the first miRNA that regulates OGA.

  6. The O-GlcNAcase active site resembles those of glycosidases which carry out the hydrolysis of GlcNAc linkages in a substrate-assisted acid-base manner.

Pig (Porcine) Meningioma Expressed Antigen 5 (Hyaluronidase) (MGEA5) interaction partners

  1. Data suggest that enzymes in hexosamine biosynthesis pathway and downstream protein O-GlcNAcylation are important for preimplantation development; these include Oga, Gfpt (glutamine-fructose-6-P aminotransferase), and Ogt (O-GlcNAc transferase).

MGEA5 Protein Profile

Protein Summary

The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001

Gene names and symbols associated with MGEA5

  • meningioma expressed antigen 5 (hyaluronidase) (MGEA5)
  • meningioma expressed antigen 5 (hyaluronidase) (Mgea5)
  • 2810009A20Rik protein
  • 4833427O07Rik protein
  • 5830447M11Rik protein
  • AA408215 protein
  • Hy5 protein
  • MEA5 protein
  • mKIAA0679 protein
  • Ncoat protein
  • O-GLCNACASE protein
  • OGA protein

Protein level used designations for MGEA5

O-GlcNAcase , bifunctional protein NCOAT , hyaluronidase in meningioma , meningioma-expressed antigen 5 , nuclear cytoplasmic O-GlcNAcase and acetyltransferase

GENE ID SPECIES
10724 Homo sapiens
76055 Mus musculus
154968 Rattus norvegicus
477802 Canis lupus familiaris
100152585 Sus scrofa
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