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Mesoderm Development Candidate 2 (MESDC2) ELISA Kits

Chaperone specifically assisting the folding of beta- propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Additionally we are shipping MESDC2 Antibodies (35) and MESDC2 Proteins (12) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
MESDC2 23184 Q14696
MESDC2 67943 Q9ERE7
MESDC2 308796 Q5U2R7
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Top MESDC2 ELISA Kits at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
Human
96 Tests Log in to see 11 to 13 Days
$875.60
Details
Mouse
96 Tests Log in to see 11 to 13 Days
$875.60
Details
Rat
96 Tests Log in to see 11 to 13 Days
$875.60
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Cow
96 Tests Log in to see 11 to 13 Days
$1,029.60
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Chicken
96 Tests Log in to see 11 to 13 Days
$1,095.60
Details

More ELISA Kits for MESDC2 Interaction Partners

Human Mesoderm Development Candidate 2 (MESDC2) interaction partners

  1. Mesd C-terminal region constitutes the major LRP5 (show LRP5 ELISA Kits)/6-binding domain, and that Mesd protein and its C-terminal region peptide have a potential therapeutic value in cancer

  2. Results indicate that Mesd is a universal inhibitor of Wnt (show WNT2 ELISA Kits)/LRP (show RPSA ELISA Kits) signaling on the cell surface.

  3. Results provide evidence that MESD functions as a general LRP (show RPSA ELISA Kits) chaperone and suggest that the Mesd phenotype results from both signaling and endocytic defects resulting from misfolding of multiple LRP (show RPSA ELISA Kits) receptors.

  4. Two structural and functional domains of MESD required for proper folding and trafficking of LRP5/LRP6 (show LRP5 ELISA Kits).

  5. a high bone mass mutant LRP5 (show LRP5 ELISA Kits)(G171V), has subtly reduced Dkk1 (show DKK1 ELISA Kits) binding, and, in contrast to LRP5 (show LRP5 ELISA Kits), no enhancement of binding with MesD

  6. as a result of (12;15)(q13;q25)translocation, the SUMO/Sentrin-specific protease 1 (show SENP1 ELISA Kits) gene (SENP1 (show SENP1 ELISA Kits)) on chromosome 12 and the embryonic polarity-related mesoderm development gene (MESDC2) on chromosome 15 are disrupted and fused

  7. Mesd and LRP6 (show LRP6 ELISA Kits) modulate Wnt (show WNT2 ELISA Kits) signaling.

Mouse (Murine) Mesoderm Development Candidate 2 (MESDC2) interaction partners

  1. Mescd2 binds to Lrp4 (show CORIN ELISA Kits) and regulates Lrp4 (show CORIN ELISA Kits) surface expression in myotubes.

  2. Mesd C-terminal region constitutes the major LRP5 (show LRP5 ELISA Kits)/6-binding domain, and that Mesd protein and its C-terminal region peptide have a potential therapeutic value in cancer

  3. The region 45-184 of MESD is essential and sufficient to act as a molecular chaperone (show HSP90AA1 ELISA Kits) for the low-density lipoprotein receptor (LDLR (show LDLR ELISA Kits)) family.

  4. We show that MESD contains a central folded domain flanked by unstructured regions required to facilitate maturation of LRP6 (show LRP6 ELISA Kits). Enforced expression of human MESD promotes the secretion of soluble minireceptors derived from LRP6 (show LRP6 ELISA Kits).

  5. Functional analyses of the Lrp6 (show LRP6 ELISA Kits) rs mutant showed decreased targeting to plasma membrane because of reduced interaction with Mesoderm development (Mesd), a chaperone for Lrp6 (show LRP6 ELISA Kits), leading to impaired Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling

  6. Secondary structure prediction using chemical shift data indicates that MESD(12-155) contains four a-helices and five b-sheets.

  7. Mesd not only blocks binding of Dickkopf (show DKK1 ELISA Kits) (DKK)-1 (show DKK1 ELISA Kits) and sclerostin (show SOST ELISA Kits) proteins to low-density lipoprotein receptor (show LDLR ELISA Kits)-related protein (LRP (show LRP1 ELISA Kits))5 (show LRP5 ELISA Kits) and LRP6 (show LRP6 ELISA Kits) but also inhibits Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling in LRP5 (show LRP5 ELISA Kits)- or LRP6 (show LRP6 ELISA Kits)- expressing cancer cells.

  8. Together our results show that in addition to serving as a folding chaperone, Mesd can function as a receptor antagonist by inhibiting ligand binding to mature LRP6 (show LRP6 ELISA Kits).

MESDC2 Antigen Profile

Antigen Summary

Chaperone specifically assisting the folding of beta- propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway, since some LDLRs are coreceptors for the canonical Wnt pathway (By similarity).

Gene names and symbols associated with MESDC2

  • mesoderm development candidate 2 (MESDC2) antibody
  • mesoderm development candidate 2 (mesdc2) antibody
  • mesoderm development candidate 2 (CpipJ_CPIJ010816) antibody
  • mesoderm development candidate 2 (Tsp_04045) antibody
  • Mesoderm development candidate 2 (LOC100157638) antibody
  • KIAA1199 (KIAA1199) antibody
  • mesoderm development candidate 2 (Mesdc2) antibody
  • 2210015O11Rik antibody
  • AW537813 antibody
  • BOCA antibody
  • mesd antibody
  • MESDC2 antibody
  • MGC115616 antibody
  • mKIAA0081 antibody
  • msd antibody
  • zgc:158636 antibody

Protein level used designations for MESDC2

mesoderm development candidate 2 , Mesoderm development candidate 2 , LDLR chaperone MESD , mesoderm development protein , renal carcinoma antigen NY-REN-61 , mesoderm development candiate 2

GENE ID SPECIES
453586 Pan troglodytes
488765 Canis lupus familiaris
712993 Macaca mulatta
734603 Xenopus laevis
6043369 Culex quinquefasciatus
10904464 Trichinella spiralis
100135217 Xenopus (Silurana) tropicalis
100157638 Sus scrofa
100174652 Pongo abelii
23184 Homo sapiens
67943 Mus musculus
308796 Rattus norvegicus
514610 Bos taurus
415475 Gallus gallus
791222 Danio rerio
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