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Transcription factor. Additionally we are shipping Mesoderm Posterior 1 Homolog (Mouse) Proteins (6) and many more products for this protein.
Showing 10 out of 63 products:
Human Polyclonal MESP1 Primary Antibody for WB - ABIN2781073
David, Brenner, Stieber, Schwarz, Brunner, Vollmer, Mentele, Müller-Höcker, Kitajima, Lickert, Rupp, Franz: MesP1 drives vertebrate cardiovascular differentiation through Dkk-1-mediated blockade of Wnt-signalling. in Nature cell biology 2008
Show all 3 references for ABIN2781073
Human Monoclonal MESP1 Primary Antibody for ELISA, WB - ABIN969284
Liu, Asakura, Inoue, Nakamura, Sano, Niu, Chen, Schwartz, Schneider: Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells. in Proceedings of the National Academy of Sciences of the United States of America 2007
MESP1, a pioneer cardiac factor, directs the appearance of mesendoderm, the intermediary of the earliest progenitors of mesoderm and endoderm organogenesis.
Studies indicate that mesodermal posterior 1 (Mesp1) and mesodermal posterior 2 (Mesp2 (show Mesp2 Antibodies)) double-knockout embryos exhibited defective development of the embryonic mesoderm.
Data indicate that transcription factor Mesp1 interacts physically with cAMP-responsive element binding protein 1 (Creb1 (show CREB1 Antibodies)) and transcriptionally regulates Ets variant 2 (Etv2 (show ETV2 Antibodies)) gene expression.
Embryonic heart development arises from distinct populations of unipotent and bipotent cardiac progenitors that independently express Mesp1 at different time points during their specification.
This Tcf (show HNF4A Antibodies)/Lef-Oct4 (show POU5F1 Antibodies) composite site mediated synergistic activation of the Mesp1 promoter by Oct4 (show POU5F1 Antibodies) and canonical Wnt (show WNT2 Antibodies) signaling.
Mesp1 is a context-dependent determination factor, integrating the stage of differentiation and the signaling environment to specify different lineage outcomes.
Overexpression of transcription factors MYOCD (show MYOCD Antibodies) and SRF alone or in conjunction with Mesp1 and SMARCD3 (show SMARCD3 Antibodies) enhanced the basal but necessary cardio-inducing effect of the previously reported GATA4 (show GATA4 Antibodies), TBX5 (show TBX5 Antibodies), and MEF2C (show MEF2C Antibodies).
These results place Eomes (show EOMES Antibodies) upstream of the Mesp1-dependent programme of cardiogenesis, and at the intersection of mesodermal and endodermal specification, depending on the levels of Activin (show Actbeta Antibodies)/Nodal signalling.
shRNA-based loss of Brachyury(T) causes a dramatic decrease in MesP1 expression accompanied by reduced cardiac markers in differentiating embryonic stem cells
Data show that Eomes (show EOMES Antibodies) promotes formation of cardiovascular progenitors by directly activating the bHLH transcription factor (show MSGN1 Antibodies) gene Mesp1 upstream of the core cardiac transcriptional machinery.
The MESP1-NKX2-5 (show NKX2-5 Antibodies) hESC reporter line allows us to identify molecular cues crucial for specification and expansion of human cardiac mesoderm and early progenitors and their differentiation to specific cardiovascular derivatives.
MESP1 SNPs are associated with congenital heart disease in patients and altered transcription in vitro.
Transcription factors ETS2 (show ETS2 Antibodies) and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors.
MesP1 drives vertebrate cardiovascular differentiation through Dkk-1 (show DKK1 Antibodies)-mediated blockade of Wnt (show WNT2 Antibodies)-signalling
Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways.
mesoderm posterior a
, mesoderm posterior 1
, mesoderm posterior 1 homolog (mouse)
, mesoderm posterior homolog B
, bHLH transcription factor mespa
, mesoderm posterior protein 1
, class C basic helix-loop-helix protein 5
, bHLH transcription factor
, mesoderm posterior 1 homolog
, mesoderm posterior 2 homolog