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Metal-Regulatory Transcription Factor 1 Proteins (MTF1)

MTF1 encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. Additionally we are shipping MTF1 Antibodies (35) and MTF1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MTF1 17764 Q07243
MTF1 4520 Q14872
Rat MTF1 MTF1 362591  
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Top MTF1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$246.96
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

MTF1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for Metal-Regulatory Transcription Factor 1 (MTF1) Interaction Partners

Zebrafish Metal-Regulatory Transcription Factor 1 (MTF1) interaction partners

  1. The functional characterization of a complete zebrafish MTF-1, is reported.

  2. MTF1 is a master regulator of gene expression during development.

Mouse (Murine) Metal-Regulatory Transcription Factor 1 (MTF1) interaction partners

  1. Findings identify a reciprocal activation mechanism involving HIF-2alpha (show EPAS1 Proteins) and the zinc-ZIP8 (show SLC39A8 Proteins)-MTF1 axis during osteoarthritis pathogenesis that amplifies catabolic signaling and cartilage destruction.

  2. MTF1 mediates the increase of CaV3.2 (show CACNA1H Proteins) mRNA and a rise in intracellular Zn(2+) which is associated with status epilepticus.

  3. the presence of SUMO moiety allows the MTF-1 protein to interact directly with metal-responsive element

  4. nuclear receptor SHP inhibits zinc-dependent induction of Dnmt1 (show DNMT1 Proteins) by antagonizing metal-responsive transcription factor-1.

  5. MTF-1 DNA-binding activity is strongly enhanced in the presence of zinc.

  6. PTEN associates with MTF-1 in cells in response to oxidative stress and in zinc homeostasis.

  7. Results reveal a novel repressive role for MTF-1 in the regulation of the Zip10 zinc transporter expression by pausing Pol II transcription.

  8. Data show that disruption of nucleosome structure at the MT-I (show MT1 Proteins) promoter is mediated by zinc-responsive recruitment of an active MTF-1-coactivator complex.

  9. Zinc and cadmium can activate FPN1 (show SLC40A1 Proteins) transcription through the MTF-1.

  10. mouse MTF-1 is polymorphic

Human Metal-Regulatory Transcription Factor 1 (MTF1) interaction partners

  1. MTF-1 (show MFI2 Proteins) has a role in regulating zinc dependent cellular processes at the molecular level [review]

  2. Forty-one single nucleotide polymorphisms (SNPs) within the MTF1 (show MFI2 Proteins) gene region.

  3. Human ZnT2 expression is regulated by MTF-1 (show MFI2 Proteins).

  4. Zn-responsive proteome profiling and time-dependent expression of proteins are regulated by MTF-1 (show MFI2 Proteins) in human alveolar epithelial cells.

  5. The zinc-sensing cytoplasmic transcription factor MTF-1 plays a key role in cellular zinc homoeostasis.

  6. Results identify a cysteine cluster that mediates homodimerization of human MTF-1 (show MFI2 Proteins), and show that dimer formation in vivo is important for basal and especially metal-induced transcriptional activity.

  7. Variations in the ability of LAT1 (show LAT Proteins)/DMT1 (show DMRT1 Proteins)/MTF1 (show MFI2 Proteins)/MT1a (show MT1A Proteins) to process and transport Hg may not play a significant role in the etiology of autism.

  8. It is concluded that SUMO conjugation and the SIM on MTF-1 do not play a critical role in suppressing transcriptional activity. Instead, MTF-1 forms complexes with cellular factors through SIM and SUMO moiety in the cytoplasm

  9. Transcriptional regulation of the beta-synuclein 5'-promoter metal response element by metal transcription factor-1.

  10. Zinc and cadmium can activate FPN1 (show SLC40A1 Proteins) transcription through the MTF-1 (show MFI2 Proteins).

MTF1 Protein Profile

Protein Summary

This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE).

Gene names and symbols associated with MTF1

  • metal-regulatory transcription factor 1 (MTF1)
  • metal-regulatory transcription factor 1 (mtf1)
  • metal-regulatory transcription factor 1 (LOC100218965)
  • metal-regulatory transcription factor 1 (LOC100352804)
  • metal response element binding transcription factor 1 (Mtf1)
  • metal-regulatory transcription factor 1 (Mtf1)
  • MGC86485 protein
  • MTF-1 protein
  • mtf1 protein
  • Thyls protein
  • ZRF protein

Protein level used designations for MTF1

metal regulatory transcription factor 1 , metal-regulatory transcription factor 1 , metal regulatory transcription factor 1-like , MRE-binding transcription factor , metalloregulatory transcription factor , transcription factor MTF-1 , MRE-binding transcription factor-1 , metal-responsive transcription factor 1 , zinc regulatory factor , metal response element binding transcription factor 1

GENE ID SPECIES
100054605 Equus caballus
195821 Danio rerio
428218 Gallus gallus
456766 Pan troglodytes
714795 Macaca mulatta
779158 Xenopus laevis
100218965 Taeniopygia guttata
100352804 Oryctolagus cuniculus
100457400 Pongo abelii
100480003 Ailuropoda melanoleuca
100495484 Xenopus (Silurana) tropicalis
100539531 Meleagris gallopavo
100555296 Anolis carolinensis
100620000 Monodelphis domestica
17764 Mus musculus
4520 Homo sapiens
608127 Canis lupus familiaris
509960 Bos taurus
362591 Rattus norvegicus
100511998 Sus scrofa
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