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MTF1 encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. Additionally we are shipping MTF1 Antibodies (39) and MTF1 Kits (3) and many more products for this protein.
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The functional characterization of a complete zebrafish MTF-1, is reported.
MTF1 is a master regulator of gene expression during development.
Findings identify a reciprocal activation mechanism involving HIF-2alpha (show EPAS1 Proteins) and the zinc-ZIP8 (show SLC39A8 Proteins)-MTF1 axis during osteoarthritis pathogenesis that amplifies catabolic signaling and cartilage destruction.
MTF1 mediates the increase of CaV3.2 (show CACNA1H Proteins) mRNA and a rise in intracellular Zn(2+) which is associated with status epilepticus.
the presence of SUMO moiety allows the MTF-1 protein to interact directly with metal-responsive element
nuclear receptor SHP inhibits zinc-dependent induction of Dnmt1 (show DNMT1 Proteins) by antagonizing metal-responsive transcription factor-1.
MTF-1 DNA-binding activity is strongly enhanced in the presence of zinc.
PTEN associates with MTF-1 in cells in response to oxidative stress and in zinc homeostasis.
Results reveal a novel repressive role for MTF-1 in the regulation of the Zip10 zinc transporter expression by pausing Pol II transcription.
Data show that disruption of nucleosome structure at the MT-I (show MT1 Proteins) promoter is mediated by zinc-responsive recruitment of an active MTF-1-coactivator complex.
Zinc and cadmium can activate FPN1 (show SLC40A1 Proteins) transcription through the MTF-1.
mouse MTF-1 is polymorphic
MTF1 heads a hierarchy of zinc sensors, and through controlling the expression of a raft of metallothioneins and other key proteins involved in controlling intracellular zinc levels (e.g. ZnT1) alters zinc buffering capacity and total cellular zinc content.
MTF-1 (show MFI2 Proteins) has a role in regulating zinc dependent cellular processes at the molecular level [review]
Forty-one single nucleotide polymorphisms (SNPs) within the MTF1 (show MFI2 Proteins) gene region.
Human ZnT2 expression is regulated by MTF-1 (show MFI2 Proteins).
Zn-responsive proteome profiling and time-dependent expression of proteins are regulated by MTF-1 (show MFI2 Proteins) in human alveolar epithelial cells.
The zinc-sensing cytoplasmic transcription factor MTF-1 plays a key role in cellular zinc homoeostasis.
Results identify a cysteine cluster that mediates homodimerization of human MTF-1 (show MFI2 Proteins), and show that dimer formation in vivo is important for basal and especially metal-induced transcriptional activity.
Variations in the ability of LAT1 (show LAT Proteins)/DMT1 (show DMRT1 Proteins)/MTF1 (show MFI2 Proteins)/MT1a (show MT1A Proteins) to process and transport Hg may not play a significant role in the etiology of autism.
It is concluded that SUMO conjugation and the SIM on MTF-1 do not play a critical role in suppressing transcriptional activity. Instead, MTF-1 forms complexes with cellular factors through SIM and SUMO moiety in the cytoplasm
Transcriptional regulation of the beta-synuclein 5'-promoter metal response element by metal transcription factor-1.
This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE).
metal regulatory transcription factor 1
, metal-regulatory transcription factor 1
, metal regulatory transcription factor 1-like
, MRE-binding transcription factor
, metalloregulatory transcription factor
, transcription factor MTF-1
, MRE-binding transcription factor-1
, metal-responsive transcription factor 1
, zinc regulatory factor
, metal response element binding transcription factor 1