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MITF encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. Additionally we are shipping MITF Antibodies (173) and MITF Proteins (5) and many more products for this protein.
Showing 4 out of 13 products:
Human MITF ELISA Kit for Sandwich ELISA - ABIN423263
Otreba, Wrze?niok, Beberok, Rok, Buszman: Melanogenesis and antioxidant defense system in normal human melanocytes cultured in the presence of chlorpromazine. in Toxicology in vitro : an international journal published in association with BIBRA 2015
Show all 2 references for ABIN423263
Rat (Rattus) MITF ELISA Kit for Sandwich ELISA - ABIN579092
Shirpoor, Salami, Khadem-Ansari, Heshmatian, Ilkhanizadeh: Long-term ethanol consumption initiates atherosclerosis in rat aorta through inflammatory stress and endothelial dysfunction. in Vascular pharmacology 2012
Accumulating mutations in series of haplotypes at the KIT and MITF loci are major determinants of white markings in Franches-Montagnes horses.
several independent mutations in MITF and PAX3 (show PAX3 ELISA Kits) together with known variants in the EDNRB (show EDNRB ELISA Kits) and KIT genes explain a large proportion of horses with the more extreme white spotting phenotypes.
DRD4 (show DRD4 ELISA Kits) antagonist has an antimelanogenic effect that is related to downregulation of MITF transcription through the activation of the ERK (show EPHB2 ELISA Kits)
Akt (show AKT1 ELISA Kits) modulates nuclear translocation of MITF.
Our studies have established that the cooperative antiproliferative effects of aspirin and I3C in human melanoma cells trigger a significant downregulation of MITF-M gene expression and disruption of MITF-M promoter activity. results demonstrate that aspirin-regulated Wnt (show WNT2 ELISA Kits) signaling and I3C-targeted signaling pathways converge at distinct DNA elements in the MITF-M promoter to cooperatively disrupt MITF-M expression
Addition of MITF>/=50% into the logistic regression analysis significantly improves the accuracy of the melanoma nomogram in prediction of regional nodal spread
The MITF p.E318K mutation does not appear to play a major role in sporadic renal cell carcinoma carcinogenesis, but is possibly restricted to a rare subpopulation of inherited renal cell carcinoma
Immunohistochemistry using D2-40 monoclonal antibody (MAGE2) and anti-MITF1 increased detection of lymphovascular invasion in primary cutaneous melanoma.
Overexpression of MITF is associated with melanoma cell survival and progression.
We conclude that the expression of Rlbp1 and Rdh5 critically depends on functional Mitf in the RPE and suggest that MITF has an important role in controlling retinoid processing in the RPE.
A concomitant AURKA (show AURKA ELISA Kits)/BRAF (show BRAF ELISA Kits) and AURKA (show AURKA ELISA Kits)/MEK (show MAP2K1 ELISA Kits) targeting overcame MAPK (show MAPK1 ELISA Kits) signaling activation-associated resistance signature in BRAF (show BRAF ELISA Kits)- and NRAS (show NRAS ELISA Kits)-mutated melanomas, respectively, and elicited heightened anti-proliferative activity and apoptotic cell death.
Results show that Mitf, probably including Mitf-M, is expressed in the mitral cells and tufted cells that transmit the information derived from olfactory sensory neurons to the olfactory cortex.
protein expression level of MITF and p-CREB signaling pathway are significantly increased. Moreover, 60Hz ELF-EMFs reduce the phosphorylate of ERK in B16F10 melanoma cel
Microphthalmia-associated transcription factor regulates skin melanoblast migration by repressing the melanoma cell adhesion molecule (show MCAM ELISA Kits)
These findings demonstrate that LC3 (show MAP1LC3A ELISA Kits) contributes to melanogenesis by increasing ERK (show EPHB2 ELISA Kits)-dependent MITF expression, thereby providing a mechanistic insight into the signaling network that links autophagy to melanogenesis.
the retinal degeneration associated with the disruption of the visual cycle in Mitf-deficient mice can be partially corrected both structurally and functionally by an exogenous supply of 9-cis-retina
Therefore, it is reasonable to assume that the increase in the expression of Mitf in melanocytes is involved in the age-ssociated increase in the pigmentation in the eyes of black-eyed mice.
MITF interacts with BRG1 (show SMARCA4 ELISA Kits) to promote GATA4 (show GATA4 ELISA Kits) expression in cardiac hypertrophy.
Overexpression of FHL2 (show FHL2 ELISA Kits) alone had no effect on Erbin (show ERBB2IP ELISA Kits) expression, but in the presence of MITF, Erbin (show ERBB2IP ELISA Kits) expression was decreased.
A reciprocal antagonism between the MITF and c-Jun (show JUN ELISA Kits) interconnects inflammation-induced dedifferentiation with pro-inflammatory cytokine responsiveness of melanoma cells favouring myeloid cell recruitment.
BPTF likely acts as a cofactor for other transcription factors in MITF-negative melanoma cells and there are clearly genes regulated by BPTF, but not MITF, in MITF-expressing lines.
Variability in the MITF gene clearly explained the differences between spotted and non-spotted cattle phenotypes but, at the same time, it is evident that this gene is not the only genetic factor determining piebaldism in two of the studied cattle breeds.
The objectives of this study were to characterize the phenotypes of German White Fleckvieh and to identify the mutation responsible for this newly detected phenotype in cattle using genome-wide association analyses and re-sequencing of MITF.
Although MITF does not seem to be the causal gene of the QTL initially observed, it can not be excluded that a prominent role of its transcription and function in the outbreak and evolution of the tumors observed in pigs.
This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
microphthalmia transcription factor
, microphthalmia-associated transcription factor
, micophthalmia-associated transcription factor b
, class E basic helix-loop-helix protein 32
, black eyed white
, transcription factor
, microphtalmia-associated transcription factor