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MITF encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. Additionally we are shipping MITF Antibodies (130) and MITF Proteins (5) and many more products for this protein.
Showing 4 out of 11 products:
Human MITF ELISA Kit for Sandwich ELISA - ABIN423263
Otreba, Wrze?niok, Beberok, Rok, Buszman: Melanogenesis and antioxidant defense system in normal human melanocytes cultured in the presence of chlorpromazine. in Toxicology in vitro : an international journal published in association with BIBRA 2015
Show all 2 references for ABIN423263
Rat (Rattus) MITF ELISA Kit for Sandwich ELISA - ABIN579092
Shirpoor, Salami, Khadem-Ansari, Heshmatian, Ilkhanizadeh: Long-term ethanol consumption initiates atherosclerosis in rat aorta through inflammatory stress and endothelial dysfunction. in Vascular pharmacology 2012
Accumulating mutations in series of haplotypes at the KIT and MITF loci are major determinants of white markings in Franches-Montagnes horses.
several independent mutations in MITF and PAX3 (show PAX3 ELISA Kits) together with known variants in the EDNRB (show EDNRB ELISA Kits) and KIT genes explain a large proportion of horses with the more extreme white spotting phenotypes.
In addition to melanoma risk, MITF p.E318K is associated with a high nevi count and could play a role in fast-growing melanomas.
expression of the molecular marker Mitf in primary cutaneous melanomas is a useful tool in assessing lymph node status.
an MITF-CEACAM1 (show CEACAM1 ELISA Kits) axis is suggested as a potential determinant of melanoma progression.
LEF-1 (show LEF1 ELISA Kits) and MITF regulate tyrosinase (show TYR ELISA Kits) gene transcription in vitro via binding to its promoter.
Here we show that MITF-A mRNA is predominantly expressed in all three human liver cancer cell lines examined.
Data show that mutant microphthalmia-associated transcription factor (MITF) with loss of localization signals (NLS (show ALDH1A2 ELISA Kits)) has failed to transactivate the transcriptional activities of target gene tyrosinase (TYR (show TYR ELISA Kits)), which can cause Waardenburg syndrome.
Data suggest that the heterozygous deletion mutation c.649_651delAGA in exon 7 of the microphthalmia-associated transcription factor (MITF) gene probably underlies the disease in the first family.
A reciprocal antagonism between the MITF and c-Jun (show JUN ELISA Kits) interconnects inflammation-induced dedifferentiation with pro-inflammatory cytokine responsiveness of melanoma cells favouring myeloid cell recruitment.
MITF expression may affect the melanoma phenotype with consequences on the survival, invasion and metastasis of melanoma cells, and we discuss the research challenges. Review.
direct contact of melanoma cells with the remote epidermal layer triggers vertical invasion via Notch (show NOTCH1 ELISA Kits) signaling activation, the latter serving to inhibit MITF function.
Therefore, it is reasonable to assume that the increase in the expression of Mitf in melanocytes is involved in the age-ssociated increase in the pigmentation in the eyes of black-eyed mice.
MITF interacts with BRG1 (show SMARCA4 ELISA Kits) to promote GATA4 (show GATA4 ELISA Kits) expression in cardiac hypertrophy.
Overexpression of FHL2 (show FHL2 ELISA Kits) alone had no effect on Erbin (show ERBB2IP ELISA Kits) expression, but in the presence of MITF, Erbin (show ERBB2IP ELISA Kits) expression was decreased.
BPTF likely acts as a cofactor for other transcription factors in MITF-negative melanoma cells and there are clearly genes regulated by BPTF, but not MITF, in MITF-expressing lines.
the crucial role of signaling dependent MITF/p38 MAPK (show MAPK14 ELISA Kits) interactions in osteoclast differentiation
HDAC7 (show HDAC7 ELISA Kits) in osteoclasts is an important molecular regulator of MITF activity and bone homeostasis.
MITF-BRG1 (show SMARCA4 ELISA Kits) interplay thus plays an essential role in transcription regulation in melanoma.
Expression of microRNA-211 is regulated by the key melanocyte transcription factor MITF and regulates pigmentation by targeting the TGF-beta (show TGFB1 ELISA Kits) receptor 2.
Low MITF/AXL (show AXL ELISA Kits) ratio predicts early resistance to multiple targeted drugs in melanoma.
Variability in the MITF gene clearly explained the differences between spotted and non-spotted cattle phenotypes but, at the same time, it is evident that this gene is not the only genetic factor determining piebaldism in two of the studied cattle breeds.
The objectives of this study were to characterize the phenotypes of German White Fleckvieh and to identify the mutation responsible for this newly detected phenotype in cattle using genome-wide association analyses and re-sequencing of MITF.
Although MITF does not seem to be the causal gene of the QTL initially observed, it can not be excluded that a prominent role of its transcription and function in the outbreak and evolution of the tumors observed in pigs.
This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
microphthalmia transcription factor
, microphthalmia-associated transcription factor
, micophthalmia-associated transcription factor b
, class E basic helix-loop-helix protein 32
, black eyed white
, transcription factor
, microphtalmia-associated transcription factor