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involved in the O-acetylation of GD3 ganglioside sialic acid [RGD, Feb 2006].. Additionally we are shipping MFGE8 Kits (41) and MFGE8 Proteins (30) and many more products for this protein.
Showing 10 out of 165 products:
Human Monoclonal MFGE8 Primary Antibody for CyTOF, FACS - ABIN4899815
Jinushi, Nakazaki, Carrasco, Draganov, Souders, Johnson, Mihm, Dranoff: Milk fat globule EGF-8 promotes melanoma progression through coordinated Akt and twist signaling in the tumor microenvironment. in Cancer research 2008
MFG-E8 could be a potential novel prognostic marker for colorectal cancer (CRC (show CALR Antibodies)) and overexpression of MFG-E8 might be involved in lymph node metastasis and angiogenesis of CRC (show CALR Antibodies).
MFG-E8 levels are elevated in T2D but suppressed by increased adipose tissues, thereby allowing inflammatory factors to rise to high levels. MFG-E8 may serve as a potential biomarker for obesity and T2D in the clinical setting
These findings provide a better understanding of the molecular mechanism underlying colorectal cancer progression and suggest a predictive role for MFG-E8 in colorectal cancer metastasis and prognosis
Levels of MFGE8 were reduced in cirrhotic liver tissue from patients compared with controls.
an efficient purification method for production of non-aggregated, full-length MFG-E8.
Reduced serum milk fat globule-epidermal growth factor (show EGF Antibodies) 8 (MFG-E8) concentrations are associated with an increased risk of microvascular complications in patients with type 2 diabetes.
MFG-E8 is a protective factor in the pathogenesis of rheumatoid arthritis and subsequent bone loss.
After myocardial infarction, Mfge8 (and Mertk (show MERTK Antibodies))-expressing macrophages synergistically engage the clearance of injured cardiomyocytes.
MFG-E8 promotes cutaneous wound healing by enhancing angiogenesis.
Lactadherin may decrease inflammation by inhibiting secretory phospholipase A2 (show YWHAZ Antibodies) activity on pre-apoptotic leukemia cells.
The vesicular environment provides optimal conditions for presentation and recognition of phosphatidylserine by lactadherin in a simple binding mechanism.
lactophorin C-terminal fragment (LP16) and bovine milk fat globule membrane protein PAS6/7 strongly inhibited the replication of human rotavirus replication
Lactadherin inhibits enzyme complexes of blood coagulation by competing for phospholipid-binding sites.
The number of lactadherin binding sites increased proportionally to the phosphatidylserine content over a range 0-2% and less rapidly for higher phosphatidylserine content
The crystal structure of the bovine lactadherin C2 domain (residues 1 to 158) at 2.4 A, was determined.
angiogenic endothelial cells have phagocytic properties for lactadherin-opsonized large particles and apoptotic cells
MFG-E8 administration was associated with decreased inflammasome activation in the kidney. Adoptive transfer of MFG-E8-stimulated macrophages reduced activation of inflammasome and tissue damage. The protective role of MFG-E8 in ureteral obstruction kidney injury is mediated through anti-inflammatory macrophage reprogramming which results in decreased inflammasome activation, preventing severe tissue damage.
characterization of the mechanisms by which macrophage derived MFG-E8 regulates wound inflammation; wound macrophage-derived MFG-E8 was recognized as a critical driver of wound angiogenesis
MFG-E8 acts at two levels, by increasing VEGF (show VEGFA Antibodies) and ET-1 (show EDN1 Antibodies) expression in mesenchymal stromal cells (MSC (show MSC Antibodies)) and by enhancing M2 polarization of macrophages, to increase tumor angiogenesis.
MFGE8 is an anti-fibrotic protein in mesenchymal stem cell secretomes that strongly inhibits TGFbeta (show TGFB1 Antibodies) signaling and reduces extracellular matrix deposition and liver fibrosis in mice.
Milk fat globule-epidermal growth factor (show EGF Antibodies)-factor VIII downregulates interleukin-17 (show IL17A Antibodies) expression in sepsis by modulating STAT3 (show STAT3 Antibodies) activation.
Data indicate that Sp1 (show SP1 Antibodies) and AP-1 (show JUN Antibodies)-related factors are involved in the regulation of MFG-E8 gene transcription by targeting their binding sites in the 5'-flanking region under physiological and inflammatory states.
MFG-E8 promotes tumor growth regardless of the presence or absence of colonic inflammation, whereas colon tumor development is initiated by MFG-E8 under inflammatory conditions.
The MFG-E8 in breast milk may mask the phosphatidylserine exposed on the surface of mik fat globules(MFGs) with time after secretion and thereby suppress the membrane fusion among MFGs resulting in the enlargement of MFGs in the breast milk.
The evidence suggests that lactadherin and the other F4-binding milk proteins, together with other defense components of milk, could play a role in protection of neonatal piglets against ETEC induced diarrhea.
involved in the O-acetylation of GD3 ganglioside sialic acid
milk fat globule-EGF factor 8 protein
, sperm-membrane associated protein P47
, O-acetyl disialoganglioside synthase
, breast epithelial antigen BA46
, sperm associated antigen 10
, sperm surface protein hP47
, PAS-6/PAS-7 glycoprotein
, components 15/16
, sperm surface protein SP47
, EGF/factor VIII
, milk fat globule glycoprotein
, O-acetyl GD3 ganglioside synthase
, O-acetyltransferase Milk fat glolbule membrane protein
, O-acetyltransferase milk fat globule membrane protein
, milk fat globule EGF factor 8 protein
, pP47 protein