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The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. Additionally we are shipping Minichromosome Maintenance Complex Component 3 Associated Protein Proteins (5) and Minichromosome Maintenance Complex Component 3 Associated Protein Kits (3) and many more products for this protein.
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Human Polyclonal MCM3AP Primary Antibody for ICC, IF - ABIN4333203
Singh, Maeda, Eid, Almofty, Ono, Pham, Goodman, Sakaguchi: GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy. in Nature communications 2013
These results indicated that the GANP protein is associated with breast cancer resistance.
GANP is induced in activated T4 cells & physically interacts with A3G. GANP is encapsidated in HIV-1 virions & modulates A3G packaging into the cores. Upregulation increases A3G-catalyzed viral G-->A hypermutation, suppressing infectivity.
A homozygous potentially pathogenic variant (c.2743G>A) was identified, which encodes amino acid Lys (show LYZ Antibodies), instead of conserved Glu (show DCTN1 Antibodies), at the position 915, in patients with mild intellectual disability.
GANP-mediated chromatin modification promotes transcription complex recruitment and positioning at immunoglobulin variable loci to favour AID targeting.
The cellular protein MCM3AP is required for inhibition of cellular DNA synthesis by the IE86 protein of human cytomegalovirus.
HBV DNA integration sites into human genome were random, and MCM3AP was a new site.
GANP, a homologue of yeast Sac3 that is involved in mRNA export, is indispensable for ensuring the stability of human genomic DNA and GANP knockdown causes apoptosis and necrosis of p53 (show TP53 Antibodies)-insufficient cancer cells.
GANP transgene may play a critical role in Lyn tyrosine-protein kinase-mediated signaling during selection of high-affinity B cells in peripheral lymphoid organs.
MCM3AP and GANP are different proteins, occupying different locations in the cell and transcribed from different promoters
Data show that human germinal center-associated nuclear protein (GANP) is critically involved in cell proliferation at the mitotic phase through its selective support of shugoshin-1 (show SGOL1 Antibodies) mRNA export.
GANP plays a positive role in IgV region diversification of DT40 B cells in a nonhomologous end joining-proficient state. DNA-PKcs (show PRKDC Antibodies) physically interacts with GANP, and this interaction is dissociated by dsDNA breaks
GANP may serve as an essential link required to transport AID to B (show TDO2 Antibodies)-cell nuclei and to target AID to actively transcribed IgV regions
interaction with MCM3 (show MCM3 Antibodies) is associated with a novel phosphatase component G5PR (show PPP2R3C Antibodies)
GANP(hi)plasma-like cells appear in lymph nodes of autoimmune mice during aging
Decreased expression of germinal center-associated protein (GANP) in Lyn (show LYN Antibodies) kinase-deficient mice suggests that Lyn (show LYN Antibodies) controls the formation and proliferation of germinal centers via GANP.
GANP is involved in V region alteration generating high-affinity Ab.
GANP has a critical role in suppression of DNA hyper-recombination in mammalian cells
The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization.
80 kDa MCM3-associated protein
, minichromosome maintenance deficient 3 associated protein
, minichromosome maintenance complex component 3 associated protein
, minichromosome maintenance protein 3 associated protein
, MCM3 minichromosome maintenance deficient 3 associated protein
, 80 kDa MCM3-associated protein-like
, MCM3 import protein
, germinal center-associated nuclear protein
, germinal-centre associated nuclear protein
, minichromosome maintenance deficient 3-associated protein
, nuclear protein GANP