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Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Additionally we are shipping Mitochondrially Encoded NADH Dehydrogenase 1 Antibodies (36) and Mitochondrially Encoded NADH Dehydrogenase 1 Proteins (7) and many more products for this protein.
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This review focuses on the role of mitochondrial genes in causing LHON and therapeutics available for treating the disease. A systematic search has been adopted in various databases using the keywords "LHON," "mitochondria," "ND1," "ND4 (show MT-ND4 ELISA Kits)," "ND6 (show MT-ND6 ELISA Kits)," and "therapy" and the following review on mitochondrial genetics.
The MT-ND1 m.3635G>A mutation has resulted in decreased efficiency of ATP synthesis.
the MT-ND1 gene is a hot spot for mutations associated with LHON.
ND1 genetic polymorphisms associated with breast cancer in Mizoram mongloid population.
The present study revealed no association between MS and T4216C variation in the ND1 mtDNA gene in the Iranian population.
ND1 T3866C mutation is associated with Chinese families with Leber's hereditary optic neuropathy.
To investigate the pathophysiology of Leber's hereditary optic neuropathy (LHON), a cohort of 1164 Han Chinese subjects with LHON were screened for ND1 G3460A mutation.
m.3460G>A/MT-ND1 mutation caused only a reduction in mitochondrial complex I(CI) activity, whereas the m.3571insC/MT-ND1 and the m.3243A>G/MT-TL1 (show TNFSF15 ELISA Kits) mutations induced a severe structural and functional CI alteration.
Novel mutations m.3959G>A and m.3995A>G in mitochondrial gene MT-ND1 associated with MELAS.
In Sherpa people, 2 mutations are ND1 mutants. One of them was reported as the primary mutation for Leber's hereditary optic neuropathy suggesting a certain effect on Complex I function and might be important in the altitude adaptation for Sherpa people.
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
NADH dehydrogenase subunit 1
, NADH-ubiquinone oxidoreductase chain 1
, PPIase A
, cyclophilin A
, cyclosporin A-binding protein
, peptidyl-prolyl cis-trans isomerase A
, rotamase A