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Mitochondrially Encoded NADH Dehydrogenase 4 Proteins (MT-ND4)

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Additionally we are shipping Mitochondrially Encoded NADH Dehydrogenase 4 Kits (7) and Mitochondrially Encoded NADH Dehydrogenase 4 Antibodies (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MT-ND4 4538 P03905
MT-ND4 17719 P03911
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Top Mitochondrially Encoded NADH Dehydrogenase 4 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

MT-ND4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Mitochondrially Encoded NADH Dehydrogenase 4 (MT-ND4) Interaction Partners

Human Mitochondrially Encoded NADH Dehydrogenase 4 (MT-ND4) interaction partners

  1. the ND4 gene is the hot spot for mutations associated with Leber's hereditary optic neuropathy

  2. Three mutations were significantly related to the presence of epilepsy. These mutations were found at the 8502, 11994, and 13,231 bp of mtDNA, which resulted in amino acid changes at the MT-ATP-8 (show MT-ATP8 Proteins), MT-ND4 and MT-ND5 (show MT-ND5 Proteins) genes.

  3. Expression of WT human ND4 in cells with the G11778A mutation in ND4 led to restoration of defective ATP synthesis.

  4. altered activity of complex III modulates the phenotypic manifestation of Leber's hereditary optic neuropathy-associated ND4 G11778A mutation

  5. Patients with somatically acquired ND4 mutations had significantly longer relapse-free survival (P=0.017) and overall survival (OS) (P=0.021) than ND4(wildtype) patients

  6. Molecular analysis of mitochondrial genome identified the known ND4 G11778A mutation and 51 variants, belonging to Asian haplogroup C4a1.

  7. Twenty-five subjects with Leber hereditary optic neuropathy (LHON) and 21 carriers positive for the G11778A mitochondrial DNA mutation were recruited. Three additional mutations in the ND4 gene, G11719A, G11947A, or G11914A, were detected.

  8. Treatment of acute visual loss due to LHON may be possible with a normal human ND4 subunit gene of complex I, mutated in most cases of LHON, when delivered by an scAAV vector.

  9. The mutations G3460A and G11778A in the mitochondrial genes MTND1 (show MT-ND1 Proteins) and MTND4, known to be causative for LHON.

  10. A novel missense mutation (C11994T) in the ND4 gene, which replaces threonine with isoleucine, was observed in all of the oligoasthenozoospermic men but not in any of the normozoospermic fertile men.

Mouse (Murine) Mitochondrially Encoded NADH Dehydrogenase 4 (MT-ND4) interaction partners

  1. Cybrid mice showed normal respiratory function whether or not their mtDNA possessed the A11181G mutation of the mt-Nd4 gene, suggesting that the this mutation is not responsible for respiration defects found in SAMP8 mice.

Arabidopsis thaliana Mitochondrially Encoded NADH Dehydrogenase 4 (MT-ND4) interaction partners

  1. The data supports a model for MTSF1 functioning in which its association with the last nucleotides of the nad4 3' untranslated region stabilizes nad4 mRNA.

Mitochondrially Encoded NADH Dehydrogenase 4 (MT-ND4) Protein Profile

Protein Summary

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).

Gene names and symbols associated with MT-ND4

  • mitochondrially encoded NADH dehydrogenase 4 (MT-ND4)
  • NADH dehydrogenase 4, mitochondrial (mt-Nd4)
  • NADH dehydrogenase subunit 4 (ND4)
  • NADH dehydrogenase subunit 4 (nad4)
  • NADH dehydrogenase subunit 4 (NAD4)
  • NADH dehydrogenase, subunit 4 (nad4)
  • MTND4 protein
  • NADH4 protein

Protein level used designations for MT-ND4

NADH dehydrogenase subunit 4

GENE ID SPECIES
4538 Homo sapiens
17719 Mus musculus
3283886 Bos taurus
804483 Canis lupus familiaris
807643 Gallus gallus
808510 Sus scrofa
808225 Oryctolagus cuniculus
2565705 Caenorhabditis elegans
814596 Arabidopsis thaliana
807666 Ascaris suum
807960 Locusta migratoria
802562 Candida albicans SC5314
808213 Branchiostoma lanceolatum
1734028 Acanthamoeba castellanii
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