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activity\; localization, and function is regulated by the C-terminal tail [RGD, Feb 2006].. Additionally we are shipping Mitogen-Activated Protein Kinase 15 Antibodies (86) and Mitogen-Activated Protein Kinase 15 Kits (12) and many more products for this protein.
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CapZIP (show RCSD1 Proteins), which has been shown to regulate ciliogenesis, is an ERK7 substrate, and that Dishevelled (show DVL2 Proteins), which has also been shown to regulate ciliogenesis, facilitates ERK7 phosphorylation of CapZIP (show RCSD1 Proteins) through binding to both ERK7 and CapZIP (show RCSD1 Proteins).
In HeLa cells, phosphorylation of HuR (show ELAVL1 Proteins) by ERK8 prevents it from binding to PDCD4 (show PDCD4 Proteins) mRNA and allows miR (show MLXIP Proteins)-21-mediated degradation of PDCD4 (show PDCD4 Proteins).
depletion of endogenous MAPK15 expression inhibited BCR (show BCR Proteins)-ABL1 (show ABL1 Proteins)-dependent cell proliferation, in vitro
The present study suggests that MAPK15 overexpression may contribute to the malignant transformation of gastric mucosa by prolonging the stability of c-Jun (show JUN Proteins).
ERK8 appears as a constitutive brake on N-Acetylgalactosaminyltransferase (show B4GALNT2 Proteins) relocalisation, and the loss of its expression could drive cancer aggressivity through increased cell motility.
Data suggest that the model coulb be a tool for the development of specific ERK8 kinase inhibitors.
ATG8 (show GABARAPL2 Proteins)-like proteins (MAP1LC3B (show MAP1LC3B Proteins), GABARAP (show GABARAP Proteins) and GABARAPL1 (show GABARAPL1 Proteins)) are novel interactors of MAPK15/ERK8, a MAP kinase (show MAPK1 Proteins) involved in cell proliferation and transformation.
a novel function for ERK8 as a bona fide ERRalpha (show ESRRA Proteins) corepressor, involved in control of its cellular localization by nuclear exclusion, and suggest a key role for this MAP kinase (show MAPK1 Proteins) in the regulation of the biological activities of this nuclear receptor.
Data show that ERK8 prevents HDM2-mediated PCNA (show PCNA Proteins) destruction by inhibiting the association of PCNA (show PCNA Proteins) with HDM2, and implicate ERK8 in the regulation of genomic stability.
Extracellular signal-regulated kinase 8-mediated c-Jun (show JUN Proteins) phosphorylation increases tumorigenesis of human colon cancer
ERK8, a new member of the mitogen-activated protein kinase (show MAPK1 Proteins) family.
Taken together, our results suggest that ERK8 plays an important role in spindle organization during mouse oocyte meiotic maturation and early embryo cleavage.
Erk8 has a role as a novel effector of RET (show RET Proteins)/PTC3 (show NCOA4 Proteins) and, therefore, RET (show RET Proteins) biological functions
activity\; localization, and function is regulated by the C-terminal tail
mitogen-activated protein kinase 15
, extracellular signal-regulated kinase 7
, MAP kinase 15
, MAPK 15
, extracellular regulated kinase 8 delta
, extracellular signal regulated kinase 8
, extracellular signal-regulated kinase 8