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MUC5B encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. Additionally we are shipping MUC5B Antibodies (83) and MUC5B Kits (36) and many more products for this protein.
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Both compounds down regulated mucin (show SLC13A2 Proteins) 5 subtype B, and peptidoglycan recognition protein 1 (show PGLYRP1 Proteins) in vaginal tissue
Expressions of Orai1 (show TMEM132A Proteins), Muc5b, IL-4 (show IL4 Proteins), IL-5 (show IL5 Proteins), IL-13 (show IL13 Proteins) and IL-33 (show IL33 Proteins) were up-regulated in the allergic state and IL-33 (show IL33 Proteins) increased the levels of Muc5b, IL-4 (show IL4 Proteins), IL-5 (show IL5 Proteins) and IL-13 (show IL13 Proteins), but did not influence proliferation of T cells.
deleting either the Muc5ac or Muc5b gene is insufficient to create an observable dry eye phenotype on the ocular surface of these mice.
mouse Muc5b (but not Muc5ac) is required for mucociliary clearance, for controlling infections in the airways and middle ear, and for maintaining immune homeostasis in mouse lungs, whereas Muc5ac is dispensable
Muc5b was detected in all mammary tumors analyzed from MMTV-ras mice
Muc5b is a target gene of transcription factors (TTF-1, GATA-6) involved in lung differentiation programs during development and carcinogenesis. TTF-1 is a strong repressor of Muc5b.
analysis of Muc5ac and Muc5b production during prenatal and postnatal murine lung development
Acidic pH drives middle ear epithelial Muc5b gene expression in vitro, which perhaps explains how laryngopharyngeal reflux can contribute to otitis media.
The isolation and characterization of the mouse Muc5b mucin (show SLC13A2 Proteins) gene (mMuc5b), determined its complete cDNA sequence, its genomic organization, and chromosomal localization and expression.
C-mannosylation is likely required for proper folding of the Cys (show DNAJC5 Proteins) subdomains and/or for some aspect of ER export during mucin (show SLC13A2 Proteins) biosynthesis
The MUC5B promoter polymorphism is the strongest and the most replicated genetic risk factor for Idiopathic pulmonary fibrosis. It is involved in disease pathogenesis through an increase in MUC5B expression in terminal bronchi and honeycombed cysts.
We propose a mechanism whereby MUC5B decreases surface tension lowering capacity of alveolar surfactant at areas with maximal mechanical stress
These results suggest that MUC5B production can be regulated by ECM (show MMRN1 Proteins) components and that MUC5B is upregulated by fibronectin (show FN1 Proteins) and laminin via the integrin, ERK (show EPHB2 Proteins), and NF-kappaB (show NFKB1 Proteins) dependent pathway.
MUC5B promoter genotype was not associated with high attenuation areas on lung computed tomography.
Overexpression of MUC5B has been described in idiopathic pulmonary fibrosis lungs. Read More: http://www.atsjournals.org/doi/full/10.1164/rccm.201507-1322LE#.V2WAGNLrtNs
The variant allele of a common MUC5B promoter variant, rs35705950, is significantly associated with both familial and sporadic idiopathic pulmonary fibrosis. Read More: http://www.atsjournals.org/doi/full/10.1164/rccm.201509-1872LE#.V2WBpNLrtNs
Mucin 5B promoter polymorphism is associated with the risk for interstitial lung diseases mainly in older male Chinese subjects
MUC5B is a novel prognostic biomarker for patients with non-small cell lung cancer (NSCLC)carrying EGFR (show EGFR Proteins) mutations but not for patients with NSCLC carrying wild-type EGFR (show EGFR Proteins)
MUC5B has recently been shown to be associated with idiopathic pulmonary fibrosis susceptibility and survival. Read More: http://www.atsjournals.org/doi/full/10.1164/rccm.201505-1010OC#.VwqiYdLrvyA
strong association between the MUC5B promoter rs35705950 minor T allele and idiopathic pulmonary fibrosis susceptibility particularly evident in the Caucasian population, milder but still significant in the Asian population [meta-analysis]
This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases.
cervical mucin MUC5B
, high molecular weight salivary mucin MG1
, mucin 5, subtype B, tracheobronchial
, sublingual gland mucin
, ovomucin, alpha-subunit