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The protein encoded by MVB12B is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. Additionally we are shipping MVB12B Antibodies (4) and many more products for this protein.
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Study suggests a novel association between SNPs in FAM125B andintra-ocular pressure in the TwinsUK cohort.
The 1.3-A atomic resolution crystal structure of the MVB12B MABP domain reveals a beta (show SUCLA2 Proteins)-prism fold, a hydrophobic membrane-anchoring loop, and an electropositive phosphoinositide-binding patch.
These results suggest that the expression of MVB12B may be normally suppressed through the ubiquitin-proteasome pathway that simultaneously regulates the fate of MVB12A (show FAM125A Proteins) and the functions of ESCRT-I (show VPS28 Proteins).
The protein encoded by this gene is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. ESCRT-I complex plays an essential role in HIV budding and endosomal protein sorting. Depletion and overexpression of this and related protein (MVB12A) inhibit HIV-1 infectivity and induce unusual viral assembly defects, indicating a role for MVB12 subunits in regulating ESCRT-mediated virus budding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
ESCRT-I complex subunit MVB12B
, family with sequence similarity 125, member B