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Induces rhoa activation and activates nppa transcription and myofibrillar organization through the rho/rock signaling pathway (By similarity). Additionally we are shipping MURC Antibodies (23) and MURC Kits (4) and many more products for this protein.
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murcb mutant zebrafish, display impaired swimming capacity, skeletal muscle fibrosis and T-tubule abnormalities during development.
MURC/cavin-4, especially in combination with Cav-3 (show CAV3 Proteins), may play a consistent role in the differentiation process of rhabdomyosarcoma.
MURC mutations impart loss-of-function effects on MURC functions and probably are causal variants in human dilated cardiomyopathy
MURC modulates RhoA (show RHOA Proteins) signaling, and MURC plays an important role in the development of cardiac dysfunction and conduction disturbance with increased vulnerability to atrial arrhythmias.
The MURC/Cavin-4 in vascular smooth muscle cells modulates abdominal aortic aneurysm (AAA (show AAAS Proteins)) progression at the early stage via the activation of JNK (show MAPK8 Proteins) and MMP-9 (show MMP9 Proteins). MURC/Cavin-4 is a potential therapeutic target against AAA (show AAAS Proteins) progression.
MURC/Cavin-4 facilitates recruitment of ERK (show EPHB2 Proteins) to caveolae and concentric cardiac hypertrophy induced by alpha1-adrenergic receptors.
findings suggest that MURC is involved in the skeletal myogenesis that results from modulation of myogenin (show MYOG Proteins) expression and ERK (show EPHB2 Proteins) activation; MURC may play pivotal roles in the molecular mechanisms of skeletal myogenic differentiation
Data show that MURC/Cavin-4 forms a multiprotein complex that associates with caveolae, and identify Cavin-4 as a novel muscle disease candidate caveolar protein.
Induces rhoa activation and activates nppa transcription and myofibrillar organization through the rho/rock signaling pathway (By similarity).
muscle-related coiled-coil protein
, muscle-restricted coiled-coil protein
, PTRF/SDPR family protein