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Mycn Proteins (MYCN)

MYCN is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. Additionally we are shipping MYCN Antibodies (85) and MYCN Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MYCN 4613 P04198
Rat MYCN MYCN 298894 Q63379
MYCN 18109 P03966
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Top MYCN Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Human His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
Yeast Serinus canaria His tag   1 mg Log in to see 56 to 66 Days
$3,191.83
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$3,234.00
Details

MYCN Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Top referenced MYCN Proteins

  1. Human MYCN Protein expressed in Wheat germ - ABIN1311728 : Smith, Womack: A matrix approach to guide IHC-based tissue biomarker development in oncology drug discovery. in The Journal of pathology 2013 (PubMed)
    Show all 3 references for ABIN1311728

More Proteins for Mycn (MYCN) Interaction Partners

Human Mycn (MYCN) interaction partners

  1. Authors describe an inverse correlation between WT1 (show WT1 Proteins) gene expression and MYCN amplification and expression in neuroblastoma (show ARHGEF16 Proteins) tumors.

  2. The MRN complex is essential to restrain MYCN-induced replication stress during neural cell proliferation.

  3. Oncogenic MYCN re-wires its own interaction and signalling networks to repress regulators of normal cellular developmental processes, such as differentiation.

  4. the expression of MYCN, HMGA2, and DICER1 (show DICER1 Proteins) seems to be correlated to each other and the expression of the let7-genes impacted by their expression.

  5. N-Myc and activated AKT1 (show AKT1 Proteins) are sufficient to transform human prostate epithelial cells to prostate adenocarcinoma and neuroendocrine carcinoma. N-Myc is required for tumor maintenance.

  6. This study strongly suggests that AT7519 is a promising drug for the treatment of high-risk neuroblastoma (show ARHGEF16 Proteins) patients with MYCN amplification.

  7. the MNA (MYCN amplification)subclone appears to be constraint by the tumor environment and thus less relevant for tumor behavior in aggressive tumors with a high genomic instability and many segmental aberrations

  8. SOX2 (show SOX2 Proteins), KCNMB4 (show KCNMB4 Proteins), FOS, GLI3 (show GLI3 Proteins) and GLI1 (show GLI1 Proteins) may be involved in the pathogenesis of neuroblastoma (show ARHGEF16 Proteins), with the expression of SOX2 (show SOX2 Proteins) downregulating the expression of MYCN.

  9. let-7 disruption by LIN28B (show LIN28B Proteins), MYCN sponging, or genetic loss is a unifying mechanism of neuroblastoma (show ARHGEF16 Proteins) development with broad implications for cancer pathogenesis

  10. Suppression of MycN in human neural crest stem cells inhibits cell growth and cell cycle progression.

Mouse (Murine) Mycn (MYCN) interaction partners

  1. Loss of N-myc significantly impairs the Sonic hedgehog (show SHH Proteins) signaling pathway and disrupts the expression of cell cycle effectors with a significant reduction of Ccnd2 (show CCND2 Proteins).

  2. Study shows that ground-state embryonic stem cells express low Myc (show MYC Proteins) levels. Deletion of both c-myc (show MYC Proteins) and N-myc activity strongly decreases transcription, splicing, and protein synthesis, leading to proliferation arrest; process is reversible and occurs without affecting pluripotency, suggesting that Myc (show MYC Proteins)-depleted stem cells enter a state of dormancy.

  3. MYCN overexpression is not sufficient for these cells to form tumors in nude mice

  4. ITGA4 (show ITGA4 Proteins) expression enhances metastasis in MYCN low neuroblastoma (show ARHGEF16 Proteins).

  5. MYCN plays a critical role in expansion and survival of aggressive medulloblastoma-propagating cells.

  6. SUMOylation may be part of a quality-control mechanism acting on misfolded Myc (show MYC Proteins) proteins.

  7. The results of this study provided evidence that N-myc deficiency in the olfactory epithelium progressively diminishes proliferation and neurogenesis with negative consequences at structural and cellular levels.

  8. MYCN/LIN28B/Let-7/HMGA2 pathway implicated by meta-analysis of GWAS in suppression of post-natal proliferation thereby potentially contributing to aging

  9. The above results induced by overexpression of MYCN closely resemble the main aspects of human AML (show RUNX1 Proteins), suggesting that MYCN plays a role in the etiology of AML (show RUNX1 Proteins).

  10. a general mechanism for p53 (show TP53 Proteins) inactivation in some embryonal cell types and consequent susceptibility to MycN oncogenesis at the point of embryonal tumor initiation

MYCN Protein Profile

Protein Summary

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.

Gene names and symbols associated with Mycn Proteins (MYCN)

  • olfactory receptor, family 8, subfamily S, member 1-like (LOC515887)
  • v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN)
  • v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (Mycn)
  • v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (MYCN)
  • v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) (MYCN)
  • v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) (Mycn)
  • bHLHe37 protein
  • c-nmyc protein
  • MODED protein
  • MYCNOT protein
  • N-myc protein
  • Nmuc1 protein
  • Nmyc protein
  • Nmyc-1 protein
  • Nmyc1 protein
  • ODED protein

Protein level used designations for Mycn Proteins (MYCN)

N-myc proto-oncogene protein , class E basic helix-loop-helix protein 37 , neuroblastoma MYC oncogene , neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene , oncogene NMYC , pp65/67 , v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived , v-myc myelocytomatosis viral related oncogene, neuroblastoma derived , Avian myelocytomatosis viral (v-myc) related oncogene neuroblastoma derived (Nmyc) , Avian myelocytomatosis viral (v-myc) related oncogene, neuroblastoma derived (Nmyc) , N-myc protein , neuroblastoma myc-related oncogene 1

GENE ID SPECIES
515887 Bos taurus
4613 Homo sapiens
298894 Rattus norvegicus
421948 Gallus gallus
482978 Canis lupus familiaris
18109 Mus musculus
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