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Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) Proteins (MLL)

MLL encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. Additionally we are shipping Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) Antibodies (86) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MLL 4297 Q03164
MLL 214162 P55200
Rat MLL MLL 315606  
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Top Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 69 Days
$11,073.30
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 69 Days
$11,073.30
Details
HOST_Escherichia coli (E. coli) Human GST tag Recombinant MLL / HRX - SET protein gel. MLL / HRX - SET protein was run on a 10% SDS-PAGE gel and stained with Coomassie blue. 20 μg Log in to see 1 to 2 Days
$466.67
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MLL Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) Interaction Partners

Human Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) interaction partners

  1. This review summarizes and discusses the general mechanisms of H3K4 methylation, and how the six main enzymes from the SET/MLL family (responsible for H3K4me1/me2/me3) function in hematopoiesis and in hematologic malignancies. [review]

  2. Results show that human MLL-AF9 (show MLLT3 Proteins) expression in mouse long-term hematopoietic stem cells causes invasive, chemoresistant acute myeloid leukemia (show BCL11A Proteins) that expresses genes related to epithelial-mesenchymal transition.

  3. Authors evaluated the expression levels of the MLL gene in AML (show RUNX1 Proteins) patients.

  4. Results show that MLL-AF9 (show MLLT3 Proteins) reduces Id2 and increases E2-2 (show TCF4 Proteins) expression to drive and sustain leukemia stem cell potential in MLL-rearranged acute myeloid leukemia (show BCL11A Proteins) (AML (show RUNX1 Proteins)). Low expression of Id2 or of an Id2 gene signature is associated with poor prognosis in not only MLL-rearranged but also t(8;21) AML (show RUNX1 Proteins) patients.

  5. Pygo2 functions as a prognostic factor for glioma due to its up-regulation of H3K4me3 and promotion of MLL1/MLL2 complex recruitment.

  6. MLL mutation is associated with bladder cancer recurrence.

  7. Whereas Set1 targets are largely associated with the maintenance of the stem cell population, MLL1/2 targets are specifically enriched for genes involved in ciliogenesis.

  8. Study shows that MLL-AF9 (show MLLT3 Proteins) influences gene expression involved in cell cycle, Wnt (show WNT2 Proteins) signaling, the cellular response to stress, adhesion as well as myeloid differentiation via miRNA expression.

  9. Data show that lysine-specific demethylase (show MBD2 Proteins) 1 (LSD1 (show KDM1A Proteins)) is a drug target for mixed lineage leukemia (MLL)-rearranged leukemia, and LSD1 (show KDM1A Proteins) inhibitors are potential therapeutics for the malignancy.

  10. Data show that basal-like subgroup was enriched for aggressive tumors and somatic mutations in trithorax (show MLLT1 Proteins)-group genes and it overexpressed polycomb (show CBX2 Proteins) genes EZH2 (show EZH2 Proteins) and CBX2 (show CBX2 Proteins).

Mouse (Murine) Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) interaction partners

  1. Data suggest that RAS-homolog enriched in brain protein (Rheb1) promotes MLL-AF9 fusion protein initiated acute myeloid leukemia (AML) progression through target of rapamycin complex 1 (mTORC1) signaling pathway.

  2. HoxBlinc RNA Recruits Set1/MLL Complexes to Activate Hox (show MSH2 Proteins) Gene Expression Patterns and Mesoderm Lineage Development.

  3. MLL1 and DOT1L (show DOT1L Proteins) cooperate with meningioma-1 to induce acute myeloid leukemia (show BCL11A Proteins).

  4. Set1 role in cellular reprogramming and its interactions with Dpy30 (show DPY30 Proteins),Myc (show MYC Proteins),Sox2 (show SOX2 Proteins) and Ash2l (show ASH2L Proteins) reprogramming factors

  5. The present study examined the mechanism underlying the development of KMT2A (MLL)-rearranged infant leukemia in response to in utero exposure to etoposide in a mouse model.

  6. We have demonstrated that the Mll1 gene is critical to Th1 (show HAND1 Proteins) differentiation in humans and mice

  7. MLL is the key Taspase1 substrate whose cleavage is required for MMTV-neuinduced tumor formation.

  8. Data indicate that Meis homeobox 1 (MEIS1 (show MEIS1 Proteins)) is required for the maintenance of myeloid-lymphoid leukemia protein MLL-fusion gene leukemia, and hepatic leukemia factor (HLF (show HLF Proteins))is a key downstream mediator of Meis1 (show MEIS1 Proteins).

  9. Using a PDK1 (show PDPK1 Proteins) conditional deletion MLL-AF9 (show MLLT3 Proteins) murine AML (show RUNX1 Proteins) model, we revealed that the deletion of PDK1 (show PDPK1 Proteins) prolonged the survival of AML (show RUNX1 Proteins) mice by inducing LSC (show ARHGEF1 Proteins) apoptosis

  10. Recruited MOF (show KAT8 Proteins) activity, and not the intrinsic HMT (show HNMT Proteins) activity of MLL1, is central for the maintenance of HSC (show FUT1 Proteins) target genes. In addition, this work reveals a role for SIRT1 (show SIRT1 Proteins) in opposing MLL1 function.

Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) Protein Profile

Protein Summary

This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with MLL

  • lysine (K)-specific methyltransferase 2A (KMT2A)
  • lysine (K)-specific methyltransferase 2A (Kmt2a)
  • 6430520K01 protein
  • ALL-1 protein
  • All1 protein
  • Cxxc7 protein
  • HRX protein
  • HTRX1 protein
  • mKIAA4050 protein
  • Mll protein
  • MLL/GAS7 protein
  • Mll1 protein
  • MLL1A protein
  • TET1-MLL protein
  • TRX1 protein
  • WDSTS protein

Protein level used designations for MLL

CDK6/MLL fusion protein , CXXC-type zinc finger protein 7 , MLL-AF4 der(11) fusion protein , MLL/GAS7 fusion protein , MLL/GMPS fusion protein , histone-lysine N-methyltransferase 2A , lysine N-methyltransferase 2A , myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) , myeloid/lymphoid or mixed-lineage leukemia protein 1 , trithorax-like protein , zinc finger protein HRX , histone-lysine N-methyltransferase MLL , myeloid/lymphoid or mixed-lineage leukemia 1 , trithorax Drosophila , Mixed-lineage leukemia (also acute lymphocytic leukemia 1 or tritorax Drosophila gene)

GENE ID SPECIES
4297 Homo sapiens
214162 Mus musculus
315606 Rattus norvegicus
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