Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) Proteins (MLL)

MLL encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. Additionally we are shipping Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) Antibodies (52) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MLL 4297 Q03164
MLL 214162 P55200
Rat MLL MLL 315606  
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Top Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
HOST_Escherichia coli (E. coli) Human GST tag Recombinant MLL / HRX - SET protein gel. MLL / HRX - SET protein was run on a 10% SDS-PAGE gel and stained with Coomassie blue. 20 μg Log in to see 1 to 2 Days
$466.67
Details

MLL Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) Interaction Partners

Human Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) interaction partners

  1. MLL rearrangement is associated with infant acute lymphoblastic leukemia.

  2. These results reveal a cooperative transcriptional activation mechanism of AEP (show LGMN Proteins) and DOT1L (show DOT1L Proteins) and suggest a molecular rationale for the simultaneous inhibition of the MLL fusion-AF4 complex and DOT1L (show DOT1L Proteins) for more effective treatment of MLL-rearranged leukemia.

  3. this indicates that DOT1L (show DOT1L Proteins) function, like MLL, does not completely rely on its methyltransferase activity. Nevertheless, the small molecule DOT1L (show DOT1L Proteins) inhibition is sufficient to block the proliferation of MLL fusion-induced leukemia cells of murine and human origin

  4. Studies demonstrate that histone methyl-transferase MLL1 coordinates with HIF1alpha (show HIF1A Proteins) and histone acetyltransferase p300 (show EP300 Proteins) and regulate hypoxia-induced HOTAIR expression. The hypoxia-induced upregulation of HOTAIR expression may contribute to its roles in tumorigenesis.

  5. MLL1 and MLL2 collaborate to regulate gene expression and leukemia maintenance not through redundancy, but through distinct pathways.

  6. MLL1, deposits H3K4me2 at CpG-dense regions that could serve as polycomb (show CBX2 Proteins) response elements.

  7. A patient was diagnosed with Wiedemann-Steiner syndrome based on identification of a novel de novo pathogenic variant in the KMT2A gene.

  8. MLL gene rearrangement is associated with acute lymphocytic leukemia.

  9. Our data thus extend MLL1 function to H3K4 methylation and PD-L1 (show CD274 Proteins) transcription activation in pancreatic cancer cells.

  10. KMT2A gene rearrangement is associated with acute megakaryoblastic leukemia in non-Down syndrome.

Mouse (Murine) Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) interaction partners

  1. These results reveal a cooperative transcriptional activation mechanism of AEP (show LGMN Proteins) and DOT1L (show DOT1L Proteins) and suggest a molecular rationale for the simultaneous inhibition of the MLL fusion-AF4 complex and DOT1L (show DOT1L Proteins) for more effective treatment of MLL-rearranged leukemia.

  2. This study demonstrated that Kmt2a regulates synaptic plasticity in striatal neurons and provides an epigenetic drug target for anxiety and dopamine-mediated behaviors.

  3. Inactivation of Kmt2a in Men1-deficient mice accelerated pancreatic islet tumorigenesis and shortened the average life span. Increases in cell proliferation were observed in mouse pancreatic islet tumors upon inactivation of both Kmt2a and Men1.

  4. Data suggest that RAS-homolog enriched in brain protein (Rheb1) promotes MLL-AF9 fusion protein initiated acute myeloid leukemia (AML) progression through target of rapamycin complex 1 (mTORC1) signaling pathway.

  5. HoxBlinc RNA Recruits Set1/MLL Complexes to Activate Hox (show MSH2 Proteins) Gene Expression Patterns and Mesoderm Lineage Development.

  6. MLL1 and DOT1L (show DOT1L Proteins) cooperate with meningioma-1 to induce acute myeloid leukemia (show BCL11A Proteins).

  7. Set1 role in cellular reprogramming and its interactions with Dpy30 (show DPY30 Proteins),Myc (show MYC Proteins),Sox2 (show SOX2 Proteins) and Ash2l (show ASH2L Proteins) reprogramming factors

  8. The present study examined the mechanism underlying the development of KMT2A (MLL)-rearranged infant leukemia in response to in utero exposure to etoposide in a mouse model.

  9. We have demonstrated that the Mll1 gene is critical to Th1 (show HAND1 Proteins) differentiation in humans and mice

  10. MLL is the key Taspase1 substrate whose cleavage is required for MMTV-neuinduced tumor formation.

Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) Protein Profile

Protein Summary

This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with MLL

  • lysine (K)-specific methyltransferase 2A (KMT2A)
  • lysine (K)-specific methyltransferase 2A (Kmt2a)
  • 6430520K01 protein
  • ALL-1 protein
  • All1 protein
  • Cxxc7 protein
  • HRX protein
  • HTRX1 protein
  • mKIAA4050 protein
  • Mll protein
  • MLL/GAS7 protein
  • Mll1 protein
  • MLL1A protein
  • TET1-MLL protein
  • TRX1 protein
  • WDSTS protein

Protein level used designations for MLL

CDK6/MLL fusion protein , CXXC-type zinc finger protein 7 , MLL-AF4 der(11) fusion protein , MLL/GAS7 fusion protein , MLL/GMPS fusion protein , histone-lysine N-methyltransferase 2A , lysine N-methyltransferase 2A , myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) , myeloid/lymphoid or mixed-lineage leukemia protein 1 , trithorax-like protein , zinc finger protein HRX , histone-lysine N-methyltransferase MLL , myeloid/lymphoid or mixed-lineage leukemia 1 , trithorax Drosophila , Mixed-lineage leukemia (also acute lymphocytic leukemia 1 or tritorax Drosophila gene)

GENE ID SPECIES
4297 Homo sapiens
214162 Mus musculus
315606 Rattus norvegicus
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