anti-Myocilin (MYOC) Antibodies

MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. Additionally we are shipping Myocilin Proteins (23) and Myocilin Kits (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MYOC 17926 O70624
MYOC 4653 Q99972
MYOC 81523 Q9R1J4
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Top anti-Myocilin Antibodies at antibodies-online.com

Showing 10 out of 60 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Guinea Pig Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, IHC (p) 50 μg Log in to see 6 to 8 Days
$500.50
Details
Mouse Rabbit Un-conjugated IHC, WB 100 μL Log in to see 13 to 14 Days
$302.50
Details
Human Mouse Un-conjugated EIA, IHC (p), WB 50 μg Log in to see 6 to 8 Days
$566.50
Details
Human Rabbit Un-conjugated ELISA, IHC (p) Immunohistochemistry-Paraffin: Myocilin Antibody [NBP1-40064] - Analysis of anti-MYOC antibody with human eye, retina at concentration 5 ug/ml. 0.05 mg Log in to see 7 to 9 Days
$447.56
Details
Human Mouse Un-conjugated WB Western blot analysis of MYOC over-expressed 293 cell line, cotransfected with MYOC Validated Chimera RNAi used as specificity and loading control. Western Blot analysis of MYOC expression in transfected 293T cell line by MYOC monoclonal antibody (M01), clone 4F8. Lane 1: MYOC transfected lysate(57 KDa). Lane 2: Non-transfected lysate. 50 μg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated WB Western Blot analysis of MYOC expression in transfected 293T cell line by MYOC monoclonal antibody (M02), clone 2B4. Lane 1: MYOC transfected lysate(57 KDa). Lane 2: Non-transfected lysate. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Gibbon Rabbit Un-conjugated IHC, ELISA 0.05 mg Log in to see 2 to 3 Days
$515.63
Details
Human Mouse Un-conjugated IHC (p), RNAi, ELISA, WB Human Vessel: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 7 to 9 Days
$511.50
Details
Human Rabbit Un-conjugated WB   200 μL Log in to see 13 to 14 Days
$487.50
Details

MYOC Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine)


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Human , ,
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, , , , ,
Rat (Rattus)


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More Antibodies against Myocilin Interaction Partners

Mouse (Murine) Myocilin (MYOC) interaction partners

  1. mutant myocilin induces abnormal ECM (show MMRN1 Antibodies) accumulation in the ER of TM cells, which may be responsible for reduced outflow facility and IOP elevation in myocilin-associated glaucoma.

  2. Mutated myocilin and heterozygous Sod2 (show SOD2 Antibodies) deficiency act synergistically in a mouse model of open-angle glaucoma

  3. myocilin promotes cell proliferation and resistance to apoptosis via the ERK1/2 (show MAPK1/3 Antibodies) MAPK (show MAPK1 Antibodies) signaling pathway.

  4. Myocilin binds to ErbB2 (show ERBB2 Antibodies)/ErbB3 (show ERBB3 Antibodies), activates these receptors, and affects the downstream PI3K-AKT (show AKT1 Antibodies) signaling pathway

  5. Myocilin also stimulated osteogenic differentiation of wild-type MSCs, which was associated with activation of the p38 (show CRK Antibodies), Erk1/2 (show MAPK1/3 Antibodies), and JNK (show MAPK8 Antibodies) MAP kinase (show MAPK1 Antibodies) signaling pathways

  6. We suggest that intracellular myocilin plays a role as a regulator of muscle hypertrophy pathways, acting through the components of dystrophin (show DMD Antibodies) associated protein complex.

  7. The TIGR is implicated in resistance to oxidative stress. Despite the presence of a SOD motif, which is necessary for protection in mammalian cells, the protein is not a functional SOD, but might be involved in SOD activity.

  8. TIGR is a newly identified component of the CNS glial scar that is likely to contribute to neuronal regenerative failure characteristic of the mammalian CNS.

  9. Results do not support a causative role for increased MYOC levels or the MYOC gene in steroid-induced glaucoma.

  10. Results show that myocilin and gamma-synuclein interact and as a result, myocilin's properties are changed.

Human Myocilin (MYOC) interaction partners

  1. present work reveals that FOXC1 (show FOXC1 Antibodies) is an important regulator of exocytosis and establishes a new link between FOXC1 (show FOXC1 Antibodies) and MYOC-associated glaucoma

  2. The four detected MYOC mutations appeared to be associated with morphologic changes in the trabecular meshwork and the underlying pathogenesis of a subtype of familial primary open angle glaucoma.

  3. The mutations c.1456C < T (p.L486F) in MYOC and c.322G < A (p.V108I) in B4GALT3 (show B4GALT3 Antibodies) are likely responsible for the pathogenesis of Primary Open-angle Glaucoma in this family.

  4. Our findings demonstrated that MYOC cascade genetic testing for POAG allows identification of at-risk individuals at an early stage or even before signs of glaucoma are present. To our knowledge, this is the first study to demonstrate the clinical utility of predictive genetic testing for MYOC glaucoma.

  5. regulation by retinoic acid acts through the MYOC promoter which contains a critical cluster of four retinoic acid responsive (show GPRC5A Antibodies) elements (RAREs), with the RARE-DR2 presenting the strongest effect and binding the RARalpha (show RARA Antibodies)/RXRalpha (show RXRA Antibodies) heterodimer.

  6. Five out of 30 families with PCG (16.7%) had disease attributable to CYP1B1 (show CYP1B1 Antibodies) alterations suggesting that CYP1B1 (show CYP1B1 Antibodies) is not the major gene causing PCG in Vietnamese unlike in the case of Arab or Romany patients.

  7. The present study provides insight into the genetic or haplotype variants of MYOC and OPTN (show OPTN Antibodies) genes contributing to primary glaucoma. Haplotype variants identified in the present study may be regarded as potential contributing factors of primary glaucoma in Korea.

  8. Familial linkage studies for primary angle-closure glaucoma have been performed and identified MYOC causative primary angle-closure glaucoma disease

  9. The rate of CYP1B1 (show CYP1B1 Antibodies) mutations in Lebanese patients with primary congenital glaucoma (PCG) is lower than that reported in other Arab and Middle Eastern populations and suggests other genes are responsible.

  10. Data show that predictive genetic testing for early onset Myocilin glaucoma can facilitate early detection of disease or discharge from routine ophthalmic examinations.

Cow (Bovine) Myocilin (MYOC) interaction partners

  1. endoproteolytic processing might regulate the activity of myocilin; the inhibition of the processing by pathogenic mutations impairs the normal role of myocilin

Myocilin (MYOC) Antigen Profile

Protein Summary

MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma.

Gene names and symbols associated with anti-Myocilin (MYOC) Antibodies

  • myocilin (MYOC) antibody
  • myocilin (myoc) antibody
  • myocilin (Myoc) antibody
  • AI957332 antibody
  • GLC1A antibody
  • GPOA antibody
  • JOAG antibody
  • JOAG1 antibody
  • MGC136645 antibody
  • MYOC antibody
  • myocilin antibody
  • Tigr antibody
  • zgc:136645 antibody

Protein level used designations for anti-Myocilin (MYOC) Antibodies

myocilin , trabecular meshwork-induced glucocorticoid response protein , mutated trabecular meshwork-induced glucocorticoid response protein

GENE ID SPECIES
397046 Sus scrofa
548602 Danio rerio
704406 Macaca mulatta
17926 Mus musculus
4653 Homo sapiens
81523 Rattus norvegicus
281342 Bos taurus
101087632 Felis catus
490344 Canis lupus familiaris
100008897 Oryctolagus cuniculus
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