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The product of MEF2B is a member of the MADS/MEF2 family of DNA binding proteins. Additionally we are shipping Myocyte Enhancer Factor 2B Antibodies (47) and Myocyte Enhancer Factor 2B Kits (1) and many more products for this protein.
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Mef2 (show MYEF2 Proteins) controls skeletal muscle formation after terminal differentiation.
Whereas MEF2A (show MEF2A Proteins) is absolutely required for proper myoblast differentiation, MEF2B, -C, and -D were found to be dispensable for this process.
Calcineurein regulates skeletal muscle differentiation by activating MEF2 (show MEF2C Proteins) and MyoD (show MYOD1 Proteins) transcription factors.
Myocyte enhancer factor-2 and serum response factor binding elements regulate fast Myosin heavy chain (show MYH8 Proteins) transcription in vivo
K4E, Y69H and D83V mutations decrease the capacity of MEF2B to activate transcription and decrease its effects on cell migration.
Epstein-Barr Virus EBNA1 (show EBNA-1 Proteins) bound to host genes of high significance for B-cell growth and function, including MEF2B, IL6R (show IL6R Proteins), and EBF1 (show EBF1 Proteins).
We conclude that MEF2B is a valuable marker of normal germinal center B cells, potentially useful in differential diagnosis of small B cell lymphomas.
MEF2B mutations lead to deregulated expression of the oncogene (show RAB1A Proteins) BCL6 (show BCL6 Proteins) in diffuse large B cell lymphoma.
MEF2B has a role in myogenic transformation of the epithelial to a myofibroblast phenotype
The phylogenetic tree result shows that MEF2B may be original because of its difference of sequences and evolutional relation.
32% of diffuse large B-cell lymphoma and 89% of follicular lymphoma cases had somatic mutations in MLL2, and 11.4% and 13.4% of DLBCL and FL cases, respectively, had mutations in MEF2B
Crystal structure of the MADS-box/MEF2S domain of human MEF2B bound to a motif of the transcriptional co-repressor Cabin1 (show CABIN1 Proteins) and DNA at 2.2 A resolution
myogenin (show MYOG Proteins) and myocyte enhancer factor-2 expression are triggered by membrane hyperpolarization during human myoblast differentiation
The crystal structure of a histone deacetylase 9 (HDAC9 (show HDAC9 Proteins))/myocyte enhancer factor-2 (MEF2 (show MEF2A Proteins))/DNA complex reveals that HDAC9 (show HDAC9 Proteins) binds to a hydrophobic groove of the MEF2 (show MEF2A Proteins) dimer.
This study provides new evidence of the significant role played by Mef2B in the postnatal muscle growth and development in cattle, and indicates that Mef2B can be a promising molecular marker for carcass quality-related traits in adult cattle.
The product of this gene is a member of the MADS/MEF2 family of DNA binding proteins. The protein is thought to regulate gene expression, including expression of the smooth muscle myosin heavy chain gene. This region undergoes considerable alternative splicing, with transcripts supporting two non-overlapping loci (geneID:729991 and 100271849) as well as numerous read-through transcripts that span both loci (annotated as geneID:4207). Several isoforms of this protein are expressed from either this locus or from some of the read-through transcripts annotated on geneID:4207.
myocyte-specific enhancer factor 2B
, MADS box transcription enhancer factor 2, polypeptide B (myocyte enhancer factor 2B)
, serum response factor-like protein 2