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Mutations in dysferlin, a protein associated with the plasma membrane, can cause muscle weakness that affects both proximal and distal muscles. Additionally we are shipping Myoferlin Antibodies (21) and and many more products for this protein.
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the cleavage of myoferlin, yielding a membrane-associated dual C2 domain 'mini-myoferlin', is reported.
A novel regulator, myoferlin, of ADAM12 (show ADAM12 ELISA Kits) is discovered in HeLa cells and this protein increases ADAM12 (show ADAM12 ELISA Kits) expression level, stability, and its enzymatic activity, leading to the reduction of its substrate, E-cadherin (show CDH1 ELISA Kits), which plays important roles in the regulation of cell adhesion and tumor metastasis.
Data show myoferlin depletion did not affect STAT3 (show STAT3 ELISA Kits) transcription factor (STAT3 (show STAT3 ELISA Kits)) phosphorylation, but completely blocked STAT3 (show STAT3 ELISA Kits) translocation to nucleus.
This study is the first to report robust age associations for DNA methylation (show HELLS ELISA Kits) in MYOF and DDO (show DDO ELISA Kits), both of which have plausible functional roles in aging
Results demonstrate for the first time that nuclear myoferlin expression independently predicts poor clinical outcome in OPSCC patients.
Myoferlin plays a key role in VEGFA (show VEGFA ELISA Kits) secretion and impacts tumor-associated angiogenesis in human pancreas cancer.
MYOF regulates cell adhesions and cell-substrate adhesion strength and may account for the high degree of motility in invasive breast cancer cells.
These data provide the first evidence of myoferlin expression in solid human and mouse tumors.
Data indicate that dysferlin (show DYSF ELISA Kits), otoferlin (show OTOF ELISA Kits), and myoferlin do not merely passively adsorb to membranes but actively sculpt lipid bilayers.
High myoferlin expression is associated with breast cancer.
these findings demonstrate the importance of dysferlin (show DYSF ELISA Kits) and myoferlin for transverse tubule function and in the genesis of muscular dystrophy.
Myoferlin gene knockdown not only decreases lipid vesicle fusion in EC but also attenuates Vascular Endothelial Growth Factor (VEGF) Receptor-2 (VEGFR-2) expression.
IGF1 (show IGF1 ELISA Kits) receptor recycling is required for normal myogenesis and myoferlin is a critical mediator of postnatal muscle growth mediated by IGF1 (show IGF1 ELISA Kits)
Calcium-sensitive phospholipid binding properties of normal and mutant ferlin C2 domains. (myoferlin)
myoferlin plays role in the maturation of myotubes and the formation of large myotubes that arise from the fusion of myoblasts to multinucleate myotubes.
myoferlin forms a complex with dynamin-2 (show DNM2 ELISA Kits) and VEGFR-2 (show KDR ELISA Kits), which prevents CBL (show CBL ELISA Kits)-dependent VEGFR-2 (show KDR ELISA Kits) polyubiquitination and proteasomal degradation.
interaction of myoferlin with EHD2 (show EHD3 ELISA Kits) identifies molecular overlap between the endocytic recycling pathway and the machinery that regulates myoblast membrane fusion
Mutations in dysferlin, a protein associated with the plasma membrane, can cause muscle weakness that affects both proximal and distal muscles. The protein encoded by this gene is a type II membrane protein that is structurally similar to dysferlin. It is a member of the ferlin family and associates with both plasma and nuclear membranes. The protein contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. Two transcript variants encoding different isoforms have been found for this gene. Other possible variants have been detected, but their full-length nature has not been determined.
fer-1-like 3, myoferlin
, Fer-1-like protein 3
, fer-1-like protein 3