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Binds to myosin\; probably involved in interaction with thick myofilaments in the A-band. Additionally we are shipping Myosin Binding Protein H Proteins (5) and Myosin Binding Protein H Kits (4) and many more products for this protein.
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Human Monoclonal MYBPH Primary Antibody for ELISA, WB - ABIN561890
Chelh, Meunier, Picard, Reecy, Chevalier, Hocquette, Cassar-Malek: Molecular profiles of Quadriceps muscle in myostatin-null mice reveal PI3K and apoptotic pathways as myostatin targets. in BMC genomics 2009
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Human Polyclonal MYBPH Primary Antibody for WB - ABIN2786789
Welikson, Fischman: The C-terminal IgI domains of myosin-binding proteins C and H (MyBP-C and MyBP-H) are both necessary and sufficient for the intracellular crosslinking of sarcomeric myosin in transfected non-muscle cells. in Journal of cell science 2002
Show all 2 references for ABIN2786789
variation in MYBPH can modulate the severity of hypertrophy in hypertrophic cardiomyopathy patients.
MyBP-H expression signals the onset of dysregulation in actin-myosin interaction; this in turn might contribute to the pathogenesis of amyotrophic lateral sclerosis.
These results suggest that MYBPH inhibits RLC and NMHC IIA, independent components of NM IIA, and negatively regulates actomyosin organization at 2 distinct steps, resulting in firm inhibition of NM IIA assembly.
MYBPH inhibited assembly competence-conferring phosphorylation of the myosin regulatory light chain (RLC) as well as activating phosphorylation of LIM (show PDLIM5 Antibodies) domain kinase, unexpectedly through its direct physical interaction with Rho kinase (show ROCK1 Antibodies) 1
Binds to myosin\; probably involved in interaction with thick myofilaments in the A-band.
myosin binding protein H
, myosin-binding protein H-like
, myosin-binding protein H
, norvegicus myosin binding protein H
, 86 kDa protein
, myosin binding protein-H