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Myosin Heavy Chain 7, Cardiac Muscle, beta Proteins (MYH7)

Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. Additionally we are shipping Myosin Heavy Chain 7, Cardiac Muscle, beta Antibodies (54) and Myosin Heavy Chain 7, Cardiac Muscle, beta Kits (22) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MYH7 4625 P12883
Rat MYH7 MYH7 29557 P02564
Mouse MYH7 MYH7 140781 Q91Z83
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Top Myosin Heavy Chain 7, Cardiac Muscle, beta Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$774.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Primates His tag   1 mg Log in to see 56 to 66 Days
$2,623.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
$914.38
Details

MYH7 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,

More Proteins for Myosin Heavy Chain 7, Cardiac Muscle, beta (MYH7) Interaction Partners

Human Myosin Heavy Chain 7, Cardiac Muscle, beta (MYH7) interaction partners

  1. Study shows lack of phenotypic differences between MYH7- and MYBPC3 (show MYBPC3 Proteins)-associated hypertrophic cardiomyopathy when assessed by cardiac magnetic resonance imaging.

  2. Two novel heterozygous proline substitutions located in exon 31 of MYH7 within its rod domain:c.4309G>C (p.Ala1437Pro) and c.4301G>C (p.Arg1434Pro) is causing skeletal myopathies.

  3. MYBPC3 (show MYBPC3 Proteins) and MYH7 were the most common mutated genes, accounting for 27% of the total Hypertrophic Cardiomyopathy patients and 83% of the putative mutations in the main sarcomeric genes.

  4. MYH7 gene mutation is associated with Early-Onset Hypertrophic Cardiomyopathy.

  5. family members who carried both the MYH7-A719H and MYOZ2 (show MYOZ2 Proteins)-L169G mutations had more severe symptoms of hypertrophic cardiomyopathy, including sudden cardiac death, than those with only the MYH7 mutation

  6. Chinese family with dual LQT1 (show KCNQ1 Proteins) and HCM phenotypes associated with tetrad heterozygous mutations in KCNQ1 (show KCNQ1 Proteins), MYH7, MYLK2 (show MYLK2 Proteins), and TMEM70 (show TMM70 Proteins) mutations.

  7. A novel heterozygous mutation (MYH7, p.Asn885Thr), and a variant of uncertain significance (TNNT2 (show TNNT2 Proteins), p.Arg296His) were identified in 2 patients with familial hypertrophic cardiomyopathy.

  8. Multidimensional structure-function relationships in human beta-cardiac myosin from population-scale genetic variation.

  9. BNP, but not mutations in MYH7 may have a role in sudden cardiac death in children with hypertrophic cardiomyopathy

  10. 5 out of 102 (4.9%) athletes carried mutations: a heterozygous MYH7 Glu935Lys mutation, a heterozygous MYBPC3 (show MYBPC3 Proteins) Arg160Trp mutation and another heterozygous MYBPC3 (show MYBPC3 Proteins) Thr1046Met mutation, all of which had been reported as HCM-associated mutations

Cow (Bovine) Myosin Heavy Chain 7, Cardiac Muscle, beta (MYH7) interaction partners

  1. Tm affects the conformation of actin so as to increase the area of hydrophobic interaction between actin and myosin molecules

Pig (Porcine) Myosin Heavy Chain 7, Cardiac Muscle, beta (MYH7) interaction partners

  1. Myosin regulatory light chain phosphorylation enhances cardiac beta-myosin in vitro motility under load.

  2. Mutation analysis of MYH7 gene revealed an in-frame insertion within exon 30 of MYH7 which was perfectly associated with the disease phenotype and confirmed the dominant inheritance.

Mouse (Murine) Myosin Heavy Chain 7, Cardiac Muscle, beta (MYH7) interaction partners

  1. The promoter regions of the SERCA (show ATP2A3 Proteins)-2A and beta-MHC genes, Atp2a2 (show ATP2A2 Proteins) and Myh7, respectively in murine hearts after one or eight weeks of pressure overload induced by transverse aortic constriction, were evaluated.

  2. Foxo1 (show FOXO1 Proteins) has important roles in promoting diabetic cardiomyopathy and controls beta-MHC expression in the development of cardiac dysfunction.

  3. Cooperative/allosteric effects on actomyosin crossbridge recruitment dynamics are increased by beta-MHC.

  4. Reexpression of bMHC is associated at the bMHC promoter with increased H3ac but not H3K4me3.

  5. Metabolic and myosin isoform gene expression switch in sepsis-induced myocardial depression is inducible nitric oxide synthase (show NOS2 Proteins)-dependent.

  6. residues situated within or close to the actin-binding interface of the myosin head influence actin binding and thereby modulate actin-activated ATPase activity

  7. Simultaneous defects in MHC7 & TnI (show TNNI2 Proteins) accelerate onset & progression of familial hypertrophic cardiomyopathy. Compared with single-mutant models, double-mutant mice develop severe disease & premature death, progressing directly to a dilated phenotype.

  8. the functional consequences of the mutation are fundamentally changed depending upon the context of the cardiac MHC isoform.

Myosin Heavy Chain 7, Cardiac Muscle, beta (MYH7) Protein Profile

Protein Summary

Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy.

Gene names and symbols associated with MYH7

  • myosin, heavy chain 7, cardiac muscle, beta (MYH7)
  • myosin, heavy chain 16 (MYH16)
  • myosin, heavy chain 7, cardiac muscle, beta (Myh7)
  • myosin, heavy polypeptide 7, cardiac muscle, beta (Myh7)
  • slow myosin heavy chain 1 (SM1)
  • AMHC1 protein
  • B-MHC protein
  • beta-MHC protein
  • CMD1S protein
  • CMH1 protein
  • MPD1 protein
  • Myhc-b protein
  • MyHC-I protein
  • Myhcb protein
  • myosin protein
  • myosin-7 protein
  • SPMD protein
  • SPMM protein

Protein level used designations for MYH7

cardiac muscle , chick atrial myosin heavy chain , heavy polypeptide 7 , myosin heavy chain , myosin, heavy polypeptide 7, cardiac muscle, beta , myosin-7 , masticatory myosin heavy chain 16 , beta-myosin heavy chain , myHC-beta , myhc-slow , myopathy, distal 1 , myosin heavy chain (AA 1-96) , myosin heavy chain 7 , myosin heavy chain slow isoform , myosin heavy chain, cardiac muscle beta isoform , rhabdomyosarcoma antigen MU-RMS-40.7A , beta myosin heavy chain , myHC-slow , myosin heavy chain polypeptide 7 cardiac muscle fetal , myosin heavy chain, cardiac muscle, fetal , myosin heavy chain, polypeptide 7 , type slow/beta myosin heavy chain , beta cardiac myosin heavy chain , myosin 7 , myosin heavy chain slow type 1 (beta cardiac) , MYH-beta/slow , cardiac myosin heavy chain beta

GENE ID SPECIES
395350 Gallus gallus
489862 Canis lupus familiaris
4625 Homo sapiens
29557 Rattus norvegicus
282714 Bos taurus
403807 Canis lupus familiaris
791234 Equus caballus
396860 Sus scrofa
100101566 Oryctolagus cuniculus
140781 Mus musculus
396063 Gallus gallus
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