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The protein encoded by MYO18B may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm.
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Full loss of myo18b function results in a complete lack of sarcomeric structure, revealing a highly surprising and essential role for myo18b in sarcomere assembly. Importantly, scattered thin and thick filaments assemble throughout the sarcoplasm. These observations suggest a novel model of sarcomere assembly where Myo18b coordinates the integration of preformed thick and thin filaments into the sarcomere
Deficiency of MYO18B is linked to a novel developmental disorder which combines KFA (show AFMID Antibodies) with myopathy.
No associations were found between rs133885 in myosin-18B and mathematical abilities among individuals with dyslexia or in the general population.
A common MYO18B variant is associated with mathematical disability in children with dyslexia and with intraparietal sulcus variability in neurotypical adults.
Human MYO18B, a novel unconventional myosin heavy chain (show DNAH8 Antibodies) expressed in striated (show NSDHL Antibodies) muscles moves into the myonuclei upon differentiation
MYO18B alterations, including both epigenetic and genetic alterations, play an important role in ovarian carcinogenesis
Proteasome dysfunction by a proteasome inhibitor or siRNA-mediated knock-down of Sug1 (show PSMC5 Antibodies) caused the up-regulation of MYO18B protein and MYO18B was polyubiquitinated in vivo.
The restored expression of MYO18B may be a useful therapeutic strategy for the treatment of locally advanced Malignant pleural mesothelioma(MPM)in humans.
Expression of HOMER2 (show HOMER2 Antibodies) enhanced the ability of MYO18B to suppress anchorage-independent growth. These results indicate that HOMER2 (show HOMER2 Antibodies) and MYO18B cooperate together in tumor suppression.
Myo18B is a unique unconventional myosin (show MYO6 Antibodies) that is predominantly expressed in myocytes and whose expression is essential for the development and/or maintenance of myofibrillar structure.
The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer.
, myosin 18B
, unconventional myosin-XVIIIb