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N-Acetyltransferase 1 (Arylamine N-Acetyltransferase) Proteins (NAT1)

NAT1 is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. Additionally we are shipping NAT1 Antibodies (73) and NAT1 Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NAT1 171362  
NAT1 17960 P50294
NAT1 9 P18440
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Top NAT1 Proteins at antibodies-online.com

Showing 10 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$407.00
Details
Yeast Cat His tag   1 mg Log in to see 56 to 66 Days
$2,665.67
Details
Yeast Mesocricetus auratus His tag   1 mg Log in to see 56 to 66 Days
$2,764.67
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,764.67
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$2,764.67
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,764.67
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$467.86
Details

NAT1 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Mouse (Murine)

Human ,
,

Top referenced NAT1 Proteins

  1. Human NAT1 Protein expressed in Escherichia coli (E. coli) - ABIN667924 : Gu, Liang, Wang, Lu, Wu: Effects of N-acetyl transferase 1 and 2 polymorphisms on bladder cancer risk in Caucasians. in Mutation research 2005 (PubMed)
    Show all 2 references for ABIN667924

  2. Human NAT1 Protein expressed in Wheat germ - ABIN1311997 : Millner, Doll, Cai, States, Hein: Phenotype of the most common "slow acetylator" arylamine N-acetyltransferase 1 genetic variant (NAT1*14B) is substrate-dependent. in Drug metabolism and disposition: the biological fate of chemicals 2011 (PubMed)
    Show all 2 references for ABIN1311997

More Proteins for N-Acetyltransferase 1 (Arylamine N-Acetyltransferase) (NAT1) Interaction Partners

Mouse (Murine) N-Acetyltransferase 1 (Arylamine N-Acetyltransferase) (NAT1) interaction partners

  1. Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 (show NAT2 Proteins) defined by substrate specificity and inhibitor binding.(

  2. In adipocytes, Nat1 (show EIF4G2 Proteins) silencing lowered insulin (show INS Proteins)-mediated glucose uptake, raised lipolysis, and decreased differentiation. Overexpression did the opposite. Nat1 (show EIF4G2 Proteins)(-) mice had high fasting blood glucose, insulin (show INS Proteins), and triglycerides and low insulin (show INS Proteins) sensitivity.

  3. Transfection assays in mice using hydrodynamics-based procedure and reporter gene assay in a mouse cell line revealed that glucocorticoid-induced NAT (show BRD2 Proteins) gene expression is species dependent

  4. NAT1 (show EIF4G2 Proteins) affects cell growth and morphology

  5. Biochemical analysis demonstrated that mNAT1 and its evolutionarily conserved co-subunit, mARD1, assemble to form a functional acetyltransferase.

  6. Results suggest that peroxynitrite-dependent inactivation of NAT1 (show EIF4G2 Proteins) and 2 may contribute to muscle dysfunction by impairing the biotransformation activity of this key cellular defense enzyme system.

Human N-Acetyltransferase 1 (Arylamine N-Acetyltransferase) (NAT1) interaction partners

  1. NAT1 (show EIF4G2 Proteins) genotype affects thioguanine nucleotide levels in patients treated with thiopurines and aminosalicylates and could therefore influence the toxicity and efficacy of these drugs.

  2. NAT1 (show EIF4G2 Proteins) genetic polymorphisms were found to be a risk factor for smokers in the Black population of South Africa with esophageal squamous cell carcinoma.

  3. NAT1 (show EIF4G2 Proteins) has a role in the metabolic pathway of nicotine/cotinine and/or their metabolites.

  4. We report that miR (show MLXIP Proteins)-1290 directly targets the NAT1 (show EIF4G2 Proteins) 3'-UTR and that NAT1 (show EIF4G2 Proteins) protein expression is correlated with improved OS of breast cancer patients.

  5. Arylamine N-acetyltransferase polymorphisms in Han Chinese patients with ankylosing spondylitis and their correlation to the adverse drug reactions to sulfasalazine

  6. Candidate gene NAT1 (show EIF4G2 Proteins) were elevated in male breast cancer biopsies compared to those from female patients without regard to Estrogen Receptors status.

  7. Data suggest that NAT1 (show EIF4G2 Proteins)/NAT2 participate in biotransformation of many aromatic/heterocyclic amines; molecular models have been developed regarding acetylation mechanism, active site structure, and substrate/inhibitor-binding specificity. [REVIEW]

  8. Epidemiological studies suggest that the NAT1 (show EIF4G2 Proteins) and NAT2 acetylation polymorphisms modify the risk of developing cancers of the urinary bladder, colorectal, breast, head and neck, and lung

  9. the present study provides evidence for the role of NAT1 (show EIF4G2 Proteins) and NAT2 variations in NSCLP, and indicates that interactions between the NAT1 (show EIF4G2 Proteins) and NAT2 genes may be important in susceptibility to NSCLP.

  10. NAT1 (show EIF4G2 Proteins) rapid acetylation alone as well as combination of NAT1 (show EIF4G2 Proteins) rapid-NAT2 slow acetylation did not modulate the risk of oral precancer and cancer in an Indian patient population.

NAT1 Protein Profile

Protein Summary

This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with NAT1

  • eukaryotic translation initiation factor 4, gamma 2, pseudogene 1 (Eif4g2-ps1)
  • N-acetyl transferase 1 (Nat1)
  • N-acetyltransferase 1 (Nat1)
  • N-acetyltransferase 1 (arylamine N-acetyltransferase) (NAT1)
  • N-acetyltransferase 1 (arylamine N-acetyltransferase) (Nat1)
  • solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 (SLC6A2)
  • AAC1 protein
  • AT-I protein
  • DRCF-6 protein
  • Eif4g2 protein
  • MNAT protein
  • Nat protein
  • NAT-1 protein
  • NAT1 protein
  • NATI protein

Protein level used designations for NAT1

N(alpha)-acetyltransferase 15, NatA auxiliary subunit , N-acetyl transferase 1, liver, blood , N-acetyltransferase type 1 , arylamide acetylase 1 , arylamine N-acetyltransferase 1 , AT-1 , N-acetyltransferase (arylamine N-acetyltransferase) , N-acetyltransferase 1 (arylamine N-acetyltransferase) , NAT-1 , monomorphic arylamine N-acetyltransferase , Arylamide acetylase 1 , Monomorphic arylamine N-acetyltransferase , NAT1 9 , acetyltransferase AT-I , arylamine acetyltransferase , MNAT , N-acetyltransferase 1 , arylamine N-acetyltransferase

GENE ID SPECIES
171362 Rattus norvegicus
17960 Mus musculus
116631 Rattus norvegicus
9 Homo sapiens
512603 Bos taurus
101095575 Felis catus
101840278 Mesocricetus auratus
100328959 Oryctolagus cuniculus
493768 Felis catus
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