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NOX3 encodes a member of the NOX family of NADPH oxidases. Additionally we are shipping NOX3 Proteins (6) and NOX3 Kits (1) and many more products for this protein.
Showing 10 out of 55 products:
Human Polyclonal NOX3 Primary Antibody for IHC, ELISA - ABIN1535076
Du, Yang, Hu, Sun, Zhang, Peng, Zhong, Huang, Kong: A long-term high-fat diet increases oxidative stress, mitochondrial damage and apoptosis in the inner ear of D-galactose-induced aging rats. in Hearing research 2012
Show all 4 references for ABIN1535076
Human Polyclonal NOX3 Primary Antibody for IF (p), IHC (p) - ABIN702595
Wakatsuki, Furuno, Ohshima, Araki: Oxidative stress-dependent phosphorylation activates ZNRF1 to induce neuronal/axonal degeneration. in The Journal of cell biology 2015
Together, these findings reveal that Nox2 (show CYBB Antibodies) is a Zn(2+)-regulated enzyme that mediates ZnD-induced oxidative stress and kidney hypertrophy. Understanding the specific mechanisms by which ZnD contributes to kidney damage may have an important impact on the treatment of chronic kidney disease.
Nox3 mutants and heterozygotes demonstrated a greater susceptibility to noise-induced hearing loss.
Although Nox3 overexpression revealed no apparent effect, depletion of Nox3 decreased the number of spermatogonial stem cells in both cultured spermatogonia and freshly isolated testis cells.
Microarray profiling on freshly isolated ECs had a genetic signature for microvascular heart ECs and identified Meox2 (show MEOX2 Antibodies)/Tcf15 (show TCF15 Antibodies) heterodimers as novel transcriptional determinants. This signature was similar in skeletal muscle and adipose tissue endothelium.
The miRNA family miR (show MLXIP Antibodies)-130/301/721 enhances induced pluripotent stem cells generation via repression of Meox2 (show MEOX2 Antibodies).
Mutations of Nox3 include retrovirus insertion, missense mutations, splice donor mutation, a splice acceptor mutation and premature translational termination.
palmitate-induced ROS (show ROS1 Antibodies) generation and that NOX3-derived ROS (show ROS1 Antibodies) may drive palmitate-induced hepatic insulin (show INS Antibodies) resistance through JNK (show MAPK8 Antibodies) and p38(MAPK (show MAPK14 Antibodies)) pathways.
an allelic series of mutations at the otoconia-deficient head tilt (het) locus, affecting the gene for NADPH oxidase 3 (Nox3), identifies Nox3 as a protein with a clear enzymatic function indispensable for otoconia morphogenesis
NOX3 is a relevant source of ROS (show ROS1 Antibodies) generation in the cochlear and vestibular systems and that NOX3-dependent ROS (show ROS1 Antibodies) generation might contribute to hearing loss and balance problems in response to ototoxic drugs.
Results demonstrate that Meox1 (show MEOX1 Antibodies) and Meox2 (show MEOX2 Antibodies) genes function together and upstream of several genetic hierarchies that are required for the development of somites.
In lung transplants, our study highlights a donor-recipient interaction of NOX3 and NFE2L2 (show NFE2L2 Antibodies) that increases the risk of PGD (show PGD Antibodies).
Reduced matrigel invasion was mediated by reduced ROS (show ROS1 Antibodies) levels coinciding with decreased expression of NADPH oxidase 2 (show CYBB Antibodies), 3, 4 and 5 involved in ROS (show ROS1 Antibodies) production.
Down-regulation of NOX3 using siRNA prevented TNF-alpha (show TNF Antibodies)-induced decrease of cellular glycogen (show GYS1 Antibodies).
Nox3 is regulated by NOXO1 (show NOXO1 Antibodies), p47phox (show NCF1 Antibodies), and p67phox (show NCF2 Antibodies)
Nox3 functions together with p22(phox (show CYBA Antibodies)) as an enzyme constitutively producing superoxide
Rac1 regulates both oxidases Nox1 (show NOX1 Antibodies) and Nox3 through the Nox activators
In conclusion, the results demonstrate that NOX3, a reactive oxygen species generating NADPH oxidase (show NOX1 Antibodies), plays an integral role in insulin (show INS Antibodies)-induced p42 (show EPB42 Antibodies)/44 Mitogen-activated protein kinase (show MAPK1 Antibodies) signal transmission and VEGF-A (show VEGFA Antibodies) production.
Roles for p22phox (show CYBA Antibodies) at several distinct points in the maturation and assembly of a functionally competent Nox3 in the plasma membrane.
Potential candidate genes in these regions that have been implicated in diabetic nephropathy and/or renal damage in models of hypertension include CYBA (show CYBA Antibodies) (or P22PHOX (show CYBA Antibodies)) (16q24), NOX1 (show NOX1 Antibodies) (10q22), and NOX3 (6q25.1-q26).
This gene encodes a member of the NOX family of NADPH oxidases. These enzymes have the capacity to generate superoxide and other reactive oxygen species (ROS) and transport electrons across the plasma membrane. The ROS generated by family members have been implicated in numerous biological functions including host defense, posttranlational processing of proteins, cellular signaling, regulation of gene expression, and cell differentiation. The protein encoded by this gene is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.
NADPH oxidase 3
, NADPH oxidase 3-like
, Cd200 antigen
, MRC OX-2 antigen
, OX-2 membrane glycoprotein
, cell surface protein (thymocyte antigen identified by monoclonal antibody MRC-OX2)
, homeobox protein MOX-2
, NADPH oxidase catalytic subunit-like 3
, gp91phox homolog 3
, mitogenic oxidase 2
, predicted NADPH oxidase-3