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NOX4 encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. Additionally we are shipping NADPH Oxidase 4 Antibodies (119) and NADPH Oxidase 4 Kits (16) and many more products for this protein.
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High expression of NOX4 is associated with metastasis in prostate cancer.
The angiogenic effect of TRAIL on human microvascular endothelial cell-1 cells i (show NOS3 Proteins)s downstream of fibroblast growth factor-2, involving NOX4 and nitric oxide signaling.
A deep understanding of Nox4 structure/function and mechanisms of regulation could lead both to the identification of new therapeutic targets and to the development of innovative strategies for appropriate osteoarthritis treatment. [review]
Expression of NOX4/p22(phox (show CYBA Proteins)) as well as ROS (show ROS1 Proteins) production is enhanced by IL-1beta (show IL1B Proteins). On the other hand, the use of NOX4 inhibitors decreased IL-1beta (show IL1B Proteins)-induced collagenase synthesis by chondrocytes.
Nox4 is a positive transcriptional regulator of cystathionine-gamma-lyase (show CTH Proteins) in endothelial cells.
An endogenous NOX4 forms macromolecular complexes with calnexin (show CANX Proteins), which are needed for the proper maturation, processing, and function of NOX4 in the endoplasmic reticulum.
IFNgamma induces oxidative stress, DNA damage and tumor cell senescence via TGFbeta/SMAD signaling-dependent induction of Nox4 and suppression of ANT2
Nox4 knockout (Nox4(-/-)) murine hematopoietic progenitor cells were refractory to FLT3ITD-mediated transformation in vitro
The reactive oxygen species-generating NADPH oxidase-4 (Nox4) is induced downstream of ATF4 (show ATF4 Proteins), binds to a PP1 (show PPA1 Proteins)-targeting subunit GADD34 (show PPP1R15A Proteins) at the endoplasmic reticulum, and inhibits PP1 (show PPA1 Proteins) activity to increase eIF2alpha (show EIF2A Proteins) phosphorylation and ATF4 (show ATF4 Proteins) levels.
H2O2-forming NOX4, unlike the superoxide-forming NOX1 (show NOX1 Proteins), can act as a negative modulator of inflammation and remodeling and convey atheroprotection.
Peroxide derived from superoxide generated by Nox4 appears to maintain a basal relaxation in bovine pulmonary arteries under normoxic conditions, which is removed under hypoxia leading to hypoxic pulmonary vasoconstriction.
proteasome inhibition completely prevented endoplasmic reticulum stress-induced increase in NADPH oxidase (show NOX1 Proteins) activity, as well as increases in Nox4 isoform and protein disulfide isomerase (show P4HB Proteins) mRNA expression
TRAIL can promote angiogenesis following hindlimb ischemia in vivo via NOX4/eNOS (show NOS3 Proteins)/nitric oxide signaling.
NOX4 may thus associate with mitochondrial complex I proteins, but in cardiac and renal mitochondria under basal conditions, expression is beyond our detection limits.
These results indicate that Ang-II (show AGT Proteins) induces cardiac fibroblast proliferation and migration in part via Nox4/ROS (show ROS1 Proteins)-dependent IL-18 (show IL18 Proteins) induction and MMP9 (show MMP9 Proteins) activation, and may involve AT1 (show SLC33A1 Proteins)/Nox4 physical association.
activated PKCzeta (show PRKCZ Proteins) phosphorylated p65 (show NFkBP65 Proteins) rel, which led to increased Nox4 synthesis
ERK1/2 plays an important role in TGF-beta1 (show TGFB1 Proteins)-induced mTOR (show FRAP1 Proteins) activation and translational regulation of Nox4 protein.
Intradermal administration of siHSP47-nanoparticles effectively reduced HSP47 (show SERPINH1 Proteins) protein expression in skin to normal level.
NOX1 (show NOX1 Proteins) and NOX4 signaling mediates the pathogenesis of liver fibrosis, including the direct activation of HSC (show FUT1 Proteins).
Nox4 maintains VEGF (show VEGFA Proteins) expression and prevents an increase in angiopoietin 1 (show ANGPT1 Proteins) expression, thereby contributing to angiogenesis in exercise. Nox4 does not influence developmental angiogenesis.
MRTF down-regulation/inhibition suppresses TGFbeta (show TGFB1 Proteins)/contact disruption-provoked Nox4 protein and mRNA expression, Nox4 promoter activation, and reactive oxygen species production.
Nox4 NADPH oxidase (show NOX1 Proteins) mediates oxidative stress and apoptosis caused by TNF-alpha (show TNF Proteins) in cerebral vascular endothelial cells.
Nox4 NADPH oxidase (show NOX1 Proteins)-derived reactive oxygen species also initiate a cell survival mechanism by increasing production of carbon monoxide by constitutive heme oxygenase-2 (show HMOX2 Proteins).
This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.
NADPH oxidase 4
, predicted NADPH oxidase-4
, kidney oxidase-1
, kidney superoxide-producing NADPH oxidase
, renal NAD(P)H-oxidase
, superoxide-generating NADPH oxidase 4