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NADPH Oxidase 4 Proteins (NOX4)

NOX4 encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. Additionally we are shipping NADPH Oxidase 4 Antibodies (137) and NADPH Oxidase 4 Kits (16) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NOX4 50507 Q9NPH5
NOX4 50490 Q9JHI8
NOX4 85431 Q924V1
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Top NADPH Oxidase 4 Proteins at antibodies-online.com

Showing 7 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Rat His-SUMO Tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Wheat germ Human Un-conjugated   2 μg Log in to see 11 to 12 Days
$426.92
Details

NOX4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,
Rat (Rattus)

More Proteins for NADPH Oxidase 4 (NOX4) Interaction Partners

Human NADPH Oxidase 4 (NOX4) interaction partners

  1. Data suggest that NOX4 and mitochondrial oxidative stress are mediators of cardiovascular disease in aging under hyperlipidemic conditions.

  2. Downregulation of smooth muscle Nox4 inhibits neointimal hyperplasia by suppressing TSP1 (show THBS1 Proteins).

  3. High expression of NOX4 is associated with metastasis in prostate cancer.

  4. The angiogenic effect of TRAIL on human microvascular endothelial cell-1 cells i (show NOS3 Proteins)s downstream of fibroblast growth factor-2, involving NOX4 and nitric oxide signaling.

  5. A deep understanding of Nox4 structure/function and mechanisms of regulation could lead both to the identification of new therapeutic targets and to the development of innovative strategies for appropriate osteoarthritis treatment. [review]

  6. Expression of NOX4/p22(phox (show CYBA Proteins)) as well as ROS (show ROS1 Proteins) production is enhanced by IL-1beta (show IL1B Proteins). On the other hand, the use of NOX4 inhibitors decreased IL-1beta (show IL1B Proteins)-induced collagenase synthesis by chondrocytes.

  7. Nox4 is a positive transcriptional regulator of cystathionine-gamma-lyase (show CTH Proteins) in endothelial cells.

  8. An endogenous NOX4 forms macromolecular complexes with calnexin (show CANX Proteins), which are needed for the proper maturation, processing, and function of NOX4 in the endoplasmic reticulum.

  9. IFNgamma induces oxidative stress, DNA damage and tumor cell senescence via TGFbeta/SMAD signaling-dependent induction of Nox4 and suppression of ANT2

  10. Nox4 knockout (Nox4(-/-)) murine hematopoietic progenitor cells were refractory to FLT3ITD-mediated transformation in vitro

Cow (Bovine) NADPH Oxidase 4 (NOX4) interaction partners

  1. Peroxide derived from superoxide generated by Nox4 appears to maintain a basal relaxation in bovine pulmonary arteries under normoxic conditions, which is removed under hypoxia leading to hypoxic pulmonary vasoconstriction.

Rabbit NADPH Oxidase 4 (NOX4) interaction partners

  1. proteasome inhibition completely prevented endoplasmic reticulum stress-induced increase in NADPH oxidase (show NOX1 Proteins) activity, as well as increases in Nox4 isoform and protein disulfide isomerase (show P4HB Proteins) mRNA expression

Mouse (Murine) NADPH Oxidase 4 (NOX4) interaction partners

  1. the reduction of ROS generation and NOX4 expression by EA preconditioning might be involved in BBB recovery. Therefore, EA may serve as a potential preventive strategy for patients at high risk of ischemic stroke.

  2. Deleterious effect of Nox4 expression in podocytes by promoting podocytopathy in association with albuminuria and extracellular matrix accumulation in experimental diabetes, emphasizes the role of NOX4 as a target for new renoprotective agents.

  3. Data suggest that NOX4 and mitochondrial oxidative stress are mediators of cardiovascular disease in aging under hyperlipidemic conditions.

  4. Downregulation of smooth muscle Nox4 inhibits neointimal hyperplasia by suppressing TSP1 (show GZMA Proteins).

  5. TRAIL can promote angiogenesis following hindlimb ischemia in vivo via NOX4/eNOS (show NOS3 Proteins)/nitric oxide signaling.

  6. NOX4 may thus associate with mitochondrial complex I proteins, but in cardiac and renal mitochondria under basal conditions, expression is beyond our detection limits.

  7. IFNgamma induces oxidative stress, DNA damage and tumor cell senescence via TGFbeta/SMAD signaling-dependent induction of Nox4 and suppression of ANT2

  8. These results indicate that Ang-II (show AGT Proteins) induces cardiac fibroblast proliferation and migration in part via Nox4/ROS (show ROS1 Proteins)-dependent IL-18 (show IL18 Proteins) induction and MMP9 (show MMP9 Proteins) activation, and may involve AT1 (show SLC33A1 Proteins)/Nox4 physical association.

  9. H2O2-forming NOX4, unlike the superoxide-forming NOX1 (show NOX1 Proteins), can act as a negative modulator of inflammation and remodeling and convey atheroprotection.

  10. activated PKCzeta (show PRKCZ Proteins) phosphorylated p65 (show NFkBP65 Proteins) rel, which led to increased Nox4 synthesis

Pig (Porcine) NADPH Oxidase 4 (NOX4) interaction partners

  1. MRTF down-regulation/inhibition suppresses TGFbeta (show TGFB1 Proteins)/contact disruption-provoked Nox4 protein and mRNA expression, Nox4 promoter activation, and reactive oxygen species production.

  2. Nox4 NADPH oxidase (show NOX1 Proteins) mediates oxidative stress and apoptosis caused by TNF-alpha (show TNF Proteins) in cerebral vascular endothelial cells.

  3. Nox4 NADPH oxidase (show NOX1 Proteins)-derived reactive oxygen species also initiate a cell survival mechanism by increasing production of carbon monoxide by constitutive heme oxygenase-2 (show HMOX2 Proteins).

NADPH Oxidase 4 (NOX4) Protein Profile

Protein Summary

This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with NADPH Oxidase 4 Proteins (NOX4)

  • NADPH oxidase 4 (NOX4)
  • NADPH oxidase 4 (nox4)
  • NADPH oxidase 4 (PTRG_09562)
  • NADPH oxidase 4 (Nox4)
  • AI648021 protein
  • KOX protein
  • KOX-1 protein
  • NOX4 protein
  • RENOX protein

Protein level used designations for NADPH Oxidase 4 Proteins (NOX4)

NADPH oxidase 4 , predicted NADPH oxidase-4 , kidney oxidase-1 , kidney superoxide-producing NADPH oxidase , renal NAD(P)H-oxidase , KOX-1 , superoxide-generating NADPH oxidase 4 , kox-1

GENE ID SPECIES
419012 Gallus gallus
619226 Ciona intestinalis
705931 Macaca mulatta
735636 Pan troglodytes
6347852 Pyrenophora tritici-repentis Pt-1C-BFP
50507 Homo sapiens
378474 Bos taurus
100034665 Ovis aries
100339697 Oryctolagus cuniculus
50490 Mus musculus
85431 Rattus norvegicus
100523323 Sus scrofa
485144 Canis lupus familiaris
100171782 Pongo abelii
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