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NDC80 encodes a component of the NDC80 kinetochore complex. Additionally we are shipping NDC80 Proteins (5) and NDC80 Kits (1) and many more products for this protein.
Showing 10 out of 98 products:
Hamster Monoclonal NDC80 Primary Antibody for FACS, ICC - ABIN151804
Chen, Riley, Chen, Lee: HEC, a novel nuclear protein rich in leucine heptad repeats specifically involved in mitosis. in Molecular and cellular biology 1997
Show all 42 references for ABIN151804
Human Monoclonal NDC80 Primary Antibody for WB - ABIN394739
Olson, Wang, Pankratz, Fredericksen, Vachon, Vierkant, Cerhan, Couch: Centrosome-related genes, genetic variation, and risk of breast cancer. in Breast cancer research and treatment 2010
Show all 5 references for ABIN394739
Human Monoclonal NDC80 Primary Antibody for ELISA, WB - ABIN564521
Scott, Nogueira, Heffernan, van Doorn, Dhakal, Hanna, Min, Jaskelioff, Xiao, Wu, Cameron, Perry, Zeid, Feinberg, Kim, Vande Woude, Granter, Bosenberg, Chu, DePinho, Rimm, Chin: Proinvasion metastasis drivers in early-stage melanoma are oncogenes. in Cancer cell 2011
kinetochores movement depends on SPC105R, can occur in the absence of NDC80, and is antagonized by plus-end directed forces from the CENP-E (show CENPE Antibodies) motor.
Hec1-dependent cyclin B2 (show CCNB2 Antibodies) stabilization during early metaphase is important for early-stage spindle assembly.
Disruption of Ndc80 function by either siRNA injection or antibody injection resulted in severe chromosome misalignment, spindle disruption, and precocious polar body extrusion.
overexpression of Hec1 results in mitotic checkpoint (show BUB3 Antibodies) hyperactivation that leads to aneuploidy sufficient to generate tumors
Expression of NDC80 in colon cancer cells and tissues was higher than that in controls. NDC80 promotes the proliferation and metastasis of colon cancer cells.
Ndc80 complex bound to microtubules binds every tubulin (show TUBB Antibodies) monomer along the microtubule protofilament.
we conclude that Hec1 is consistently overexpressed in human PCa (show FLVCR1 Antibodies) and Hec1 is closely linked with human PCa (show FLVCR1 Antibodies) progression through the meditator LncRNA BX647187
Independent molecular binding events to microtubules (MTs (show TIMM8A Antibodies)) by individual NDC80 complexes, rather than their structured oligomers, regulate the dynamics and stability of kinetochore-MT attachments in dividing cells.
The Ndc80 complex binds straight microtubules by recognizing the dimeric interface of tubulin (show TUBB Antibodies).
Overproduction of Ndc80 in cancer cells may unfavourably absorb protein interactors through the internal loop domain and lead to a change in the equilibrium of microtubule-associated proteins. [Review]
N-terminus-modified Hec1 suppresses tumour growth by interfering with kinetochore-microtubule dynamics
Mechanisms of mitosis-specific assembly of the checkpoint platform Knl1 (show CASC5 Antibodies)/MIS12 (show MIS12 Antibodies)/NDC80 at human kinetochores.
Certain clinical subtypes of breast cancer more likely to respond to Hec1-targeted therapy were identified and these subtypes are the ones associated with poor prognosis.
Hec1 is critical in maintaining the in vitro and in vivo growth of gastric cancer cells; elevated Hec1 levels may occur at the early stage of gastric tumorigenesis
mature attachment via the Ndc80 complex is essential for metaphase alignment and anaphase A
This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation.
kinetochore associated 2
, NDC80 homolog, kinetochore complex component (S. cerevisiae)
, NDC80 homolog, kinetochore complex component
, kinetochore protein NDC80 homolog
, kinetochore protein Ndc80
, Kinetochore protein NDC80 homolog
, highly expressed in cancer, rich in leucine heptad repeats
, kinetochore protein Hec1
, kinetochore-associated protein 2
, HEC (highly expressed in cancer)
, NDC80 kinetochore complex component homolog
, highly expressed in cancer protein
, retinoblastoma-associated protein HEC
, kinetochore spindle checkpoint protein Ndc80