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NELL1 encodes a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats. Additionally we are shipping NEL-Like 1 (Chicken) Proteins (7) and NEL-Like 1 (Chicken) Kits (5) and many more products for this protein.
Showing 10 out of 27 products:
Human Polyclonal NELL1 Primary Antibody for WB - ABIN518278
Hasebe, Tashima, Ide, Iijima, Yoshimoto, Ting, Kuroda, Niimi: Efficient production and characterization of recombinant human NELL1 protein in human embryonic kidney 293-F cells. in Molecular biotechnology 2012
Show all 2 references for ABIN518278
Human Monoclonal NELL1 Primary Antibody for IF, IP - ABIN561954
Franke, Hampe, Rosenstiel, Becker, Wagner, Häsler, Little, Huse, Ruether, Balschun, Wittig, Elsharawy, Mayr, Albrecht, Prescott, Onnie, Fournier, Keith, Radelof, Platzer, Mathew, Stoll, Krawczak et al.: Systematic association mapping identifies NELL1 as a novel IBD disease gene. ... in PLoS ONE 2007
Nell-1-haploinsufficient mice (show WNT2 Antibodies)have normal s (show CTNNB1 Antibodies)keletal development but undergo age-related osteoporosis, characterized by a reduction in osteoblast:osteoclast ratio and increased bone fragility.
These results suggest that an oligomerization-induced conformational change in the C-terminal region of NELL1 is important for the efficient mediation of cell adhesion and spreading by NELL1.
Nell-1 might play a role in ameloblast and odontoblast differentiation, secretion and mineralization of the extracellular enamel matrix, molar crown morphogenesis, as well as root formation during the entire development period.
NELL-1 protein promotes cell adhesion in ST2 cells.
The C-terminal region of NELL1 mediates osteoblastic cell adhesion through integrin alpha3beta1
data suggest Nell-1 is important growth factor for regulation of osteochondral differentiation regulating both Runx2 (show RUNX2 Antibodies) and Sox9 (show SOX9 Antibodies) expression in calvarium. Nell-1 is required for normal craniofacial membranous and endochondral skeletal development.
These studies suggest that Nell-1 is a potent anti-adipogenic agent. Moreover, Nell-1 signaling may inhibit adipogenic differentiation via a Hedgehog (show SHH Antibodies) dependent mechanism.
Nfatc2 (show NFAT1 Antibodies) likely plays an important role in Nell-1-mediated osteochondral differentiation in vitro and in vivo.
Nell-1 supports continued osteoblastic differentiation and function in osteoblastic lineage cells during calvarial development. Nell-1 is a key functional, downstream mediator of Runx2 (show RUNX2 Antibodies) osteogenic activity.
A recessive, neonatal-lethal point mutation in the Nell1 gene causes cranial and skeletal defects.
establish the feasibility of combining NELL-1 with BMP2 (show BMP2 Antibodies) to improve clinical bone regeneration and provide mechanistic insight into canonical Wnt (show WNT2 Antibodies) pathway activity during NELL-1 and BMP2 (show BMP2 Antibodies) osteogenesis
Data suggest that TSPN (N-terminal thrombospondin-1-like (show THBS1 Antibodies)) domain of NELL1 exhibits major heparin-binding sites which may be involved in interaction of NELL1 with cell surface heparan sulfate proteoglycans.
NELL-1 signaling activates Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling.
We also detected lower relative expression of Nell-1 by real-time PCR. Furthermore, immunohistochemical analyses revealed that Nell-1 staining was less intense in cancer tissue relative to normal tissue and that the tumor cells had spread to the muscle
CpG islands in the NELL1 and NELL2 (show NELL2 Antibodies) promoters are hypermethylated in renal cell carcinoma.NELL1 and NELL2 (show NELL2 Antibodies) protein expression is downregulated in clear cell renal carcinoma (show TSC2 Antibodies).
NELL-1 demonstrates diffuse and reliable expression in benign but not malignant bone-forming skeletal tumors
NELL1 overexpression greatly enhanced the osteogenic differentiation and mineral synthesis of iPSC-MSCs on RGD-grafted CPC scaffold for the first time.
Two single-nucleotide polymorphisms of the NELL1 gene may represent a novel mechanism underlying hydrochlorothiazide-induced adverse metabolic effects (meta-analysis).
NELL1 is able to promote the osteogenic differentiation of periodontal ligament stem cells, which may be related to the downregulation of Msx2 expression.
Activation of the JNK (show MAPK8 Antibodies) pathway is necessary to mediate terminal osteogenic different-iation of Saos-2 osteosarcoma cells by rhNELL-1.
This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. Two transcript variants encoding different isoforms have been found for this gene.
NEL-like protein 1
, protein kinase C-binding protein NELL1
, NELL-1 protein short isoform
, nel-related protein 1
, neural epidermal growth factor-like 1