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The protein encoded by NEK6 is a kinase required for progression through the metaphase portion of mitosis. Additionally we are shipping NEK6 Antibodies (70) and many more products for this protein.
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NEK6 is overexpressed in various human cancer tissues, and ectopic expression of NEK6 increases tumor promoter-induced transformation of JB6 Cl41 mouse epidermal cells.
During early embryogenesis nek6 is highly expressed in primary giant trophoblast cells. Later in embryogenesis, nek6 is found in ventricular and sub-ventricular regions.
NEK6 (show NEK5 Proteins) forms heterodimers with NEK4 and NEK5 to regulate cortical microtubule organization possibly through the phosphorylation of beta-tubulins.
Overexpression of AURKA (show AURKA Proteins) and NEK6 genes was significantly more pronounced in Ulcerative colitis patients with more extensive colon involvement
NEK6 suppresses the cell growth arrest induced by TGFbeta (show TGFB1 Proteins). Mechanically, NEK6 blocks nuclear translocation of Smad4 (show SMAD4 Proteins), which is essential for TGFbeta (show TGFB1 Proteins) function.
Nek6 is also a critical signaling molecule that helps prevent cardiac hypertrophy and inhibits the Akt (show AKT1 Proteins) signaling pathway.
Nek6 facilitates association of Hsp72 (show HSPA1A Proteins) with the mitotic spindle, where it promotes stable K-fiber assembly through recruitment of the ch-TOG-TACC3 (show TACC3 Proteins) complex.
Nek6 plays an important role in the premature senescence of cancer cells.
High Nek6 is associated with hepatic cell cancer.
Nek9 (show NEK9 Proteins) is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5 (show KIF11 Proteins).
These results suggest that the increased expression of Nek6 renders cancer cells resistant to premature senescence, and targeting Nek6 could be an efficient strategy for cancer treatment.
DYNLL/LC8 (show DYNLL1 Proteins) protein controls signal transduction through the Nek9 (show NEK9 Proteins)/Nek6 signaling module by regulating Nek6 binding to Nek9 (show NEK9 Proteins).
NEK6 expression is downregulated in both replicative and premature senscence of human cnacer cells, and the inhibition of Nek6 activity is important for the onset of cellular senescence.
The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene.
NIMA-related expressed kinase 6
, never in mitosis A-related kinase 6
, nimA-related protein kinase 6
, serine/threonine-protein kinase Nek6
, putative serine-threonine protein kinase
, NIMA (never in mitosis gene a)-related kinase 6
, protein kinase SID6-1512
, NIMA (never in mitosis gene a)-related expressed kinase 6