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NLR Family, Pyrin Domain Containing 12 Proteins (NLRP12)

NLRP12 encodes a member of the CATERPILLER family of cytoplasmic proteins. Additionally we are shipping NLRP12 Antibodies (105) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat NLRP12 NLRP12 292541  
NLRP12 91662 P59046
NLRP12 378425  
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Top NLRP12 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

NLRP12 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for NLR Family, Pyrin Domain Containing 12 (NLRP12) Interaction Partners

Human NLR Family, Pyrin Domain Containing 12 (NLRP12) interaction partners

  1. This process involved the upregulation of NLRP12.

  2. NLRX1, NLRP12 and NLRC3 negatively modulate the host immune response following virus exposure. (Review)

  3. Variants of NLRP12 were associated with common variable immunodeficiency.

  4. NLRP12/NLRP3 (show NLRP3 Proteins)-dependent activation of caspase-1 (show CASP1 Proteins) is likely to be a key event in mediating systemic production of IL-1beta (show IL1B Proteins) and hypersensitivity to secondary bacterial infection during malaria.

  5. The genetics, expression and roles of NLRP12 in inflammatory signaling, host defense, and carcinogenes (show GUSB Proteins)is are reviewed. Review.

  6. This study suggested that NLRP12 mutations might account for a small fraction of common variable immunodeficiency patients with severe auto-inflammatory complications.

  7. We will focus on NLRP6 and NLRP12.

  8. Letter: NLRP12 mutations associated with familial cold autoinflammatory syndrome 2 in Italian patients.

  9. Even with a variable range of associated manifestations, the extreme sensitivity to cold represents the main clinical hallmark in an individual carrying the p.D294E mutation of the NLRP12 gene.

  10. The authors report the first in vitro confirmed non-homotypic interaction between NLRP12 pyrin (show MEFV Proteins) domain and the pro-apoptotic protein Fas-associated factor 1 (FAF-1 (show FAF1 Proteins)), which links the innate immune system to apoptotic signaling.

Mouse (Murine) NLR Family, Pyrin Domain Containing 12 (NLRP12) interaction partners

  1. Nlrp12 deficiency caused increased neutrophil migration towards the chemokine (show CCL1 Proteins) CXCL1 and the neutrophil parasite Leishmania major, revealing NLRP12 as a negative regulator of directed neutrophil migration under these conditions.

  2. modulation of NLRP12 levels controls alternative NF-kappaB (show NFKB1 Proteins) signaling in OC precursors, altering bone homeostasis and osteolytic responses

  3. The absence of Nlrp12 results in an increased inflammatory response

  4. NLRP12 is an intrinsic negative regulator of T-cell-mediated immunity via altered NF-kappaB (show NFKB1 Proteins) regulation and IL-4 (show IL4 Proteins) production as key mediators of NLRP12-associated disease.

  5. NLRP12/NLRP3 (show NLRP3 Proteins)-dependent activation of caspase-1 (show CASP1 Proteins) is likely to be a key event in mediating systemic production of IL-1beta (show IL1B Proteins) and hypersensitivity to secondary bacterial infection during malaria.

  6. The role of NLRP12 in NF-KB signaling, bacterial infections, colitis, colorectal tumorigenesis and gut (show GUSB Proteins) homeostasis is studied in knockout mice. Review.

  7. NLRP12-deficient mice are highly resistant to S. typhimurium infection, which highlights the signaling pathway defined by NLRP12-mediated dampening of host immune defenses that could be exploited by S. typhimurium to persist and survive in the host

  8. NLRP12 does not significantly contribute to the in vivo host innate immune response to LPS (show TLR4 Proteins) stimulation, Klebsiella pneumonia infection or Mycobacterium tuberculosis

  9. NLRP12 negatively regulated ERK (show EPHB2 Proteins) and AKT (show AKT1 Proteins) signaling pathways in affected tumor tissues.

  10. NLRP12 does not play a vital role in regulating Th2 driven airway inflammation using common model systems that are physiologically relevant to human disease.

NLRP12 Protein Profile

Protein Summary

This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with NLRP12

  • NLR family, pyrin domain containing 12 (Nlrp12)
  • NLR family, pyrin domain containing 12 (NLRP12)
  • CLR19.3 protein
  • FCAS2 protein
  • NALP12 protein
  • PAN6 protein
  • PYPAF7 protein
  • RNO protein
  • RNO2 protein

Protein level used designations for NLRP12

NACHT, leucine rich repeat and PYD containing 12 , NLR family, pyrin domain containing 12 , PYRIN-containing APAF1-like protein 7 , NACHT, LRR and PYD domains-containing protein 12 , NLR family, pyrin domain containing 12, isoform 2 , monarch 1 , nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12 , regulated by nitric oxide , NACHT, LRR and PYD containing protein 12 , monarch-1

GENE ID SPECIES
292541 Rattus norvegicus
469002 Pan troglodytes
522018 Bos taurus
100018508 Monodelphis domestica
100063024 Equus caballus
100137561 Papio anubis
100352122 Oryctolagus cuniculus
100402104 Callithrix jacchus
100465031 Ailuropoda melanoleuca
100523066 Sus scrofa
100600667 Nomascus leucogenys
91662 Homo sapiens
378425 Mus musculus
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