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NLRX1 encodes a member of the NLR family. Additionally we are shipping and NLRX1 Kits (1) and many more products for this protein.
Showing 10 out of 57 products:
Human Polyclonal NLRX1 Primary Antibody for ELISA, WB - ABIN4340142
Tattoli, Carneiro, Jéhanno, Magalhaes, Shu, Philpott, Arnoult, Girardin: NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-kappaB and JNK pathways by inducing reactive oxygen species production. in EMBO reports 2008
The data suggests that NLRX1 plays a positive role in Kaposi's sarcoma-associated herpesvirus (KSHV) lytic replication by suppressing the IFNbeta response during the process of KSHV reactivation, which might serve as a potential target for restricting KSHV replication and transmission.
we identify a novel signaling hub centering on the NLRX1 TUFM (show Tufm Antibodies) protein complex, promoting autophagic flux. Defects in the expression of either NLRX1 or TUFM (show Tufm Antibodies) result in compromised autophagy when treated with EGFR (show EGFR Antibodies) inhibitors.These findings expand our understanding of the components involved in head and neck squamous cell carcinoma autophagy machinery that responds to EGFR (show EGFR Antibodies) inhibitors.
findings suggest that NLRX1 may function as a cardiac-protective molecule in myocardial ischemic injury by repressing inflammation and apoptosis
NLRX1, NLRP12 (show NLRP12 Antibodies) and NLRC3 (show NLRC3 Antibodies) negatively modulate the host immune response following virus exposure. (Review)
NLRX1 acts as a potential tumor suppressor by regulating the TNF-alpha (show TNF Antibodies) induced cell death and metabolism.
These data support a model in which CS-dependent NLRX1 inhibition facilitates MAVS (show MAVS Antibodies)/RHL (show DDX46 Antibodies) activation and subsequent inflammation, remodeling, protease, cell death, and inflammasome responses.
Together, these results suggest a novel mechanism for rhinovirus-induced epithelial barrier disruption involving NLRX-1 and mitochondrial reactive oxygen species generation.
NLRX1 and TUFM (show Tufm Antibodies) work in concert to reduce cytokine response and augment autophagy.
Results showed that missense mutations in transmembrane protein 2 p.Ser1254Asn, interferon alpha 2 p.Ala120Thr, its regulator NLR family member X1 p.Arg707Cys, and complement component 2 p.Glu318Asp were associated with chronic hepatitis B.
Post-transcriptional inhibition of luciferase reporter assays by the Nod-like receptor proteins NLRX1 and NLRC3 (show NLRC3 Antibodies).
this in vitro studies show that NLRX1-deficient T cells have a greater ability to differentiate into an inflammatory phenotype and possess greater proliferation rates
NLRX1 sequesters the DNA-sensing adaptor STING from interaction with TBK1 (show TBK1 Antibodies), which is a requisite for IFN-1 induction in response to viral DNA.
NLRX1 diminishes Tumor Necrosis Factor-alpha (show TNF Antibodies)-induced activation of both Akt (show AKT1 Antibodies)- and NF-kappaB (show NFKB1 Antibodies)-dependent pathways. Since Akt (show AKT1 Antibodies) was shown to be essential for Tumor Necrosis Factor-alpha (show TNF Antibodies)-mediated activation of NF-kappaB (show NFKB1 Antibodies) it is likely that the primary effect of NLRX1 is at the level of C-Akt (show AKT1 Antibodies) proein signaling.
NLRX1 attenuated Apc (show APC Antibodies)(min/+) colon tumorigenesis, cellular proliferation, NF-KappaB (show NFKB1 Antibodies), mitogen-activated protein kinase (show MAPK1 Antibodies), signal transducer and activator of transcription 3 (show STAT3 Antibodies) activation, and interleukin 6 (show IL6 Antibodies) levels.
NLRX1 may relate to hair cell maturity, hearing formation and maintenance, and promote hair cell apoptosis through JNK (show MAPK8 Antibodies) pathway
The regulatory role of NLRX1 in mechanisms of host tolerance employed by macrophages to respond to Helicobacter pylori infection.NLRX1 modulates innate immune responses to Helicobacter pylori infection.
Nlrx1 may play an important role in neurodegenerative diseases, where necrosis is a prominent factor.
The unique capacity of NLRX1 to regulate the cellular sensitivity toward intrinsic versus extrinsic apoptotic signals suggests a critical role for this protein in numerous physiological processes and pathological conditions.
NLRX1 enhances macrophage antiviral immunity by interacting with influenza virus PB1 (show GPR97 Antibodies)-F2 protein, as well as preventing mitochondrial-induced apoptosis
This gene encodes a member of the NLR family. Alternative splicing has been observed at this gene locus and two transcript variants, encoding distinct isoforms, have been identified.
NLR family member X1
, NLR family, X1
, NOD-like receptor X1
, caterpiller protein 11.3
, nucleotide-binding oligomerization domain protein 26
, nucleotide-binding oligomerization domain protein 5
, nucleotide-binding oligomerization domain protein 9
, nucleotide-binding oligomerization domain, leucine rich repeat containing X1
, nucleotide-binding domain and leucine-rich repeat containing