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anti-Nascent Polypeptide Associated Complex alpha 1 (NACa1) Antibodies

The protein encoded by NACa1 associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). Additionally we are shipping Nascent Polypeptide Associated Complex alpha 1 Proteins (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NACa1 17938 P70670,Q60817
NACa1 4666 Q13765
NACa1 288770  
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Top anti-Nascent Polypeptide Associated Complex alpha 1 Antibodies at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB Human Liver (formalin-fixed, paraffin-embedded) stained with NACA antibody ABIN337196 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 8 to 10 Days
$595.83
Details
Human Mouse Un-conjugated IF, WB Western Blot analysis of NACA expression in transfected 293T cell line by NACA MaxPab polyclonal antibody.Lane 1: NACA transfected lysate(23.65 KDa).Lane 2: Non-transfected lysate. Immunofluorescence of purified MaxPab antibody to NACA on HeLa cell. [antibody concentration 10 ug/ml] 50 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated ELISA, IHC   100 μL Log in to see 14 Days
$201.19
Details
Human Rabbit Un-conjugated IHC, ELISA   100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA   100 μL Log in to see 8 to 10 Days
$478.50
Details
Human Rabbit Un-conjugated WB   100 μg Log in to see 11 to 16 Days
$595.57
Details
Human Mouse Un-conjugated IF, WB   50 μg Log in to see 11 to 16 Days
$553.14
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 9 to 19 Days
$448.47
Details

NACa1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Mouse (Murine) , ,


Human , ,
,

Rat (Rattus) , ,


Top referenced anti-Nascent Polypeptide Associated Complex alpha 1 Antibodies

  1. Human Polyclonal NACa1 Primary Antibody for IF, WB - ABIN518179 : Puigmulé, López-Hellin, Suñé, Tornavaca, Camaño, Tejedor, Meseguer: Differential proteomic analysis of cyclosporine A-induced toxicity in renal proximal tubule cells. in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2009 (PubMed)

More Antibodies against Nascent Polypeptide Associated Complex alpha 1 Interaction Partners

Mouse (Murine) Nascent Polypeptide Associated Complex alpha 1 (NACa1) interaction partners

  1. the skNAC-Smyd1 (show SMYD1 Antibodies) complex is involved in transcriptional regulation both via the control of histone methylation and histone (de)acetylation.

  2. skNAC binds to the E3 SUMO ligase mammalian Mms21/Nse2 (show NSMCE2 Antibodies) and that knockdown of Nse2 (show NSMCE2 Antibodies) expression inhibits specific aspects of myogenic differentiation, accompanied by a partial blockade of the nuclear-to-cytoplasmic translocation of the skNAC-Smyd1 (show SMYD1 Antibodies) complex

  3. depletion of alphaNAC in multiple types of cancer cells induce typical apoptotic cell death. This anti-apoptotic function is mediated by the FADD/c-Jun N-terminal kinase pathway.

  4. We propose that maximal transcriptional repression by FIAT (show TXLNG Antibodies) requires its interaction with SUMOylated, HDAC2 (show HDAC2 Antibodies)-interacting aNAC (show NACa2 Antibodies)

  5. Altered gene dosages for Galphas (show GNAS Antibodies) and alpha- NAC in compound heterozygous mice result in reduced bone mass, increased numbers of osteocytes, and enhanced expression of Sost (show SOST Antibodies).

  6. The bone phenotype of compound Naca(+/-); Fiat (show TXLNG Antibodies)(+/-) heterozygotes confirms that FIAT (show TXLNG Antibodies) and alphaNAC are part of a common genetic pathway and support a role for the FIAT (show TXLNG Antibodies)/alphaNAC interaction in normal bone physiology.

  7. data suggest that skNAC controls myoblast migration and sarcomere architecture in a calpain-dependent manner

  8. nascent polypeptide associated complex regulates specific aspects of myogenesis.

  9. The muscle-specific (show EIF3K Antibodies) transcription factor skNAC is the major binding partner for Smyd1 (show SMYD1 Antibodies) in the developing heart.

  10. Inhibition of alpha NAC nuclear translocation results in an osteopenic phenotype caused by reduced expression of osteocalcin (show BGLAP Antibodies) and type I collagen, accelerated mineralization, and immature woven-bone formation.

Zebrafish Nascent Polypeptide Associated Complex alpha 1 (NACa1) interaction partners

  1. Results demonstrate that skNAC plays a vital role in myofibril assembly and function during muscle cell differentiation.

Human Nascent Polypeptide Associated Complex alpha 1 (NACa1) interaction partners

  1. depletion of alphaNAC in multiple types of cancer cells induce typical apoptotic cell death. This anti-apoptotic function is mediated by the FADD/c-Jun N-terminal kinase pathway.

  2. Low NACA expression is associated with rhabdomyosarcoma.

  3. [review] First evidence of a functional interaction between ATF4 (show ATF4 Antibodies), FIAT (factor-inhibiting ATF4-mediated transcription (show TXLNG Antibodies)) and alphaNAC (nascent polypeptide-associated complex and coactivator alpha).

  4. NACA gene expression is decreased in both classic and follicular variants of papillary thyroid carcinoma.

  5. identified a region in the NAC (show NLRP1 Antibodies) domain of the human NAC alpha-subunit (show POLG Antibodies) as a new nucleic acid-binding region, which is blocked from binding nucleic acids in the heterodimeric complex by a helix region in the beta-subunit (show POLG Antibodies)

  6. Human brain nascent polypeptide-associated complex alpha subunit is decreased in patients with Alzheimer' s disease and Down syndrome.

  7. a novel isoform of alpha-nascent polypeptide-associated complex as IgE-defined autoantigen

  8. virtual Northern blots to analyze expression of NACA and ANX2 (show ANXA2 Antibodies) in progenitor cultures of nine children with Juvenile myelomonocytic leukemia and five healthy individuals

  9. Altogether, these results characterize NACA as a new factor involved in the positive regulation of human erythroid-cell differentiation.

  10. Alpha NAC downregulation in hypoxic cells or NAC (show NLRP1 Antibodies) ablation by NAC (show NLRP1 Antibodies) short-interfering RNA (siRNA) leads to the initiation of ER stress responses, which results in caspase (show CASP3 Antibodies)-dependent apoptosis.

Nascent Polypeptide Associated Complex alpha 1 (NACa1) Antigen Profile

Protein Summary

The protein encoded by this gene associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). NAC binds to nascent proteins as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. However, nascent proteins with an exposed signal peptide will not be bound by the encoded protein, enabling them to bind the SRP and enter the secretory pathway. This protein has been determined to be an IgE autoantigen in atopic dermatitis patients. Several transcript variants encoding two different isoforms have been found for this gene.

Gene names and symbols associated with NACa1

  • nascent polypeptide-associated complex alpha polypeptide (Naca) antibody
  • nascent polypeptide-associated complex alpha polypeptide (naca) antibody
  • nascent polypeptide-associated complex alpha subunit (NACA) antibody
  • nascent polypeptide-associated complex alpha subunit (Naca) antibody
  • AL022831 antibody
  • AL024382 antibody
  • Gm1878 antibody
  • ik:tdsubc_2b5 antibody
  • mKIAA0363 antibody
  • NACA1 antibody
  • nkn antibody
  • skNAC antibody
  • tdsubc_2b5 antibody
  • xx:tdsubc_2b5 antibody

Protein level used designations for NACa1

alpha-NAC, muscle-specific form , alpha-NAC/1.9.2 , nascent polypeptide-associated complex alpha subunit , nascent polypeptide-associated complex subunit alpha , nascent polypeptide-associated complex subunit alpha, muscle-specific form , NAC-alpha , alpha-NAC , no knack , sknac , nascent-polypeptide-associated complex alpha polypeptide

GENE ID SPECIES
17938 Mus musculus
195823 Danio rerio
4666 Homo sapiens
513312 Bos taurus
288770 Rattus norvegicus
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