NACA antibody (N-Term)

Catalog No. ABIN6263507

This Rabbit Polyclonal antibody specifically detects NACA in WB. It exhibits reactivity toward Human.

Quick Overview for NACA antibody (N-Term) (ABIN6263507)

Target: NACA (NACa1) (Nascent Polypeptide Associated Complex alpha 1 (NACa1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NACA antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-NACA Antibody

Binding Specificity: N-Term

Purpose: NACA Antibody

Specificity: NACA Antibody detects endogenous levels of total NACA.

Predicted Reactivity: Pig,Bovine,Sheep,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human NACA, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for NACA

Target: NACA (NACa1) (Nascent Polypeptide Associated Complex alpha 1 (NACa1))

Alternative Name: NACA

Background:

Description: Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters.

Gene: NACA

Molecular Weight: 24kDa

Gene ID: 4666

UniProt: Q13765

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development