NACA antibody (N-Term)

Catalog No. ABIN6263507

Product Details anti-NACA Antibody

Target: NACA (NACa1) (Nascent Polypeptide Associated Complex alpha 1 (NACa1))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NACA antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: NACA Antibody detects endogenous levels of total NACA.

Predicted Reactivity: Pig,Bovine,Sheep,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human NACA, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for NACA

Target: NACA (NACa1) (Nascent Polypeptide Associated Complex alpha 1 (NACa1))

Alternative Name: NACA (NACa1 Products)

Synonyms: AL022831 antibody, AL024382 antibody, Gm1878 antibody, mKIAA0363 antibody, skNAC antibody, ik:tdsubc_2b5 antibody, nkn antibody, tdsubc_2b5 antibody, xx:tdsubc_2b5 antibody, NACA1 antibody, nascent polypeptide-associated complex alpha polypeptide antibody, nascent polypeptide-associated complex alpha subunit antibody, Naca antibody, naca antibody, NACA antibody

Background:

Description: Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters.

Gene: NACA

Molecular Weight: 24kDa

Gene ID: 4666

UniProt: Q13765

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development