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NPR2 encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Additionally we are shipping NPR2 Proteins (37) and NPR2 Kits (18) and many more products for this protein.
Showing 10 out of 77 products:
Human Polyclonal NPR2 Primary Antibody for WB - ABIN191700
Küthe, Reinecke, Uckert, Becker, David, Heitland, Stief, Forssmann, Mägert: Expression of guanylyl cyclase B in the human corpus cavernosum penis and the possible involvement of its ligand C-type natriuretic polypeptide in the induction of penile erection. in The Journal of urology 2003
Human Polyclonal NPR2 Primary Antibody for IF (p), IHC (p) - ABIN679778
Li, Tang, Cai, Qiu, Lin, Zhu, Owusu, Guo: CNP signal pathway up-regulated in rectum of depressed rats and the interventional effect of Xiaoyaosan. in World journal of gastroenterology : WJG 2015
Human Polyclonal NPR2 Primary Antibody for IHC (fro), WB - ABIN191698
Hirsch, Skutta, Schlatter: Signaling and distribution of NPR-Bi, the human splice form of the natriuretic peptide receptor type B. in American journal of physiology. Renal physiology 2003
NPR2 (show NPRL2 Antibodies) is involved in FSH (show BRD2 Antibodies)-mediated oocyte meiotic resumption, and this process is associated with the EGFR (show EGFR Antibodies) and MAPK3 (show MAPK3 Antibodies)/1 signaling pathways.
NPR2 (show NPRL2 Antibodies) dephosphorylation in the mural granulosa cells is essential for the normal progression of meiosis in response to LH and EGF receptor (show EGFR Antibodies) activation.
Npr2 (show NPRL2 Antibodies) is necessary for the precise spatial organization typical of central auditory circuits, but signals are still transmitted with normal timing, and that mutant mice can hear even with these deficits.
Npr2 (show NPRL2 Antibodies) is expressed in hard calluses of wild-type mice, suggesting a possible role of CNP (show CNP Antibodies) signaling in fracture repair, especially in bone remodeling stage.
Data, including data from mutant mice strain Npr2 (show NPRL2 Antibodies)(slw/slw), suggest that Npr2 (show NPRL2 Antibodies) is critical for fertility but role of Npr2 (show NPRL2 Antibodies) may be more involved in penile function rather than involved in spermatogenesis.
These findings demonstrate that pNPPB may be used as a probe to identify the essential amino acid sequences for activation of NPR2 (show NPRL2 Antibodies).
GATA2 (show GATA2 Antibodies) and Lmo2 (show LMO2 Antibodies) cooperatively regulate VEGF (show VEGFA Antibodies)-induced angiogenesis and lymphangiogenesis via NRP2 (show NRP2 Antibodies).
Data suggest that epidermal growth factor (Egf)/Egf (show EGF Antibodies) receptor (show EGFR Antibodies) signaling in cumulus cells (CC) down-regulates Npr2 (show NPRL2 Antibodies), decreases cGMP, elevates calcium, and induces meiotic resumption/oogenesis in cultured CC-oocyte complexes (in induced meiotic arrest).
CNP (show CNP Antibodies)/NPR2 (show NPRL2 Antibodies) signaling is essential for oocyte meiotic arrest in early antral follicles and activated LH/amphiregulin (show AREG Antibodies)/EGFR (show EGFR Antibodies) signaling pathway suppresses this signal by downregulating Nppc (show NPPC Antibodies) expression.
NPPC (show NPPC Antibodies)/NPR2 (show NPRL2 Antibodies) signaling is essential for oocyte meiotic arrest and cumulus oophorus formation, which affects female fertility through the production of oocytes with developmental capacity.
Data suggest mutations in NPR2 (show NPRL2 Antibodies) in patients with skeletal overgrowth alter conformation: A488P/R655C missense mutations yield conformation mimicking allosterically activated NPR2 (show NPRL2 Antibodies); A488P mutation sets phosphorylation as requirement for CNP (show CNP Antibodies)-dependent activation; R655C mutation abrogates need for phosphorylation; ATP analog inhibits mutants. (NPR2 (show NPRL2 Antibodies) = atrial natriuretic factor (show NPPA Antibodies) receptor B; CNP (show CNP Antibodies) = C-type natriuretic peptide (show NPPC Antibodies))
Heterozygous mutation in NPR2 (show NPRL2 Antibodies) gene is associated with short stature.
Mutations in three genes (GDF5 (show GDF5 Antibodies), NPR2 (show NPRL2 Antibodies), BMPR1B (show BMPR1B Antibodies)) have been reported to cause different forms of acromesomelic dysplasia
IL1R2 (show IL1R2 Antibodies) hypomethylation and androgen receptor (show AR Antibodies) hypermethylation may constitute an important determinant of disease severity, whereas NPR2 (show NPRL2 Antibodies) hypomethylation and SP140 (show SP140 Antibodies) hypermethylation may provide a biomarker for vulnerability to excessive daytime sleepiness in Obstructive Sleep Apnea
Loss-of-function mutations of the NPR2 (show NPRL2 Antibodies) gene is associated with acromesomelic dysplasia, type maroteaux.
NPR2 (show NPRL2 Antibodies) mutations account for approximately 3% of patients with disproportionate short stature and/or clinical or radiographic indicators of SHOX (show SHOX Antibodies) deficiency and in whom no SHOX (show SHOX Antibodies) defect has been identified.
3 consanguineous families segregating Acromesomelic dysplasia Maroteaux type in an autosomal recessive manner studied. Linkage in the families was established to the NPR2 (show NPRL2 Antibodies) gene on chromosome 9p12-21. Sequence analysis revealed 2 novel missense variants (p.Arg601Ser; p.Arg749Trp) in 2 families and a previously reported splice site variant (c.2986+2T>G) in the third family.
Cardiac fibrosis and the endogenous natriuretic peptide system were evaluated in end-stage heart failure to assess the anti-fibrotic actions of the dual GC-A (show NPR1 Antibodies)/-B activator.
Gene expression of C-type natriuretic peptide (show NPPC Antibodies) and of its specific receptor NPR-B in human leukocytes of healthy and heart failure subjects
Molecular dynamics analysis indicated decreases in the values of Van (show TNIP1 Antibodies) der (show GDF3 Antibodies) Waals, electrostatic energy and potential energy of NPRB/Vasonatrin peptide compared to NPRA (show NPR1 Antibodies)/Vasonatrin peptide.
These data support the existence of a novel transducing cascade, involving Galpha (show SUCLG1 Antibodies)(q16)beta gamma coupling M(3)AChR to NPR (show NPTXR Antibodies)-GC.
NPR-B is a highly regulated nano-machinery with domains acting at cross-talk points with other signal transducing cascades initiated by G protein-coupled receptors
ATP is not required for the initial activation of natriuretic peptide receptor A (show NPR1 Antibodies) and B, but does increase activity over time by reducing the apparent K(m) for GTP (show AK3 Antibodies).
This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type.
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
, natriuretic peptide receptor 2
, Nppb receptor
, atrial natriuretic peptide receptor 2
, atrial natriuretic peptide receptor type B
, guanylate cyclase B
, guanylyl cyclase-B
, natriuretic peptide receptor B type
, atrial natriuretic peptide B-type receptor
, atrial natriuretic peptide receptor B
, natriuretic peptide receptor-B
, atrionatriuretic peptide receptor B