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The protein encoded by NEDD9 is a member of the CRK-associated substrates family. Additionally we are shipping NEDD9 Kits (7) and NEDD9 Proteins (6) and many more products for this protein.
Showing 10 out of 67 products:
Human Monoclonal NEDD9 Primary Antibody for ICC, IF - ABIN151219
Pugacheva, Golemis: The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome. in Nature cell biology 2005
Show all 3 Pubmed References
Mouse (Murine) Monoclonal NEDD9 Primary Antibody for ICC, FACS - ABIN108572
ONeill, Golemis: Proteolysis of the docking protein HEF1 and implications for focal adhesion dynamics. in Molecular and cellular biology 2001
Show all 3 Pubmed References
Human Monoclonal NEDD9 Primary Antibody for IF, ELISA - ABIN561951
Li, Grupe, Rowland, Holmans, Segurado, Abraham, Jones, Catanese, Ross, Mayo, Martinez, Hollingworth, Goate, Cairns, Racette, Perlmutter, ODonovan, Morris, Brayne, Rubinsztein, Lovestone, Thal, Owen et al.: Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease. ... in Human molecular genetics 2008
The protein expression level of NEDD9 is higher in esophageal carcinoma tissues than that in adjacent normal tissues. Knockdown of NEDD9 expression can restrain the proliferation, invasion and migration of EC109 cells.
NEDD9 was able to partially overcome the inhibitory effects of miR (show MLXIP Antibodies)-203 on colorectal cancer cell colony formation and invasion.
Increased NEDD9 expression is associated with metastatic endometrial and lung cancers.
NEDD9 has an essential role in development as well as in neoplastic cell proliferation, apoptosis, adhesion, migration and invasion. (Review)
The presence of the dna fragment in the NSCLC-N6-L16 (show MRPL16 Antibodies) cell ChIP assays demonstrated a physical link between NEDD9 and p53 (show TP53 Antibodies).
siRNA suppression of NEDD9 inhibits proliferation and enhances apoptosis in renal cell carcinoma (show MOK Antibodies).
Serum NEDD9 was elevated in gastric cancer patients and had an unfavorable prognostic effect.
BCAR3 (show BCAR3 Antibodies) is an essential interactor and mediator of HEF1-induced migration.
Study uncovers a new role of NEDD9 as a regulator of integrin trafficking through CAV1 (show CAV1 Antibodies)-dependent endocytosis, and provide new insight into the regulation of migration of breast cancer cells.
miR145 is inversely correlated with NEDD9 expression in pancreatic cancer tissues and restoration of miR145 in Panc1 cells reduced NEDD9 mRNA and protein expression accompanied by inhibition of cell proliferation, invasion and migration.
These results suggest that Nedd9 is a Smad2 (show SMAD2 Antibodies)/3 target gene implicated in RANKL (show TNFSF11 Antibodies)-induced osteoclastogenesis.
NEDD9 is required for the maintenance of dendritic spines in the hippocampus.
Thus the RARE upstream of the Nedd9 2B promoter is necessary for much of the endogenous gene expression during early development as well as ectopic expression in response to atRA.
suggest that Cas-L/NEDD9 plays a pivotal role in the pathophysiology of CIA (show NCOA5 Antibodies), and that Cas-L/NEDD9 may be a potential molecular target for the treatment of RA
Data indicate that Src kinase (show CSK Antibodies) modulates the transit time of NEDD9 (neural precursor cell expressed developmentally down-regulated gene 9) at focal adhesion sites.
These results indicated an important modifier action of Nedd9 on autosomal dominant polycystic kidney disease pathogenesis involving failure to activate Aurora-A (show AURKA Antibodies).
these results indicate a functional requirement for NEDD9 in the growth of mammary cancer progenitor cells
Tyrosine Y189 in the substrate domain of the adhesion docking protein NEDD9 is conserved with p130Cas (show BCAR1 Antibodies) Y253 and regulates NEDD9-mediated migration and focal adhesion dynamics.
Collectively our data suggest that NEDD9 may promote 3D cell migration by slowing focal adhesion disassembly, promoting integrin receptor activation and increasing adhesion force
The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants.
neural precursor cell expressed, developmentally down-regulated 9
, enhancer of filamentation 1 homolog
, Cas scaffolding protein family member 2
, Crk-associated substrate related protein Cas-L
, Enhancer of filamentation 1 p55
, cas-like docking
, enhancer of filamentation 1
, neural precursor cell expressed developmentally down-regulated protein 9
, p130Cas-related protein
, renal carcinoma antigen NY-REN-12
, neural precursor cell expressed, developmentally down-regulated gene 9
, CRK-associated substrate-related protein
, Crk-associated substrate lymphocyte-specific protein