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May regulate RNA splicing or metabolism in a specific subset of developing neurons (By similarity). Additionally we are shipping NOVA2 Proteins (2) and many more products for this protein.
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SCN1A (show SCN1A Antibodies) polymorphism has a dramatic effect on the proportions of neonate and adult alternative transcripts of SCN1A (show SCN1A Antibodies) in adult brain tissue and, the effect of the polymorphism also appears to be modified by Nova2 expression levels.
Phenotypic analysis of the NOVA (show HNRNPK Antibodies)-deficient mice demonstrated increased adipose tissue thermogenesis and improved glycemia.
These results reveal that Nova2 functions as an AS regulator in angiogenesis and is a novel member of the angioneurins family.
integrative network revealed combinatorial regulation by Nova (show HNRNPK Antibodies) and the neuronal splicing factor (show SLU7 Antibodies) Fox, interplay between phosphorylation and splicing, and potential links to neurologic disease
Nova2 regulates an RNA switch controlling the ability of Dab1 (show DAB1 Antibodies) to mediate neuronal responsiveness to reelin (show RELN Antibodies) signaling and neuronal migration, suggesting new links between splicing regulation, brain disease, and development.
CLIP (cross-linking and immunoprecipitation) reveals Nova (show HNRNPK Antibodies) coordinately regulates a biologically coherent set of RNAs encoding multiple components of the inhibitory synapse, an observation that may relate to the cause of abnormal motor inhibition in POMA
Assays of splicing intermediates of Nova (show HNRNPK Antibodies)-regulated transcripts in mouse brain revealed that Nova (show HNRNPK Antibodies) preferentially regulates removal of introns harbouring (or closest to) YCAY clusters
the neuron-specific splicing factor (show SLU7 Antibodies) Nova (show HNRNPK Antibodies) revealed extremely reproducible RNA-binding maps in multiple mouse brains
Nova1/Nova2 double knockout mice are paralyzed and fail to cluster AChRs at the neuromuscular junction, and breeding them with transgenic mice constitutively expressing Z(+) agrin (show AGRN Antibodies) in motor neurons rescued AChR clustering
May regulate RNA splicing or metabolism in a specific subset of developing neurons (By similarity). Binds single strand RNA.
neuro-oncological ventral antigen 2
, neurological oncogenic ventral antigen protein
, RNA-binding protein Nova-2
, astrocytic NOVA1-like RNA-binding protein
, neuro-oncological ventral antigen 3
, neuro-oncological ventral antigen 1