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anti-Neurofibromin 1 (NF1) Antibodies

NF1 product appears to function as a negative regulator of the ras signal transduction pathway. Additionally we are shipping Neurofibromin 1 Kits (5) and Neurofibromin 1 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NF1 18015 Q04690
NF1 4763 P21359
NF1 24592 P97526
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Top anti-Neurofibromin 1 Antibodies at antibodies-online.com

Showing 10 out of 122 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IF, ELISA, WB Western blot analysis of extracts from HepG2 cells, using NF1 Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of HepG2 cells, using NF1 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Guinea Pig Mouse Un-conjugated IHC (p), IP, ELISA, WB 0.2 mL Log in to see 5 to 7 Days
$381.94
Details
Guinea Pig Mouse Un-conjugated IHC (p), IP, IHC, ELISA Immunocytochemical staining of adult human dorsal root ganglia, using ABIN152499. 0.2 mL Log in to see 5 to 7 Days
$381.94
Details
Human Rabbit Un-conjugated EIA, IF, IHC (p), WB Immunofluorescence analysis of HepG2 cells, using NF1 Antibody. The picture on the right is treated with the synthesized peptide. Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IF, IHC (p), ELISA, WB Anti-NF1 antibody IHC staining of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN959354 dilution 1:100. Anti-NF1 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN959354 dilution 1:100. 50 μL Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IP, WB Detection of human NF1 in Western Blot and immunoprecipitation, using ABIN151878.  Samples:  mock treated (control) or NF1-siRNA treated HeLa WCE (A – 40 ug, B – 200 ug).  Immunoprecipitated NF was detected using an antibody from another vendor.  Exposure times of (A) 1 minute or (B) 10 seconds. Western Blot: Neurofibromin 1 Antibody [ABIN151878] - Whole cell lysate from HeLa cells. 100 μL Log in to see 5 to 7 Days
$486.94
Details
Chicken Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of NF1 staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of NF1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated ICC, IHC (fro), IF, IHC (p), IHC, WB Immunohistochemistry: Neurofibromin 1 Antibody [ABIN152500] - NF1 protein labeling displays positive signal in the maturing and the hypertrophic cartilages but only faint labeling in the proliferative cartilage. Western Blot: Neurofibromin 1 Antibody [ABIN152500] - Western Blot of (A, B, C above). 0.5 mL Log in to see 5 to 7 Days
$408.19
Details
Human Rabbit Un-conjugated ELISA, IF, WB 100 μL Log in to see 14 Days
$175.80
Details

NF1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Neurofibromin 1 Antibodies

  1. Human Polyclonal Neurofibromin 1 Primary Antibody for ICC, IHC (fro) - ABIN152500 : Kuorilehto, Ekholm, Nissinen, Hietaniemi, Hiltunen, Paavolainen, Penttinen, Peltonen: NF1 gene expression in mouse fracture healing and in experimental rat pseudarthrosis. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2006 (PubMed)
    Show all 4 references for ABIN152500

  2. Guinea Pig Monoclonal Neurofibromin 1 Primary Antibody for IHC (p), IP - ABIN152499 : Hisaoka, Hashimoto, Ohguri, Aoki, Okamoto, Tanaka, Okimoto, Nakamura, Ishida: Congenital (infantile) pseudarthrosis of the fibula associated with osteofibrous dysplasia. in Skeletal radiology 2004 (PubMed)
    Show all 3 references for ABIN152499

  3. Human Polyclonal Neurofibromin 1 Primary Antibody for IF, ELISA - ABIN1534476 : Wallace, Marchuk, Andersen, Letcher, Odeh, Saulino, Fountain, Brereton, Nicholson, Mitchell: Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients. in Science (New York, N.Y.) 1990 (PubMed)
    Show all 2 references for ABIN1534476

  4. Guinea Pig Monoclonal Neurofibromin 1 Primary Antibody for IHC (p), IP - ABIN152498 : Tucker, Riccardi, Brown, Fee, Sutcliffe, Vielkind, Wechsler, Wolkenstein, Friedman: S100B and neurofibromin immunostaining and X-inactivation patterns of laser-microdissected cells indicate a multicellular origin of some NF1-associated neurofibromas. in Journal of neuroscience research 2011 (PubMed)

More Antibodies against Neurofibromin 1 Interaction Partners

Fruit Fly (Drosophila melanogaster) Neurofibromin 1 (NF1) interaction partners

  1. Polymorphism in the neurofibromin gene, Nf1, is associated with antagonistic selection on wing size and development time in Drosophila melanogaster.

  2. The N-terminal region of NF1 mediates the interaction with Fak56 and is required for the signaling activity and presynaptic localization of NF1

  3. These results identify dAlk as an upstream activator of dNf1-regulated Ras signaling responsible for several dNf1 defects, and they implicate human Alk (show ALK Antibodies) as a potential therapeutic target in NF1

  4. memory-related functions of Rut (show ADCY5 Antibodies)-AC are both Nf1-dependent and -independent, that Nf1 mediates the formation of two distinct memory components within a single neuron population.

  5. survival of a subset of midline glia cells depends upon direct suppression of the proapoptotic protein HID via the EGF receptor (show EGFR Antibodies)/RAS/MAPK (show MAPK1 Antibodies) pathway

  6. role in insulin (show INS Antibodies)-mediated proliferation of Schneider cells

  7. preliminary crystallographic characterization of a novel segment (homologous to the yeast Sec14p lipid exchange protein) from the neurofibromatosis type 1 protein

  8. Effect of neurofibromatosis type I mutations on a novel pathway for adenylyl cyclase activation requiring neurofibromin and Ras

  9. Loss of NF1 can give rise to non-cell-autonomous developmental defects, implicate aberrant Ras-mediated signaling in larval neurons as the primary cause of the NF1 growth deficiency.

  10. Neurofibromin regulates longevity and stress resistance through cAMP regulation of mitochondrial respiration and ROS (show ROS1 Antibodies) production, and NF1 may be treatable using catalytic antioxidants.

Cow (Bovine) Neurofibromin 1 (NF1) interaction partners

  1. DNA variants in the NF1 gene are associated with genetic disposition to bovine spongiform encephalopathy.

Zebrafish Neurofibromin 1 (NF1) interaction partners

  1. study shows negative regulation of Ras (show RAB1A Antibodies) pathway through GAP activity of NF1 limits oligodendrocyte progenitor cell (OPC) proliferation and motility during development; provides insight into oncogenic mechanisms by which NF1 loss contributes to glial tumors

  2. identification and characterization of nf1a and nf1b, orthologues of NF1, that show neural crest and cardiovascular defects resulting from morpholino knockdown, including vascular and cardiac valvular abnormalities

Mouse (Murine) Neurofibromin 1 (NF1) interaction partners

  1. Spatially- and temporally-controlled postnatal p53 (show TP53 Antibodies) knockdown cooperates with embryonic Schwann cell precursor Nf1 gene loss to promote malignant peripheral nerve sheath tumor formation.

  2. These findings demonstrate a role for Ras-GAP (show RASA1 Antibodies) activity in suppressing the hemogenic potential of the heart and restricting growth of neural crest-derived tissues.

  3. identified p21Ras-dependent hyperphosphorylation of Pu.1 within the nucleus of Nf1 haploinsufficient myelomonocytic osteoclast precursors, providing a novel therapeutic target for the potential treatment of NF1 associated osteolytic manifestations.

  4. Targeted gene deletion of TP53 (show TP53 Antibodies), Pten (show PTEN Antibodies), and NF1 in mouse brain causes glioblastoma.

  5. Data indicated a critical role for Nf1 in regulating multiple mesenchymal stem/progenitor cells functions, including migration and adhesion through both the PI3-K (show PIK3CA Antibodies) and MAPK (show MAPK1 Antibodies) pathways.

  6. this is the first demonstration that different germline NF1 gene mutations differentially dictate neurofibromin function in the brain.

  7. Data suggest that bi-allelic loss of Nf1 induces autonomous adrenal hyper-activity. Nf1 seems involved in the regulation of adrenal cortex function in mice and humans.

  8. FGFR1 (show FGFR1 Antibodies) signaling in hypertrophic chondrocytes is attenuated by the Ras-GAP (show RASA1 Antibodies) neurofibromin during endochondral bone formation

  9. Low levels of NF1 expression were associated with primary and acquired resistance of lung adenocarcinomas to EGFR (show EGFR Antibodies) Thymidine Kinase (show TK1 Antibodies) Inhibitors in patients.

  10. eurofibromin differentially controls neural stem cell (NSC) proliferation and multilineage differentiation through the selective use of the PI3K/AKT (show AKT1 Antibodies) and RAF (show RAF1 Antibodies)/MEK (show MDK Antibodies) pathways

Human Neurofibromin 1 (NF1) interaction partners

  1. A significant correlation between neurofibromin expression and colorectal tumor localization was found, with tumors arising in the colon showing intense NF expression more often than those arising in the rectum; higher expression of NF was more common in tumors not responding to treatment; and tumors with multiple metastases showed higher expression of NF than those with single metastasis

  2. mutation in the NF1 gene is associated with Neurofibromatosis-Noonan Syndrome.

  3. the computational model results have added credibility to the experimental hypothesis of a genetic cause (i.e. Nf1 mutation) for Congenital pseudarthrosis of the tibia

  4. The pattern of growth differs substantially in deletion and non-deletion neurofibromatosis 1 patients, but the pathogenic basis for this difference is unknown.

  5. Fine mapping of meiotic NAHR-associated crossovers causing large NF1 deletions has been reported.

  6. Neurofibromin mediates Ras deactivation.

  7. NF1 mutation is not associated with the risk of optic pathway glioma in Neurofibromatosis type 1 patients.

  8. proposed technique is cheap and reliable, and could ideally be performed as a preliminary biochemical screening before molecular analysis of the Neurofibromatosis type 1 gene

  9. Of the ten reported cases of NF1 due to R681X, one has presented with optic glioma and none with precocious puberty.

  10. Thirty distinct NF1 mutations were identified in 32 patients. Thirteen mutations were novel and most were frameshift mutations (33.3%).

Neurofibromin 1 (NF1) Antigen Profile

Protein Summary

This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene.

Gene names and symbols associated with anti-Neurofibromin 1 (NF1) Antibodies

  • neurofibromin 1 (NF1) antibody
  • Neurofibromin 1 (Nf1) antibody
  • neurofibromin 1a (nf1a) antibody
  • neurofibromin (NF1) antibody
  • neurofibromin (AaeL_AAEL008371) antibody
  • neurofibromin (CpipJ_CPIJ011774) antibody
  • neurofibromin (Smp_148460) antibody
  • neurofibromin (LOC100349438) antibody
  • neurofibromatosis 1 (Nf1) antibody
  • neurofibromin 1 (Nf1) antibody
  • AW494271 antibody
  • CG8318 antibody
  • Dmel\\CG8318 antibody
  • dNF1 antibody
  • E030030H24Rik antibody
  • fe06d03 antibody
  • hm:zehn0874 antibody
  • Nf-1 antibody
  • nf1 antibody
  • NFNS antibody
  • VRNF antibody
  • WSS antibody
  • wu:fe06d03 antibody
  • zehn0874 antibody

Protein level used designations for anti-Neurofibromin 1 (NF1) Antibodies

neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease) , CG8318-PB , CG8318-PC , CG8318-PD , CG8318-PE , CG8318-PF , Neurofibromatosis-1 , Nf1-PB , Nf1-PC , Nf1-PD , Nf1-PE , Nf1-PF , neurofibramatosis-1 , neurofibromatosis 1 , neurofibromatosis factor 1 , neurofibromatosis type 1 , neurofibromin , neurofibromin 1 , neurofibromin-like , neurofibromatosis-related protein NF-1 , Neurofibromatosis type 1

GENE ID SPECIES
100071896 Equus caballus
43149 Drosophila melanogaster
280877 Bos taurus
326708 Danio rerio
454566 Pan troglodytes
493675 Felis catus
531372 Bos taurus
593418 Strongylocentrotus purpuratus
100023872 Monodelphis domestica
100392547 Callithrix jacchus
100482656 Ailuropoda melanoleuca
100546215 Meleagris gallopavo
100603967 Nomascus leucogenys
712911 Macaca mulatta
5570549 Aedes aegypti
6045114 Culex quinquefasciatus
8341839 Schistosoma mansoni
100349438 Oryctolagus cuniculus
18015 Mus musculus
4763 Homo sapiens
24592 Rattus norvegicus
100730274 Cavia porcellus
396085 Gallus gallus
480618 Canis lupus familiaris
100526136 Sus scrofa
Selected quality suppliers for anti-Neurofibromin 1 (NF1) Antibodies
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