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anti-Neurofibromin 1 (NF1) Antibodies

NF1 product appears to function as a negative regulator of the ras signal transduction pathway. Additionally we are shipping Neurofibromin 1 Kits (5) and Neurofibromin 1 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NF1 18015 Q04690
NF1 4763 P21359
NF1 24592 P97526
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Top anti-Neurofibromin 1 Antibodies at antibodies-online.com

Showing 10 out of 110 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IF, ELISA, WB Western blot analysis of extracts from HepG2 cells, using NF1 Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of HepG2 cells, using NF1 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IF, IHC (p), ELISA, WB Anti-NF1 antibody IHC staining of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN959354 dilution 1:100. Anti-NF1 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN959354 dilution 1:100. 50 μL Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated EIA, IF, IHC (p), WB Immunofluorescence analysis of HepG2 cells, using NF1 Antibody. The picture on the right is treated with the synthesized peptide. Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 6 to 8 Days
$500.50
Details
Chicken Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of NF1 staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of NF1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Mammalian Rabbit Un-conjugated IF, WB   200 μL Log in to see 11 to 16 Days
$436.33
Details
Guinea Pig Mouse Un-conjugated IP, ELISA, WB 0.05 mL Log in to see 5 to 6 Days
$499.80
Details
Guinea Pig Mouse Un-conjugated IHC (p), IP, ELISA 0.05 mL Log in to see 5 to 6 Days
$499.80
Details
Human Rabbit Un-conjugated ELISA, IF, WB 100 μL Log in to see 14 Days
$201.19
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 2 to 3 Days
$302.50
Details

NF1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Neurofibromin 1 Antibodies

  1. Human Polyclonal Neurofibromin 1 Primary Antibody for IF, ELISA - ABIN1534476 : Wallace, Marchuk, Andersen, Letcher, Odeh, Saulino, Fountain, Brereton, Nicholson, Mitchell: Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients. in Science (New York, N.Y.) 1990 (PubMed)
    Show all 2 references for ABIN1534476

More Antibodies against Neurofibromin 1 Interaction Partners

Fruit Fly (Drosophila melanogaster) Neurofibromin 1 (NF1) interaction partners

  1. Polymorphism in the neurofibromin gene, Nf1, is associated with antagonistic selection on wing size and development time in Drosophila melanogaster.

  2. The N-terminal region of NF1 mediates the interaction with Fak56 and is required for the signaling activity and presynaptic localization of NF1

  3. These results identify dAlk as an upstream activator of dNf1-regulated Ras signaling responsible for several dNf1 defects, and they implicate human Alk (show ALK Antibodies) as a potential therapeutic target in NF1

  4. memory-related functions of Rut (show ADCY5 Antibodies)-AC are both Nf1-dependent and -independent, that Nf1 mediates the formation of two distinct memory components within a single neuron population.

  5. survival of a subset of midline glia cells depends upon direct suppression of the proapoptotic protein HID via the EGF receptor (show EGFR Antibodies)/RAS/MAPK (show MAPK1 Antibodies) pathway

  6. role in insulin (show INS Antibodies)-mediated proliferation of Schneider cells

  7. preliminary crystallographic characterization of a novel segment (homologous to the yeast Sec14p lipid exchange protein) from the neurofibromatosis type 1 protein

  8. Effect of neurofibromatosis type I mutations on a novel pathway for adenylyl cyclase activation requiring neurofibromin and Ras

  9. Loss of NF1 can give rise to non-cell-autonomous developmental defects, implicate aberrant Ras-mediated signaling in larval neurons as the primary cause of the NF1 growth deficiency.

  10. Neurofibromin regulates longevity and stress resistance through cAMP regulation of mitochondrial respiration and ROS (show ROS1 Antibodies) production, and NF1 may be treatable using catalytic antioxidants.

Cow (Bovine) Neurofibromin 1 (NF1) interaction partners

  1. DNA variants in the NF1 gene are associated with genetic disposition to bovine spongiform encephalopathy.

Zebrafish Neurofibromin 1 (NF1) interaction partners

  1. study shows negative regulation of Ras (show RAB1A Antibodies) pathway through GAP activity of NF1 limits oligodendrocyte progenitor cell (OPC) proliferation and motility during development; provides insight into oncogenic mechanisms by which NF1 loss contributes to glial tumors

  2. identification and characterization of nf1a and nf1b, orthologues of NF1, that show neural crest and cardiovascular defects resulting from morpholino knockdown, including vascular and cardiac valvular abnormalities

Mouse (Murine) Neurofibromin 1 (NF1) interaction partners

  1. These findings demonstrate a role for Ras-GAP (show RASA1 Antibodies) activity in suppressing the hemogenic potential of the heart and restricting growth of neural crest-derived tissues.

  2. identified p21Ras-dependent hyperphosphorylation of Pu.1 within the nucleus of Nf1 haploinsufficient myelomonocytic osteoclast precursors, providing a novel therapeutic target for the potential treatment of NF1 associated osteolytic manifestations.

  3. Targeted gene deletion of TP53 (show TP53 Antibodies), Pten (show PTEN Antibodies), and NF1 in mouse brain causes glioblastoma.

  4. Data indicated a critical role for Nf1 in regulating multiple mesenchymal stem/progenitor cells functions, including migration and adhesion through both the PI3-K (show PIK3CA Antibodies) and MAPK (show MAPK1 Antibodies) pathways.

  5. this is the first demonstration that different germline NF1 gene mutations differentially dictate neurofibromin function in the brain.

  6. Data suggest that bi-allelic loss of Nf1 induces autonomous adrenal hyper-activity. Nf1 seems involved in the regulation of adrenal cortex function in mice and humans.

  7. FGFR1 (show FGFR1 Antibodies) signaling in hypertrophic chondrocytes is attenuated by the Ras-GAP (show RASA1 Antibodies) neurofibromin during endochondral bone formation

  8. Low levels of NF1 expression were associated with primary and acquired resistance of lung adenocarcinomas to EGFR (show EGFR Antibodies) Thymidine Kinase (show TK1 Antibodies) Inhibitors in patients.

  9. eurofibromin differentially controls neural stem cell (NSC) proliferation and multilineage differentiation through the selective use of the PI3K/AKT (show AKT1 Antibodies) and RAF (show RAF1 Antibodies)/MEK (show MDK Antibodies) pathways

  10. Double-deficient RASA1 (show RASA1 Antibodies)-neurofibromin 1 mice developed T cell acute lymphoblastic leukemia/lymphoma, which originated at an early point in T cell development and was dependent on activating mutations in the Notch1 (show NOTCH1 Antibodies) gene.

Human Neurofibromin 1 (NF1) interaction partners

  1. Neurofibromin mediates Ras deactivation.

  2. NF1 mutation is not associated with the risk of optic pathway glioma in Neurofibromatosis type 1 patients.

  3. proposed technique is cheap and reliable, and could ideally be performed as a preliminary biochemical screening before molecular analysis of the Neurofibromatosis type 1 gene

  4. Of the ten reported cases of NF1 due to R681X, one has presented with optic glioma and none with precocious puberty.

  5. Thirty distinct NF1 mutations were identified in 32 patients. Thirteen mutations were novel and most were frameshift mutations (33.3%).

  6. Constitutional missense mutations at p.Arg1809 affect 1.23% of unrelated NF1 probands in the UAB cohort, therefore this specific NF1 genotype-phenotype correlation will affect counseling and management of a significant number of patients.

  7. Data suggest SPRED1 (show SPRED1 Antibodies) EVH1 domain interacts with NF1 GRD domain [N-term. 16AA/C-term. 20AA of GTPase-activating protein (show RASA1 Antibodies)-related domain]; SPRED1 (show SPRED1 Antibodies) EVH1 and NF1 GRD mutations observed in Legius syndrome reduce binding affinity between EVH1/GRD domains.

  8. Novel 1948delT and 541C>T mutations in NF1 associated with sporadic neurofibromatosis type 1.

  9. This study suggests that inactivating NF1 mutations outside the context of neurofibromatosis may be the oncogenic mechanism for a subset of sporadic gastrointestinal stromal tumors

  10. The complexity of the splicing regulatory elements present in exon 9 is most likely responsible for the fact that mutations in this region represent 25% of all exonic changes that affect splicing in the NF1 gene.

Neurofibromin 1 (NF1) Antigen Profile

Protein Summary

This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene.

Gene names and symbols associated with anti-Neurofibromin 1 (NF1) Antibodies

  • neurofibromin 1 (NF1) antibody
  • Neurofibromin 1 (Nf1) antibody
  • neurofibromin 1a (nf1a) antibody
  • neurofibromin (NF1) antibody
  • neurofibromin (AaeL_AAEL008371) antibody
  • neurofibromin (CpipJ_CPIJ011774) antibody
  • neurofibromin (Smp_148460) antibody
  • neurofibromin (LOC100349438) antibody
  • neurofibromatosis 1 (Nf1) antibody
  • neurofibromin 1 (Nf1) antibody
  • AW494271 antibody
  • CG8318 antibody
  • Dmel\\CG8318 antibody
  • dNF1 antibody
  • E030030H24Rik antibody
  • fe06d03 antibody
  • hm:zehn0874 antibody
  • Nf-1 antibody
  • nf1 antibody
  • NFNS antibody
  • VRNF antibody
  • WSS antibody
  • wu:fe06d03 antibody
  • zehn0874 antibody

Protein level used designations for anti-Neurofibromin 1 (NF1) Antibodies

neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease) , CG8318-PB , CG8318-PC , CG8318-PD , CG8318-PE , CG8318-PF , Neurofibromatosis-1 , Nf1-PB , Nf1-PC , Nf1-PD , Nf1-PE , Nf1-PF , neurofibramatosis-1 , neurofibromatosis 1 , neurofibromatosis factor 1 , neurofibromatosis type 1 , neurofibromin , neurofibromin 1 , neurofibromin-like , neurofibromatosis-related protein NF-1 , Neurofibromatosis type 1

GENE ID SPECIES
100071896 Equus caballus
43149 Drosophila melanogaster
280877 Bos taurus
326708 Danio rerio
454566 Pan troglodytes
493675 Felis catus
531372 Bos taurus
593418 Strongylocentrotus purpuratus
100023872 Monodelphis domestica
100392547 Callithrix jacchus
100482656 Ailuropoda melanoleuca
100546215 Meleagris gallopavo
100603967 Nomascus leucogenys
712911 Macaca mulatta
5570549 Aedes aegypti
6045114 Culex quinquefasciatus
8341839 Schistosoma mansoni
100349438 Oryctolagus cuniculus
18015 Mus musculus
4763 Homo sapiens
24592 Rattus norvegicus
100730274 Cavia porcellus
396085 Gallus gallus
480618 Canis lupus familiaris
100526136 Sus scrofa
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