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anti-Neurofibromin 2 (NF2) Antibodies

NF2 encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. Additionally we are shipping Neurofibromin 2 Kits (13) and Neurofibromin 2 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NF2 18016 P46662
NF2 4771 P35240
NF2 25744 Q63648
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Top anti-Neurofibromin 2 Antibodies at antibodies-online.com

Showing 10 out of 161 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IF, IHC (p), WB Western blot analysis of Merlin Antibody (N-term) (ABIN390756) in NCI-... Merlin Antibody (N-term) (ABIN390756) IHC analysis in formalin fixed a... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from NIH-3T3 cells treated with IFN ... Immunohistochemistry analysis of paraffin-embedded human breast carcin... 100 μg Log in to see 2 to 3 Days
$275.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of Merlin Antibody (N-term) in NCI-H460 cell lin... 0.4 mL Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from RAW264.7 cells, using Merlin (A... 100 μg Log in to see 2 to 3 Days
$275.00
Details
Human Rabbit Un-conjugated IP, IHC, ELISA, WB 100 μg Log in to see 2 to 3 Days
$369.00
Details
Human Rabbit Un-conjugated EIA, WB Immunoblotting. Affinity purified phosphospecific antibody to NF2 (Mer... 0.1 mg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IHC (p), WB 0.1 mL Log in to see 6 to 8 Days
$308.00
Details
Human Rabbit Un-conjugated IF, WB 0.1 mL Log in to see 6 to 8 Days
$357.50
Details
Zebrafish Goat Un-conjugated EIA, IHC (p)   0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Chicken Goat Un-conjugated EIA, IHC (p) 50 μg Log in to see 6 to 8 Days
$500.50
Details

NF2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Mouse (Murine) , , , ,
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Human , , , ,
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Rat (Rattus) , , , ,

Top referenced anti-Neurofibromin 2 Antibodies

  1. Human Polyclonal NF2 Primary Antibody for IHC (p), WB - ABIN197520 : Xiao, Gallagher, Shetler, Skele, Altomare, Pestell, Jhanwar, Testa: The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression. in Molecular and cellular biology 2005 (PubMed)
    Show all 4 references for ABIN197520

  2. Human Polyclonal NF2 Primary Antibody for IF, WB - ABIN197028 : Yang, Hinds: Phosphorylation of ezrin by cyclin-dependent kinase 5 induces the release of Rho GDP dissociation inhibitor to inhibit Rac1 activity in senescent cells. in Cancer research 2006 (PubMed)
    Show all 4 references for ABIN197028

  3. Human Polyclonal NF2 Primary Antibody for IHC, ELISA - ABIN1532019 : Yu, Zeidel, Hill: Cellular expression profile for interstitial cells of cajal in bladder - a cell often misidentified as myocyte or myofibroblast. in PLoS ONE 2012 (PubMed)
    Show all 3 references for ABIN1532019

  4. Human Polyclonal NF2 Primary Antibody for EIA, WB - ABIN117953 : Gutmann, Wright, Geist, Snider: Expression of the neurofibromatosis 2 (NF2) gene isoforms during rat embryonic development. in Human molecular genetics 1995 (PubMed)
    Show all 2 references for ABIN117953

  5. Human Polyclonal NF2 Primary Antibody for IP, IHC - ABIN104130 : Wang, Lu, Tang, Wang, Wu: The phosphorylation status of merlin in sporadic vestibular Schwannomas. in Molecular and cellular biochemistry 2009 (PubMed)
    Show all 2 references for ABIN104130

  6. Human Polyclonal NF2 Primary Antibody for ELISA, WB - ABIN1533058 : Trofatter, MacCollin, Rutter, Murrell, Duyao, Parry, Eldridge, Kley, Menon, Pulaski: A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor. in Cell 1993 (PubMed)
    Show all 2 references for ABIN1533058

  7. Zebrafish (Danio rerio) Polyclonal NF2 Primary Antibody for EIA, IHC (p) - ABIN401528 : Sadler, Amsterdam, Soroka, Boyer, Hopkins: A genetic screen in zebrafish identifies the mutants vps18, nf2 and foie gras as models of liver disease. in Development (Cambridge, England) 2005 (PubMed)

  8. Human Polyclonal NF2 Primary Antibody for EIA, WB - ABIN453191 : James, Han, Polizzano, Plotkin, Manning, Stemmer-Rachamimov, Gusella, Ramesh: NF2/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growth. in Molecular and cellular biology 2009 (PubMed)

More Antibodies against Neurofibromin 2 Interaction Partners

Zebrafish Neurofibromin 2 (NF2) interaction partners

  1. Mutation of nf2 gene develops extrahepatic choledochal cysts in the common bile duct

Mouse (Murine) Neurofibromin 2 (NF2) interaction partners

  1. loss of axonal contact following nerve injury results in merlin phosphorylation leading to increased p75(NTR (show NGFR Antibodies)) expression.

  2. Loss of Nf2 and Cdkn2a (show CDKN2A Antibodies)/b have synergistic effects with PDGF-B (show PDGFB Antibodies) overexpression promoting meningioma malignant transformation.

  3. Merlin 1 and 2 act as tumor suppressors and are required for optimal sperm maturation

  4. Together our results uncover miRNAs as yet another negative mechanism controlling Merlin tumor suppressor functions.

  5. Merlin and Ezrin (show EZR Antibodies) are components of a mechanism where mechanical forces associated with cell junctions are transduced across the cell cortex via cortical actomyosin cytoskeleton to control lateral mobility and activity of epidermal growth factor receptor (show EGFR Antibodies).

  6. The study describe a novel NF2 mouse model recapitulating schwannoma phenotypes found in human patients where tumors develop in the cranial nerve VIII (show COX8A Antibodies) and/or the spinal roots.

  7. Nf2/Merlin controls spinal cord neural progenitor function in a Rac1/ErbB2 (show ERBB2 Antibodies)-dependent manner.

  8. Nf2-Yap signaling plays important roles in controlling the expansion of dorsal root ganglia progenitors and glia during DRG development

  9. CD44 (show CD44 Antibodies) cytoplasmic tail cleaved by RIP (show HRB Antibodies) could release DCAF1 (show VPRBP Antibodies) from merlin by competing for binding to the merlin FERM domain, which results in the inhibition of merlin-mediated suppression of tumorigenesis.

  10. Findings indicate that merlin is sumoylated and that this post-translational modification is essential for tumor suppression.

Human Neurofibromin 2 (NF2) interaction partners

  1. NF2/merlin inactivation augments mutant RAS signaling by promoting YAP (show YAP1 Antibodies)/TEAD-driven transcription of oncogenic and wild-type RAS, resulting in greater MAPK (show MAPK1 Antibodies) output and increased sensitivity to MEK (show MAP2K1 Antibodies) inhibitors.

  2. Loss of Nf2 and Cdkn2a (show CDKN2A Antibodies)/b have synergistic effects with PDGF-B (show PDGFB Antibodies) overexpression promoting meningioma malignant transformation.

  3. we demonstrate that NF2 negatively controls the invasiveness of Glioblastoma multiforme through YAP (show YAP1 Antibodies)-dependent induction of CYR61/CCN1 (show CYR61 Antibodies) and miR (show MLXIP Antibodies)-296-3p.

  4. angiomotin and Merlin respectively interface cortical actin filaments and core kinases in Hippo signaling

  5. (Delta2-4)Merlin variant disrupts the normal function of Merlin and promotes hepatocellular carcinoma metastasis.

  6. Stusies indicate that monosomy 22, which is often associated with mutations of the neurofibromin 2 (NF2) gene, has emerged as the most frequent alteration of meningiomas.

  7. Together our results uncover miRNAs as yet another negative mechanism controlling Merlin tumor suppressor functions.

  8. NF2 (frequently deleted in MPM) inhibited Snail (show SNAI1 Antibodies)-mediated p53 (show TP53 Antibodies) suppression and was stabilized by RKIP (show PEBP1 Antibodies).

  9. findings demonstrated that Merlin critically regulated pancreatic cancer pathogenesis by suppressing FOXM1 (show FOXM1 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling

  10. Mutation in NF2 gene is associated with malignant peritoneal mesothelioma.

Neurofibromin 2 (NF2) Antigen Profile

Protein Summary

This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development\; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.

Gene names and symbols associated with anti-Neurofibromin 2 (NF2) Antibodies

  • neurofibromin 2b (merlin) (nf2b) antibody
  • neurofibromin 2 (bilateral acoustic neuroma) (NF2) antibody
  • neurofibromin 2 (merlin) (NF2) antibody
  • neurofibromin 2 (NF2) antibody
  • neurofibromin 2 (LOC100357691) antibody
  • merlin-like (LOC417537) antibody
  • neurofibromatosis 2 (Nf2) antibody
  • neurofibromin 2 (merlin) (Nf2) antibody
  • neurofibromin 2a (merlin) (nf2a) antibody
  • ACN antibody
  • BANF antibody
  • merlin antibody
  • NF2 antibody
  • NF2a antibody
  • SCH antibody
  • zgc:194620 antibody
  • zgc:194631 antibody

Protein level used designations for anti-Neurofibromin 2 (NF2) Antibodies

neurofibromin 2 (bilateral acoustic neuroma) , merlin , neurofibromatosis 2 , neurofibromin 2 , moesin-ezrin-radixin-like protein , neurofibromin-2 , schwannomin , moesin-ezrin-radixin like , moesin-ezrin-radizin-like protein , schwannomerlin

GENE ID SPECIES
405887 Danio rerio
395158 Gallus gallus
100058977 Equus caballus
100329097 Saccoglossus kowalevskii
100357691 Oryctolagus cuniculus
417537 Gallus gallus
18016 Mus musculus
4771 Homo sapiens
25744 Rattus norvegicus
477535 Canis lupus familiaris
100520699 Sus scrofa
540479 Bos taurus
561184 Danio rerio
Selected quality suppliers for anti-Neurofibromin 2 (NF2) Antibodies
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