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NF2 encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. Additionally we are shipping Neurofibromin 2 Kits (14) and Neurofibromin 2 Proteins (7) and many more products for this protein.
Showing 10 out of 170 products:
Human Polyclonal NF2 Primary Antibody for IHC (p), WB - ABIN197520
Xiao, Gallagher, Shetler, Skele, Altomare, Pestell, Jhanwar, Testa: The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression. in Molecular and cellular biology 2005
Show all 4 references for ABIN197520
Human Polyclonal NF2 Primary Antibody for IF, WB - ABIN197028
Yang, Hinds: Phosphorylation of ezrin by cyclin-dependent kinase 5 induces the release of Rho GDP dissociation inhibitor to inhibit Rac1 activity in senescent cells. in Cancer research 2006
Show all 4 references for ABIN197028
Human Polyclonal NF2 Primary Antibody for IHC, ELISA - ABIN1532019
Yu, Zeidel, Hill: Cellular expression profile for interstitial cells of cajal in bladder - a cell often misidentified as myocyte or myofibroblast. in PLoS ONE 2012
Show all 3 references for ABIN1532019
Human Polyclonal NF2 Primary Antibody for EIA, WB - ABIN117953
Gutmann, Wright, Geist, Snider: Expression of the neurofibromatosis 2 (NF2) gene isoforms during rat embryonic development. in Human molecular genetics 1995
Show all 2 references for ABIN117953
Human Polyclonal NF2 Primary Antibody for IP, IHC - ABIN104130
Wang, Lu, Tang, Wang, Wu: The phosphorylation status of merlin in sporadic vestibular Schwannomas. in Molecular and cellular biochemistry 2009
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Human Polyclonal NF2 Primary Antibody for ELISA, WB - ABIN1533058
Trofatter, MacCollin, Rutter, Murrell, Duyao, Parry, Eldridge, Kley, Menon, Pulaski: A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor. in Cell 1993
Show all 2 references for ABIN1533058
Zebrafish (Danio rerio) Polyclonal NF2 Primary Antibody for EIA, IHC (p) - ABIN401528
Sadler, Amsterdam, Soroka, Boyer, Hopkins: A genetic screen in zebrafish identifies the mutants vps18, nf2 and foie gras as models of liver disease. in Development (Cambridge, England) 2005
Human Polyclonal NF2 Primary Antibody for EIA, WB - ABIN453191
James, Han, Polizzano, Plotkin, Manning, Stemmer-Rachamimov, Gusella, Ramesh: NF2/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growth. in Molecular and cellular biology 2009
Mutation of nf2 gene develops extrahepatic choledochal cysts in the common bile duct
loss of axonal contact following nerve injury results in merlin phosphorylation leading to increased p75(NTR (show NGFR Antibodies)) expression.
Loss of Nf2 and Cdkn2a (show CDKN2A Antibodies)/b have synergistic effects with PDGF-B (show PDGFB Antibodies) overexpression promoting meningioma malignant transformation.
Merlin 1 and 2 act as tumor suppressors and are required for optimal sperm maturation
Together our results uncover miRNAs as yet another negative mechanism controlling Merlin tumor suppressor functions.
Merlin and Ezrin (show EZR Antibodies) are components of a mechanism where mechanical forces associated with cell junctions are transduced across the cell cortex via cortical actomyosin cytoskeleton to control lateral mobility and activity of epidermal growth factor receptor (show EGFR Antibodies).
The study describe a novel NF2 mouse model recapitulating schwannoma phenotypes found in human patients where tumors develop in the cranial nerve VIII (show COX8A Antibodies) and/or the spinal roots.
Nf2/Merlin controls spinal cord neural progenitor function in a Rac1/ErbB2 (show ERBB2 Antibodies)-dependent manner.
Nf2-Yap signaling plays important roles in controlling the expansion of dorsal root ganglia progenitors and glia during DRG development
CD44 (show CD44 Antibodies) cytoplasmic tail cleaved by RIP (show HRB Antibodies) could release DCAF1 (show VPRBP Antibodies) from merlin by competing for binding to the merlin FERM domain, which results in the inhibition of merlin-mediated suppression of tumorigenesis.
Findings indicate that merlin is sumoylated and that this post-translational modification is essential for tumor suppression.
Data suggest that, at least using the commercial antibodies used in this study, immunohistochemical staining for NF2 (neurofibromin 2), LATS2 (show LATS2 Antibodies) (large tumor suppressor (show LATS1 Antibodies) kinase 2), and YAP (show YAP1 Antibodies)/TAZ (show TAZ Antibodies) (nuclear translocation of complex of Yes-associated protein [YAP (show YAP1 Antibodies)] with transcriptional coactivator with PDZ-binding motif (show WWTR1 Antibodies) [TAZ (show TAZ Antibodies)]) is not helpful for differential diagnosis of mesothelioma versus a benign proliferation.
The mortality of patients with NF2 diagnosed in more recent decades was lower than that of patients diagnosed earlier.
AMOTL1 (show AMOTL1 Antibodies) Promotes Breast Cancer Progression and Is Antagonized by Merlin
homozygous deletions in CDKN2A (show CDKN2A Antibodies) and hemizygous loss of NF2 as detected by fluorescence in situ hybridization would confer a poor clinical outcome and may guide future treatment decisions for patients with peritoneal mesothelioma.
NF2/merlin inactivation augments mutant RAS signaling by promoting YAP (show YAP1 Antibodies)/TEAD-driven transcription of oncogenic and wild-type RAS, resulting in greater MAPK (show MAPK1 Antibodies) output and increased sensitivity to MEK (show MAP2K1 Antibodies) inhibitors.
we demonstrate that NF2 negatively controls the invasiveness of Glioblastoma multiforme through YAP (show YAP1 Antibodies)-dependent induction of CYR61/CCN1 (show CYR61 Antibodies) and miR (show MLXIP Antibodies)-296-3p.
angiomotin and Merlin respectively interface cortical actin filaments and core kinases in Hippo signaling
(Delta2-4)Merlin variant disrupts the normal function of Merlin and promotes hepatocellular carcinoma metastasis.
Stusies indicate that monosomy 22, which is often associated with mutations of the neurofibromin 2 (NF2) gene, has emerged as the most frequent alteration of meningiomas.
This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development\; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.
neurofibromin 2 (bilateral acoustic neuroma)
, neurofibromatosis 2
, neurofibromin 2
, moesin-ezrin-radixin-like protein
, moesin-ezrin-radixin like
, moesin-ezrin-radizin-like protein