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Neurogranin Proteins (NRGN)

Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. Additionally we are shipping Neurogranin Antibodies (46) and Neurogranin Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NRGN 64011 P60761
Rat NRGN NRGN 64356 Q04940
NRGN 4900 Q92686
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Top Neurogranin Proteins at

Showing 8 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Serinus canaria His tag   1 mg Log in to see 56 to 66 Days
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
Yeast Goat His tag   1 mg Log in to see 56 to 66 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

NRGN Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,

Top referenced Neurogranin Proteins

  1. Human Neurogranin Protein expressed in Wheat germ - ABIN1313028 : Skelding, Suzuki, Gordon, Xue, Verrills, Dickson, Rostas: Regulation of CaMKII by phospho-Thr253 or phospho-Thr286 sensitive targeting alters cellular function. in Cellular signalling 2010 (PubMed)

More Proteins for Neurogranin (NRGN) Interaction Partners

Mouse (Murine) Neurogranin (NRGN) interaction partners

  1. The results of this study indicated that elevated neurogranin function within the PFC (show CFP Proteins) can enhance local plasticity and increase the rate of extinction learning across different behavioral tasks.

  2. Neurogranin knockout mice are hyperactive and socially withdrawn.

  3. findings suggest that mobilization of CaM (show Calm2 Proteins) and Ng to stimulated dendritic spines may enhance synaptic efficacy by increasing and prolonging the Ca2 (show CA2 Proteins)+ transients and activation of Ca2 (show CA2 Proteins)+/CaM (show Calm2 Proteins)-dependent enzymes.

  4. We propose that the differential regulation of multiple sense and novel overlapping natural antisense transcripts at the Nrgn and Camk2n1 (show CAMK2N1 Proteins) loci will increase the diversity of posttranscriptional regulation

  5. Results provide a new specific neurochemical marker to identify a subpopulation of olfactory granule cells and suggest possible functional implications for neurogranin in olfactory bulb plasticity mechanisms.

  6. Attenuation of protein kinase C and cAMP-dependent protein kinase (show CDK7 Proteins) signal transduction in the neurogranin knockout mouse

  7. Neurogranin expression in the cerebellum by brush cells, which are excitatory, shows remarkable cell type- and species-specific expression patterns of a postsynaptic protein mediating calcium signaling mechanisms.

  8. calcium dynamics are altered in cortical neurons lacking the calmodulin-binding protein RC3

  9. NMDA induced a rapid and transient phosphorylation and oxidation of neurogranin in mouse hippocampal slices

  10. NG is expressed by principal cells in different neocortical layers and in the hippocampus by granule cells of the dentate gyrus and pyramidal neurons of CA1 (show CA1 Proteins)-CA3 (show CA3 Proteins).

Human Neurogranin (NRGN) interaction partners

  1. Polymorphisms in NRGN are associated with schizophrenia, major depressive disorder and bipolar disorder in the Han Chinese population.

  2. Neurogranin and YKL-40 (show CHI3L1 Proteins) are promising AD biomarkers, independent of and complementary to the established core Alzheimer's disease (AD) biomarkers, reflecting additional pathological changes in the course of AD

  3. These results confirm an increase in CSF (show CSF2 Proteins) Ng concentration in patients with AD as previously reported and show that this is specific to AD and not seen in a range of other neurodegenerative diseases.

  4. This report provides evidence to support larger and controlled traumatic brain injury clinical studies for NRGN validation and prediction of outcomes.

  5. Within-person levels of NGRN (show NGRN Proteins) increased in cognitively normal participants but not in patients with later stage mild cognitive impairment or Alzhiemer's disease; NGRN (show NGRN Proteins) may reflect presymptomatic synaptic dysfunction or loss.

  6. Cerebrospinal fluid neurogranin was increased in patients with Alzheimer's dementia, progressive mild cognitive impairment (MCI (show MCIN Proteins)) and stable MCI (show MCIN Proteins) compared with controls, and in Alzheimer's dementia and progressive MCI (show MCIN Proteins) compared with stable MCI (show MCIN Proteins).

  7. neurogranin binds to alpha-synuclein in the human cortex, and this interaction decreases in Parkinson's disease along with the phosphorylation of neurogranin, a molecular process thought to be involved in learning and memory

  8. These findings help to clarify underlying NRGN mediated pathophysiological mechanisms involving cortical-subcortical brain networks in schizophrenia.

  9. Data indicate that neurogranin makes contacts with both the N- and C-domains of calmodulin (show CALM1 Proteins) that functionally leads to altered calcium binding kinetics.

  10. NRGN risk variants contribute to subtle changes in neural functioning and anatomy.

Cow (Bovine) Neurogranin (NRGN) interaction partners

  1. interaction of Ca(2 (show CA2 Proteins)+)-free calmodulin (show KRIT1 Proteins) (apoCaM) with the IQ motif corresponding to the calmodulin (show KRIT1 Proteins)-binding domain of neurogranin has been studied by nuclear magnetic resonance (NMR) methods

Neurogranin (NRGN) Protein Profile

Protein Summary

Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects.

Gene names and symbols associated with Neurogranin Proteins (NRGN)

  • neurogranin (Nrgn)
  • neurogranin (protein kinase C substrate, RC3) (NRGN)
  • 0710001B06Rik protein
  • AI838505 protein
  • hng protein
  • NG protein
  • NG/RC3 protein
  • Pss1 protein
  • R75334 protein
  • RC3 protein

Protein level used designations for Neurogranin Proteins (NRGN)

neurogranin (protein kinase C substrate, RC3) , postsynaptic spine 1 , protein kinase C substrate , ng , protein kinase C substrate 7.5 kDa protein , calmodulin-binding protein , neurogranin , B-50 immunoreactive C-kinase substrate , BICKS , NG , p17 , protein kinase C substrate, RC3

64011 Mus musculus
64356 Rattus norvegicus
4900 Homo sapiens
479401 Canis lupus familiaris
616955 Bos taurus
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