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NAV3 belongs to the neuron navigator family and is expressed predominantly in the nervous system.
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Together, our findings suggest an important role for miR (show MLXIP Antibodies)-21 in the progression of HCC (show FAM126A Antibodies), which negatively regulated Navigator-3 in the migration of HCC (show FAM126A Antibodies).
The authers propose that NAV3 inhibits breast cancer progression by regulating microtubule dynamics, biasing directionally persistent rather than random migration, and inhibiting locomotion of initiated cells.
Data indicate that neuron navigator 3 (NAV3) may be a potential new prognostic biomarker and a potential therapeutic target.
NAV3 has a role in linking tissue inflammation to cancer development in the colon.
characterized copy number changes of NAV3 in 24 basal cell cancers, eight squamous cell cancers and eight non-malignant inflammatory skin lesions
NAV3 gene would not be frequently deleted in cutaneous type leukemia/lymphoma including those with mycosis fungoides-like manifestations
Allelic NAV3 aberrations (LOH or deletion by FISH were identified in 44% of the subcutaneous panniculitis-like T-cell lymphoma samples.
An imbalanced fluorescence in situ hybridization pattern between NAV3 and pericentromeric control probes was seen in three patients in accordance with CGH array data. No NAV3 specific breakpoint or partial deletion was detected.
This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. Multiple alternatively spliced transcript variants for this gene have been described but only one has had its full-length nature determined.
neuron navigator 3
, pore membrane and/or filament interacting like protein 1
, pore membrane and/or filament-interacting-like protein 1
, steerin 3
, unc-53 homolog 3