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NCF2 encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. Additionally we are shipping NCF2 Proteins (12) and many more products for this protein.
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Human Monoclonal NCF2 Primary Antibody for IF, WB - ABIN968245
Ago, Nunoi, Ito, Sumimoto: Mechanism for phosphorylation-induced activation of the phagocyte NADPH oxidase protein p47(phox). Triple replacement of serines 303, 304, and 328 with aspartates disrupts the SH3 domain-mediated intramolecular interaction in p47(phox), thereby activating in The Journal of biological chemistry 1999
Show all 5 references for 968245
Human Polyclonal NCF2 Primary Antibody for ICC, IF - ABIN4343179
Lomnytska, Becker, Bodin, Olsson, Hellman, Hellström, Mints, Hellman, Auer, Andersson: Differential expression of ANXA6, HSP27, PRDX2, NCF2, and TPM4 during uterine cervix carcinogenesis: diagnostic and prognostic value. in British journal of cancer 2011
analysis of NCF2, BCKDHB (show BCKDHB Antibodies) and BCKDHA (show BCKDHA Antibodies) in pig
Phosphoinositol 3-phosphate regulates reactive oxygen species production by maintaining p40phox (show NCF4 Antibodies) and p67phox at the phagosomal membrane.
TLR4 (show TLR4 Antibodies)- and TLR2 (show TLR2 Antibodies)-induced IRAK (show IRAK1 Antibodies)-ERK (show EPHB2 Antibodies) pathway cross-talks with p67phox-Nox-2 (show CYBB Antibodies) for reactive oxygen species generation, thus regulating IL-1beta (show IL1B Antibodies) transcription and processing in monocytic cells.
Skeletal muscle protein expression of the NADPH oxidase (show NOX1 Antibodies) subunits p22(phox (show CYBA Antibodies)), p47(phox), and p67(phox) was increased in obese relative to lean subjects, where p22(phox (show CYBA Antibodies)) and p67(phox) expression was attenuated by exercise training in obese subjects.
A novel homozygous mutation in NCF2.
results reveal an essential role for the Cys (show DNAJC5 Antibodies)-Gly-Cys (show DNAJC5 Antibodies) triad in Nox2 (show CYBB Antibodies) in binding p67(phox), seconded by an additional binding region, comprising residues C terminal to Cys (show DNAJC5 Antibodies)-Gly-Cys (show DNAJC5 Antibodies). The 2 regions interact with distinct partner sites in p67(phox).
This model assigns a central role to Arg-395 in the structure and stability of the quaternary NCF2/NCF4 (show NCF4 Antibodies)/VAV1 (show VAV1 Antibodies)/RAC1 NADPH oxidase (show NOX1 Antibodies) complex.
Data indicate that arachidonic acid induces the direct interaction of Rac (show AKT1 Antibodies)-GTP (show AK3 Antibodies)-bound p67(phox) with the C-terminal cytosolic region of phagocyte NADPH oxidase (show NOX1 Antibodies) Nox2 (show CYBB Antibodies).
Four novel mutations in the NCF1 (show NCF1 Antibodies), NCF2, and CYBB (show CYBB Antibodies) genees have been identified in chronic granulomatous disease patients in Morocco.
Results not only establish allelic heterogeneity within NCF2 associated with SLE, but also emphasize the utility of multi-ethnic cohorts to identify predisposing variants explaining additional phenotypic variance of complex diseases like SLE.
NCF2 in Asian populations shows a pattern of diversity characterized by a differentiated haplotype structure.
Just as patients with chronic granulomatous disease who lack NADPH oxidase (show NOX1 Antibodies) rarely develop SLE, NCF-2-null mice on a nonautoimmune background were susceptible to a chronic granulomatous disease-like opportunistic infection but did not develop lupus. In contrast, on a lupus-prone background, even haploinsufficiency of NCF-2 accelerated the development of full-blown lupus disease.
p67(phox) binds to phosphoPrdx6 and inhibits its PLA2 (show PLA2G2A Antibodies) activity, an interaction that could function to terminate the PLA2 (show PLA2G2A Antibodies)-mediated NOX2 (show CYBB Antibodies) activation signal.
The results of this study suggested that repeated stress promotes depressive behavior through the upregulation of NADPH (show FDXR Antibodies) oxidasesubunit (67kDa (show RPSA Antibodies)) and the resultant metabolic oxidative stress.
Data suggest that a cytosolic source of reactive oxygen species, probably p67(phox) subunit of cardiac NADPH oxidase 2 (NOX2 (show CYBB Antibodies)), may contribute to the hypertrophic phenotype in glucose transporter 4 gene (GLUT4 (show SLC2A4 Antibodies)-/-) mice.
This report evaluates neutrophil cytosolic factor 2 (Ncf2) as a candidate Salmonella susceptibility gene for Ity3.
This study demonstrates the involvement of ROS (show ROS1 Antibodies) from NADPH oxidase (show NOX1 Antibodies) in mediating paraquat cytotoxicity in BV-2 microglial cells and this process is mediated through PKCdelta (show PKCd Antibodies)- and ERK (show EPHB2 Antibodies)-dependent pathways.
This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms.
neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2)
, neutrophil cytosolic factor 2
, neutrophil cytosol factor 2
, predicted neutrophil cytosolic factor 2
, NADPH oxidase cytosolic protein p67phox
, NADPH oxidase cytosolic protein
, 67 kDa neutrophil oxidase factor
, NADPH oxidase activator 2
, chronic granulomatous disease, autosomal 2
, neutrophil NADPH oxidase factor 2
, neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2)
, NADPH oxidase subunit (67 kD)
, NADPH oxidase subunit (67kDa)