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NASP encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Additionally we are shipping Nuclear Autoantigenic Sperm Protein (Histone-Binding) Proteins (7) and Nuclear Autoantigenic Sperm Protein (Histone-Binding) Kits (4) and many more products for this protein.
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Cow (Bovine) Polyclonal NASP Primary Antibody for IHC, WB - ABIN2787368
Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in Molecular systems biology 2007
findings reveal a new mode of interaction between a TPR repeat domain of histone chaperone sNASP and an evolutionarily conserved peptide motif found in canonical H3 and in all histone H3 (show HIST3H3 Antibodies) variants
Our research demonstrates that knockdown of tNASP effectively inhibits the proliferation and causes G1 phase arrest through ERK/MAPK (show MAPK1 Antibodies) signal pathway.
NASP family Proteins are highly conserved throughout the eukaryotes and posses four TPR motifs. It was likely present in the last common ancestor of eukaryotes possibly representing an important innovation regarding H3/H4 transport mechanism. Different TPR motifs in NASP have evolved at different rates with TPR1/4 evolving faster than TPR2 (show DNAJC7 Antibodies)/3.
Studies indicate that histone chalerones nucleoplasmin (show NPM1 Antibodies) (NPM2 (show NPM2 Antibodies)/NPM3 (show NPM3 Antibodies)) preferentially associated with histones H2A-H2B in the egg and the nuclear autoantigenic sperm protein (NASP) families.
an increase of miR (show MLXIP Antibodies)-29a, and hence decrease of Nasp, may contribute to inhibit cell proliferation during postnatal organ development.
The insights into NASP function and the existence of a tunable reservoir in mammalian cells demonstrate that contingency is integrated into the histone supply chain to respond to unexpected changes in demand.
NASP and RCAS1 (show EBAG9 Antibodies) proteins were more frequently expressed in ovarian cancer tissues than with normal ovarian tissue and serous cystadenomas and MRE11 (show MRE11A Antibodies) was less frequently expressed
NASP and the linker histones are key players in the assembly of chromatin after DNA replication
NASP forms distinct, high specificity complexes with histones H3 and H4.
NASP belongs to a network of genes and gene functions that are critical for cell survival
NASP controls the ability of HSPA2 (show HSPA2 Antibodies) to activate CDC2 (show CDK1 Antibodies) for CDC2 (show CDK1 Antibodies)/cyclin B1 (show CCNB1 Antibodies) complex formation; therefore, tNASP's role is to provide the functional link between linker histones and cell cycle progression during meiosis.
in the cytoplasm linker histones are bound to a complex containing NASP and HSP90 (show HSP90 Antibodies) whose ATPase (show DNAH8 Antibodies) activity is stimulated by binding NASP
Sp1 (show SP1 Antibodies) and Ets (show ETS1 Antibodies) are the primary activators of the NASP promoter.
NASP mRNA expression is required for preimplantation development (show MTA2 Antibodies) into the blastocyst stage in cattle.
This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa.
nuclear autoantigenic sperm protein (histone-binding)
, histone H1-binding protein
, nuclear autoantigenic sperm protein
, somatic histone binding protein NASP