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Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Additionally we are shipping NFE2 Antibodies (40) and many more products for this protein.
Showing 6 out of 7 products:
NF-E2, TAL1 and KLF1, all activators play a primary role in HSs formation in the LCR
under the obese condition, activation of the hepatic NFE2/miR (show MLXIP Proteins)-423-5p axis plays important roles in the progression of type 2 diabetes and NAFLD by repressing the FAM3A (show FAM3A Proteins)-ATP-Akt (show AKT1 Proteins) signaling pathway.
Our data presented herein support the hypothesis that cytoplasmically located NF-E2 may have a function in the elimination of internal organelles. The mild autophagy defect observed in our mice may be due to the requirement for additional proteins in the formation of larger complexes to exert this function.
assessment of NF-E2 and NGFR (show NGFR Proteins) expression may provide additional support in reaching a correct diagnosis in discriminating polycythemia vera (show IGF2BP3 Proteins) from prefibrotic/fibrotic primary myelofibrosis and essential thrombocythemia
The genes BCL6, NFE2, POU4F2 and ELF4 are primary 1,25(OH)2D3 targets in THP-1 cells
the RUNX1 (show RUNX1 Proteins) target NF-E2 is part of the molecular network by which RUNX1 (show RUNX1 Proteins) regulates platelet biogenesis and function in a pedigree with familial platelet disorder with a predisposition to acute myelogenous leukemia
A functional link among the erythroid transcription factors GATA-1 (show GATA1 Proteins)/NF-E2, miR (show MLXIP Proteins)-199b-5p in erythropoiesis.
NF-E2 immunohistochemistry and analysis of the proportion of nuclear positive erythroblasts of all erythroid precursor cells can help to distinguish between ET and PMF (show PRB1 Proteins) even in early stages of the diseases.
NFE-2 transgene mediates the expression of interleukin 8 (show IL8 Proteins) in myeloproliferative neoplasms, thereby contributing to myeloproliferative neoplasm pathology.
Findings suggest a model whereby ROCK inhibition drives polyploidization, DMS growth and proplatelet formation late in megakaryocyte maturation through downregulation of MYC (show MYC Proteins) and NFE2 expression.
Under the obese condition, activation of the hepatic NFE2/miR (show MLXIP Proteins)-423-5p axis plays important roles in the progression of type 2 diabetes and NAFLD by repressing the FAM3A (show FAM3A Proteins)-ATP-Akt (show AKT1 Proteins) signaling pathway.
results suggest that Nrf2 (show NFE2L2 Proteins) deficiency induced by HFD promoted hepatic fatty acid metabolism disorder by altering 18-carbon and 22-carbon fatty acid composition
A novel murine model may excellently describe the deleterious impact of sustained chronic NF-E2 overexpression during uncontrolled chronic inflammation upon the hematopoietic system--the development of clonal myeloproliferation.
Although none of the parameters measured were different between the NF-E2 deficient and control mice, an increase in calcium (21%) and an increase in the mineral/matrix ratio (32%) was observed in GATA-1 (show GATA1 Proteins) deficient mice.
By activating genes in megakaryocytes that mediate platelet production and function, NF-E2 p45 determines the quantity and quality of platelets.
maintaining expression of intestinal epithelial cell prohibitin (show PHB Proteins) reduces the severity of inflammation and increases colonic levels of the antioxidants HO-1 (show HMOX1 Proteins) and NQO-1 (show NQO1 Proteins) via a mechanism independent of Nfe2
These findings demonstrate that a combination of p45NF-E2, Maf (show MAF Proteins) G, and Maf (show MAF Proteins) K is a key determinant of both megakaryopoiesis and thrombopoiesis.
Loss of p45 NF-E2 leads to a 2-fold increase in serum erythropoietin (show EPO Proteins) & increased splenic erythropoiesis. Erythroid cells were arrested at the G(1) stage of cell cycle.
Nfe2 modulates JunD (show JUND Proteins) binding to the Gcm1 (show GCM1 Proteins) promoter via acetylation
studies identify a novel function of p45NF-E2 during placental development: in trophoblast cells, p45NF-E2 represses Gcm1 (show GCM1 Proteins) and syncytiotrophoblast formation via acetylation
Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.
leucine zipper protein NF-E2
, nuclear factor, erythroid derived 2
, nuclear factor, erythroid-derived 2 45 kDa subunit
, p45 NF-E2
, transcription factor NF-E2 45 kDa subunit
, nuclear factor (erythroid-derived 2), 45kD
, nuclear factor (erythroid-derived 2), 45kDa
, nuclear factor, erythroid derived 2, 45 kDa