Nuclear Factor I/B Proteins (NFIB)

Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. Additionally we are shipping NFIB Antibodies (53) and NFIB Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NFIB 4781 O00712
NFIB 18028 P97863
Rat NFIB NFIB 29227  
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Top NFIB Proteins at

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
HOST_Escherichia coli (E. coli) Human S tag,His tag   100 μg Log in to see 15 to 18 Days

NFIB Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine)

More Proteins for Nuclear Factor I/B (NFIB) Interaction Partners

Human Nuclear Factor I/B (NFIB) interaction partners

  1. low expression of NFIB was significantly associated with biologically more aggressive subtypes and, ultimately, poorer survival in lung adenocarcinoma patients

  2. Data indicate that NFIB protein increases EZH2 (show EZH2 Proteins) protein expression downstream of BRN2 (show POU3F2 Proteins) protein, which further decreases MITF (show MITF Proteins) protein levels.

  3. Our study defines new molecular subclasses of ACC characterized by MYBL1 (show MYBL1 Proteins) rearrangements and 5'-NFIB gene fusions.

  4. In benign prostatic hyperplasia, luminal NFIB loss correlated with more severe disease. in androgen-dependent LNCaP prostate cancer cells demonstrated that 64.3% of NFIB binding sites are associated with AR and FOXA1 binding sites.

  5. These data suggest that germline genetic variation at rs7034162 is important in osteosarcoma metastasis and that NFIB is an osteosarcoma metastasis susceptibility gene.

  6. Further studies also discovered a conserved feedback regulatory circuitry formed by NFIB and miR (show MLXIP Proteins)-365 in cutaneous squamous cell carcinoma development

  7. multivariate analysis co-overexpression of NFIB, RANK and RANKL (show TNFSF11 Proteins) significantly increased the risk of metastasis with an odds ratio of 13.59

  8. TGF-beta (show TGFB1 Proteins)-mediated suppression of ANT2 (show SLC25A5 Proteins) through NF1 (show NF1 Proteins)/Smad4 (show SMAD4 Proteins) complexes contributes to oxidative stress and DNA damage during induction of cellular senescence.

  9. Increased expression of NF1B is associated with pilocytic astrocytoma.

  10. The data demonstrates that the autism spectrum disorder-associated A-C intronic haplotype of the ENGRAILED2 gene is a transcriptional activator, and both CUX1 (show CUX1 Proteins) and NFIB mediate this activity.

Mouse (Murine) Nuclear Factor I/B (NFIB) interaction partners

  1. Loss of Nfib resulted in a severe delay in intermediate progenitor cell generation while, conversely, overexpression of NFIX (show MLZE Proteins) led to precocious intermediate progenitor cell generation.

  2. Knockdown of NFIB in Drosha (show DROSHA Proteins)-deficient hippocampal neural stem cells restores neurogenesis, suggesting that the Drosha (show DROSHA Proteins)/NFIB mechanism robustly prevents oligodendrocyte fate acquisition in vivo.

  3. Nfib is necessary and sufficient to increase chromatin accessibility at a large subset of the intergenic regions. Nfib promotes pro-metastatic neuronal gene expression programs and drives the metastatic ability of small cell lung cancer cells.

  4. Loss of Nfib expression resulted in prostatic hyperplasia. NFIB knockdown studies demonstrated that loss of NFIB drives increased AR expression and superinduction of a subset of AR target genes.

  5. Identify regulatory link between Nkx2-1 (show NKX2-1 Proteins), miR (show MLXIP Proteins)-200c, and the transcription factors Nfib and Myb (show MYB Proteins), adding new players to the regulatory mechanisms driven by Nkx2-1 (show NKX2-1 Proteins) in lung epithelial cells that may have implications in lung development and tumorigenesis.

  6. NFIA (show NFIA Proteins) and NFIB are endogenously expressed in gradients with high caudo-medial to low rostro-lateral expression ... this expression pattern deviates from that of PAX6 (show PAX6 Proteins), suggesting that PAX6 (show PAX6 Proteins) does not drive Nfi (show NFIC Proteins) expression

  7. NFIB-STAT5 (show STAT5A Proteins) modules, possibly in conjunction with other transcription factors, control cell-specific genetic programs.

  8. Study revealed both novel and broad functions of NFIB in regulating the generation of cortical projection neurons, including radial glial differentiation, neuronal migration and axon projection

  9. downregulation of Ezh2 (show EZH2 Proteins) transcription by NFIB is an important component of the process of neural progenitor cell differentiation during cortical development

  10. transcription factor NFIB is an unanticipated coordinator of stem cell behaviour

NFIB Protein Profile

Protein Summary

Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

Gene names and symbols associated with Nuclear Factor I/B Proteins (NFIB)

  • nuclear factor I/B (NFIB)
  • nuclear factor I/B (LOC100221557)
  • nuclear factor I/B (LOC100340884)
  • nuclear factor I/B (nfib)
  • nuclear factor I/B (Nfib)
  • 6720429L07Rik protein
  • CTF protein
  • E030026I10Rik protein
  • HMGIC/NFIB protein
  • NF-I/B protein
  • NF1-B protein
  • nf1-b1 protein
  • NFI-B protein
  • NFI-RED protein
  • NFIB protein
  • NFIB2 protein
  • NFIB3 protein

Protein level used designations for Nuclear Factor I/B Proteins (NFIB)

nuclear factor I/B , nuclear factor 1 B-type-like , nuclear factor I-B1 , CCAAT-box binding transcription factor , CCAAT-box-binding transcription factor , CTF , NF-I/B , NF1-B , NFI-B , TGGCA-binding protein , nuclear factor 1 B-type , nuclear factor 1/B , olfactory epithelium nuclear factor I-B

714098 Macaca mulatta
100221557 Taeniopygia guttata
100340884 Oryctolagus cuniculus
100397451 Callithrix jacchus
734209 Xenopus laevis
396209 Gallus gallus
4781 Homo sapiens
474709 Canis lupus familiaris
538474 Bos taurus
18028 Mus musculus
29227 Rattus norvegicus
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