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NRF1 encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial D. Additionally we are shipping Nuclear Respiratory Factor 1 Kits (10) and Nuclear Respiratory Factor 1 Proteins (6) and many more products for this protein.
Showing 10 out of 93 products:
Chicken Polyclonal NRF1 Primary Antibody for EIA, IHC (p) - ABIN401025
Mootha, Bunkenborg, Olsen, Hjerrild, Wisniewski, Stahl, Bolouri, Ray, Sihag, Kamal, Patterson, Lander, Mann: Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. in Cell 2003
Show all 6 references for ABIN401025
Human Polyclonal NRF1 Primary Antibody for IF (p), IHC (p) - ABIN675219
Qin, Wang, Huo, Yan, Jiang, Zhou, Wang, Sang: Sulfur dioxide inhalation stimulated mitochondrial biogenesis in rat brains. in Toxicology 2012
Show all 2 references for ABIN675219
Human Polyclonal NRF1 Primary Antibody for IHC, WB - ABIN2780636
Yang, Zhao, Lue, Li, Du, Ning, Lu, Ke: KIAA0649, a 1A6/DRIM-interacting protein with the oncogenic potential. in Biochemical and biophysical research communications 2005
Show all 2 references for ABIN2780636
Human Monoclonal NRF1 Primary Antibody for IHC (p), RNAi - ABIN2752368
Thompson, MacDonald, Mueller: Decreased expression of BRCA1 in SK-BR-3 cells is the result of aberrant activation of the GABP Beta promoter by an NRF-1-containing complex. in Molecular cancer 2011
Chicken Polyclonal NRF1 Primary Antibody for WB - ABIN2780635
Ramachandran, Yu, Gulick: Nuclear respiratory factor 1 controls myocyte enhancer factor 2A transcription to provide a mechanism for coordinate expression of respiratory chain subunits. in The Journal of biological chemistry 2008
NRF1 (nuclear respiratory factor 1) is a methylation-sensitive transcription factor; in the absence of DNA methylation (show HELLS Antibodies), NRF1 binds to new sites and induces aberrant transcription
Nrf1 plays critical roles in regulating glucose metabolism, mitochondrial function, and insulin (show INS Antibodies) secretion, suggesting that Nrf1 may be a novel target to improve the function of insulin (show INS Antibodies)-secreting beta-cells.
Nrf1 is negatively regulated by its O-GlcNAcylation status that depends on the glucose concentrations
lysine-specific demethylase (show MBD2 Antibodies) 1 promotes oxidative phosphorylation in white adipose tissue, in cooperation with Nrf1.
Results show that Nrf1 may not be directly responsible for (show GCLC Antibodies) the loss (show GCLM Antibodies) of Nrf2-dependent inducibility of a (show HBe1 Antibodies)ntioxidant and cytoprotective genes observed in aged animals.
Denervation induced proteasomal activation via NFE2L1 (show NFE2L1 Antibodies) nuclear translocation in control mice
Nrf1 controls both the fatty acid and the cystine/cysteine content of hepatocytes by participating in an elaborate regulatory network.
During fetal myogenesis, Pitx2 (show PITX2 Antibodies)/3 control this redox state through the regulation of Nrf1 and of antioxidant pathways.
This stduy identify the bZIP transcription factor Nfe2l1 (show NFE2L1 Antibodies) and demonstrate that it promotes glial fate under direct Sox9 (show SOX9 Antibodies) regulatory control.
The study identifies casein kinase 2 as an NRF1-binding protein and finds that the knockdown of casein kinase 2 enhances the Nrf1-dependent expression of the proteasome subunit genes.
Importantly, Nrf1 activity is positively and/or negatively regulated by distinct doses of proteasome and calpain inhibitors
Low NRF1 (show NFE2L1 Antibodies) expression was associated lymphatic metastasis and radio-resistance in nasopharyngeal carcinoma.
EglN2 (show EGLN2 Antibodies) associates with the NRF1 (show NFE2L1 Antibodies)-PGC1alpha complex and controls mitochondrial function in breast cancer
Lack of aprataxin (show APTX Antibodies) impairs mitochondrial functions via downregulation of the APE1 (show APEX1 Antibodies)/NRF1 (show NFE2L1 Antibodies)/NRF2 (show GABPA Antibodies) pathway.
We show that composite nucleosomes containing mH2A and NRF-1 (show NFE2L1 Antibodies) are stably positioned on gene regulatory regions and can buffer transcriptional noise associated with antiviral responses
This review outlines Nrf1 (show NFE2L1 Antibodies) structure, function, regulation and its links to insulin (show INS Antibodies) resistance, diabetes and inflammation.
Results present evidence in the support of E2-induced ROS (show ROS1 Antibodies)-mediated AKT (show AKT1 Antibodies) signalling leading to the activation of NRF-1 (show NFE2L1 Antibodies)-regulated cell cycle genes.
The treatment with E2, Res, or VC significantly increased mRNA and protein expression levels of Nrf1 (show NFE2L1 Antibodies).
Nrf1 (show NFE2L1 Antibodies) knockout resulted in the increased expression of GCLC (show GCLC Antibodies) and GCLM (show GCLM Antibodies) in human bronchial epithelial (HBE1 (show HBe1 Antibodies)) cells.
This study identified a regulatory branch of the mitochondrial unfolded protein response (UPR(mt)), which is mediated by the interplay of SIRT7 (show SIRT7 Antibodies) and NRF1 (show NFE2L1 Antibodies) and is coupled to cellular energy metabolism and proliferation.
Transcription Factor A (show GTF3A Antibodies) expression associated with mitochondrial biogenesis activation & high levels of NRF1 mRNA from oocyte stage onwards argue for essential function of these factors during 1st steps of bovine embryogenesis
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for 'nuclear factor (erythroid-derived 2)-like 1' which has an official symbol of NFE2L1.
nuclear respiratory factor 1
, nuclear respiratory factor-1
, NF-E2-related factor 1
, NFE2-related factor 1
, nuclear factor erythroid 2-related factor 1
, alpha palindromic-binding protein
, not really finished protein
, transcription factor