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May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in degenerating rods (By similarity). Additionally we are shipping NXNL1 Proteins (7) and and many more products for this protein.
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Study shows that RdCVF acts through binding to Basigin-1 (BSG1 (show ZBTB24 Antibodies)), a transmembrane protein expressed specifically by photoreceptors. BSG1 (show ZBTB24 Antibodies) binds to the glucose transporter GLUT1 (show SLC2A1 Antibodies), resulting in increased glucose entry into cones.
Data suggest a critical role for TXNL6 in MsrA (show MSRA Antibodies) repair of essential lens proteins under oxidative stress conditions and that TXNL6 is important for MsrA (show MSRA Antibodies) defense protection against cataract.
regulation of the Nucleoredoxin (show NXN Antibodies)-like genes involves a CRX (show CRX Antibodies) responsive element that can act as both as a positive regulator of promoter activity and as a modulator of cell-type specificity
CHX10 (show VSX2 Antibodies) regulates RdCVF promoter activity in the inner retina.
is a truncated thioredoxin-like (show TXN Antibodies) protein specifically expressed by photoreceptors. The identification of this protein offers new treatment possibilities for retinitis pigmentosa
RdCVF variants have roles in leber congenital amaurosis
TXNL6 probably protects retinal cells from photooxidative damage-induced apoptosis via upregulation of NF-kappaB (show NFKB1 Antibodies) activity
The Nxnl1 gene, through the thioredoxin (show TXN Antibodies) RdCVF-long isoform, is part of an endogenous defense mechanism against photooxidative stress.
The RdCVF gene has an essential role in photoreceptor maintenance and resistance to retinal oxidative stress.
May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in degenerating rods (By similarity).
nucleoredoxin-like protein 1
, rod-derived cone viability factor
, thioredoxin-like 6
, thioredoxin-like protein 6