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Mediates the hydrolysis of some nucleoside diphosphate derivatives. Additionally we are shipping NUDT15 Antibodies (25) and many more products for this protein.
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Thiopurine treatment should not be recommended to patients with NUDT15 homozygous variant genotype due to severe early leukopenia
All patients with both NUDT15 rs116855232 heterozygous variants and ABCC4 (show ABCC4 Proteins) rs3765534 variants suffered from severe leukopenia and required 6-mercaptopurine dose reduction to less than 35 mg/m(2)/da
Current review highlights the scientific data on NUDT15 enzyme variant in patients with acute lymphoblastic leukaemia and its relation to 6-mercaptopurine toxicity in various ethnic populations.
3 novel NUDT15 coding variants (p.R34T, p.K35E, and p.G17_V18del) in 5 children with acute lymphoblastic leukemia enrolled in frontline protocols in Singapore, Taiwan, and at St. Jude Children's Research Hospital.
NUDT15 variant as a predictor for thiopurine-induced toxicity in Indian patients.
NUDT15 gene polymorphism is related to mercaptopurine intolerance in Taiwan Chinese children with acute lymphoblastic leukemia.
our results defined how NUDT15 limits thiopurine efficacy and how genetic ablation via the R139C missense mutation confers sensitivity to thiopurine treatment in patients
NUDT15 polymorphisms are associated with 6-mercaptopurine intolerance in children treated for acute lymphoblastic leukemia.
NUDT15 c.415C>T may be another predictor of AZA-induced leukocytopenia.
our study shows that 6-MP reduction is significant in the younger age group in relation to NUDT15 variant
These results suggest that the MTH2 deficiency might be one of the causative factors for accelerated aging.
MTH2 has a potential to protect the genetic material from the untoward effects of endogenous oxygen radicals; MTH2 could act as an MTH1 (show NUDT1 Proteins) redundancy factor [MTH2]
Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear. May have a role in DNA synthesis and cell cycle progression through the interaction with PCNA.
, 8-oxo-dGTPase NUDT15
, mutT homolog 2
, nucleoside diphosphate-linked moiety X motif 15
, nudix motif 15
, nudix-type motif 15
, probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15
, probable 8-oxo-dGTP diphosphatase NUDT15
, MutT homolog 2