Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1) ELISA Kits

Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. Additionally we are shipping NUDT1 Antibodies (55) and NUDT1 Proteins (17) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
NUDT1 4521 P36639
NUDT1 17766 P53368
NUDT1 117260 P53369
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top NUDT1 ELISA Kits at antibodies-online.com

Showing 3 out of 6 products:

Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
Human 0.469 ng/mL 0.78-50 ng/mL 96 Tests Log in to see 13 to 16 Days
$475.20
Details
Mouse
96 Tests Log in to see 15 to 18 Days
$946.00
Details
Rat
96 Tests Log in to see 15 to 18 Days
$946.00
Details

More ELISA Kits for NUDT1 Interaction Partners

Human Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1) interaction partners

  1. Reduced MUTYH (show MUTYH ELISA Kits), MTH1, and OGG1 (show OGG1 ELISA Kits) expression and TP53 (show TP53 ELISA Kits) mutations occur in diffuse-type adenocarcinoma of gastric cardia.

  2. Analyses of bond lengths with high-resolution X-ray data and the relationship between the structure and enzymatic activity revealed that hMTH1 recognizes the different oxidized nucleotides via an exchange of the protonation state at two neighboring aspartate residues (Asp (show ASIP ELISA Kits)-119 and Asp (show ASIP ELISA Kits)-120) in its substrate binding pocket

  3. MTH1 inhibition may offer a general approach to treat cancers characterized by deregulated hypoxia signaling or redox imbalance

  4. MTH-1 expression in colorectal cancer cells was upregulated via HIF-1alpha (show HIF1A ELISA Kits) in response to hypoxic stress, emphasizing the crucial role of HIF-1alpha (show HIF1A ELISA Kits)-induced MTH-1 in tumor growth.

  5. activity of MTH1 in different breast cancer cell lines has been detected, implying the potential application of this assay method for biomedical research and clinical diagnose in the future

  6. a novel approach involving liquid chromatography-isotope-dilution tandem mass spectrometry to positively identify and accurately quantify MTH1 in human tissues, is reported.

  7. MTH1 is the most prominent sanitizer of the cellular dNTP pool known to date.

  8. MTH1 expression is required for effective transformation of epithelial cells by oncogenic HRAS (show HRAS ELISA Kits).

  9. Results show that MTH1 plays no role in protecting the cells against ultraviolet radiation-induced cytogenetic damage.

  10. Results suggest that the hMTH1-mediated maintenance of mtDNA stability protects cells from the susceptibility to oxidant injury associated with polyQ-expanded Htt (show HTT ELISA Kits), defends against 3-nitropropionic acid-induced neurodegeneration

Mouse (Murine) Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1) interaction partners

  1. These results suggest that MTH1 deficiency might be a causative factor for aging and age-related disorders.

  2. MTH1 protects cells from H2O2-induced cell dysfunction and death by hydrolyzing oxidized purine nucleotides including 8-oxo-dGTP and 2-OH-dATP.

  3. MTH1 efficiently suppresses the accumulation of 8-oxoG in both cellular DNA and RNA in the hippocampus, especially in microglia, caused by excitotoxicity.

NUDT1 Antigen Profile

Antigen Summary

Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.

Gene names and symbols associated with NUDT1

  • 7,8-dihydro-8-oxoguanine triphosphatase (mth1) antibody
  • 7,8-dihydro-8-oxoguanine triphosphatase (Tsp_07498) antibody
  • 7,8-dihydro-8-oxoguanine triphosphatase (8odp) antibody
  • nudix (nucleoside diphosphate linked moiety X)-type motif 1 (NUDT1) antibody
  • nudix (nucleoside diphosphate linked moiety X)-type motif 1 (Nudt1) antibody
  • Mth1 antibody
  • mutT antibody
  • nudT1 antibody

Protein level used designations for NUDT1

7,8-dihydro-8-oxoguanine triphosphatase , 2-hydroxy-dATP diphosphatase , 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase , 8-oxo-7,8-dihydroguanosine triphosphatase , 8-oxo-dGTPase , mutT human homolog 1 , nucleoside diphosphate-linked moiety X motif 1 , nucleoside diphosphate-linked moiety X-type motif 1 , nudix motif 1 , 8-oxo-7,8-dihydro-2'-dGTPase , mutT human homolog (8-oxo-dGTPase) , nudix-type motif 1

GENE ID SPECIES
8791327 Azospirillum sp. B510
10901982 Trichinella spiralis
100195837 Salmo salar
100305248 Oncorhynchus mykiss
4521 Homo sapiens
17766 Mus musculus
117260 Rattus norvegicus
Selected quality suppliers for NUDT1 (NUDT1) ELISA Kits
Did you look for something else?