Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 15 Proteins (NUDT15)

Mediates the hydrolysis of some nucleoside diphosphate derivatives. Additionally we are shipping NUDT15 Antibodies (25) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NUDT15 55270 Q9NV35
NUDT15 214254 Q8BG93
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Top NUDT15 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details

NUDT15 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 15 (NUDT15) Interaction Partners

Human Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 15 (NUDT15) interaction partners

  1. 3 novel NUDT15 coding variants (p.R34T, p.K35E, and p.G17_V18del) in 5 children with acute lymphoblastic leukemia enrolled in frontline protocols in Singapore, Taiwan, and at St. Jude Children's Research Hospital.

  2. NUDT15 variant as a predictor for thiopurine-induced toxicity in Indian patients.

  3. NUDT15 gene polymorphism is related to mercaptopurine intolerance in Taiwan Chinese children with acute lymphoblastic leukemia.

  4. our results defined how NUDT15 limits thiopurine efficacy and how genetic ablation via the R139C missense mutation confers sensitivity to thiopurine treatment in patients

  5. NUDT15 polymorphisms are associated with 6-mercaptopurine intolerance in children treated for acute lymphoblastic leukemia.

  6. NUDT15 c.415C>T may be another predictor of AZA-induced leukocytopenia.

  7. our study shows that 6-MP reduction is significant in the younger age group in relation to NUDT15 variant

  8. Letter: discuss role of NUDT15 in complex thiopurine metabolism.

  9. There was a close association of NUDT15 R139C with early leukopenia associated with thiopurines in patients in Hong Kong

  10. These results suggest that NUDT15 R139C-related thiopurine-induced leukocytopenia is mediated by a 6-TGN (show TG Proteins)-independent mechanism.

Mouse (Murine) Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 15 (NUDT15) interaction partners

  1. These results suggest that the MTH2 deficiency might be one of the causative factors for accelerated aging.

  2. MTH2 has a potential to protect the genetic material from the untoward effects of endogenous oxygen radicals; MTH2 could act as an MTH1 (show NUDT1 Proteins) redundancy factor [MTH2]

NUDT15 Protein Profile

Protein Summary

Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear. May have a role in DNA synthesis and cell cycle progression through the interaction with PCNA.

Gene names and symbols associated with NUDT15

  • nudix (nucleoside diphosphate linked moiety X)-type motif 15 (NUDT15)
  • nudix (nucleoside diphosphate linked moiety X)-type motif 15 (Nudt15)
  • 6530403O17 protein
  • A730068G11Rik protein
  • MTH2 protein
  • RP11-90M2.1 protein

Protein level used designations for NUDT15

7,8-dihydro-8-oxoguanine-triphosphatase NUDT15 , 8-oxo-dGTPase NUDT15 , A730068G11Rik , mutT homolog 2 , nucleoside diphosphate-linked moiety X motif 15 , nudix motif 15 , nudix-type motif 15 , probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15 , probable 8-oxo-dGTP diphosphatase NUDT15 , MutT homolog 2 , mMTH2

GENE ID SPECIES
55270 Homo sapiens
214254 Mus musculus
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