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ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1) ELISA Kits

The protein encoded by ORAI1 is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. Additionally we are shipping ORAI1 Antibodies (127) and and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
ORAI1 84876 Q96D31
ORAI1 109305 Q8BWG9
ORAI1 304496 Q5M848
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Top ORAI1 ELISA Kits at antibodies-online.com

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Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
Rat
96 Tests Log in to see 11 to 13 Days
$875.60
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Human
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$875.60
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Mouse
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$875.60
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Chicken
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$1,095.60
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More ELISA Kits for ORAI1 Interaction Partners

Zebrafish ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1) interaction partners

  1. Orai1 is localized to the cleavage furrow during cytokinesis of the first and second cell division cycles in zebrafish embryos.

  2. The findings identify ORAI1 as an important regulator of cardiac and skeletal muscle function and provide evidence linking ORAI1-mediated calcium signaling to sarcomere integrity and cardiomyocyte function.

Xenopus laevis ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1) interaction partners

  1. The Orai1 actively recycles between an endosomal compartment and the cell membrane through a Rho-dependent endocytic pathway.

Silk Worm ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1) interaction partners

  1. STIM1 (show STIM1 ELISA Kits) and Orai1 are essential components of the signal transduction cascade that regulates sex pheromone production.

Human ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1) interaction partners

  1. Orai1-mediated Ca(2 (show CA2 ELISA Kits)+)-influx and SPCA2 (show ATP2C2 ELISA Kits)-mediated Ca(2 (show CA2 ELISA Kits)+) uptake activity into the Golgi/secretory pathway might be coupled possibly in a microdomain. This channel/pump complex may efficiently transfer Ca(2 (show CA2 ELISA Kits)+) into the secretory pathway, which might play a role in SPCA2 (show ATP2C2 ELISA Kits)-expressing secretory cells, such as mammary gland during lactation.

  2. This study may lay the foundation for finding novel lead compounds for clinical trials that could positively modulate the course of autoimmune disorders with ORAI1 as its specific target.

  3. Mutations in the STIM1 (show STIM1 ELISA Kits) and ORAI1 genes cause calcium dyshomeostasis in tubular aggregate myopathy. (Review)

  4. Results revealed that Orai1-mediated store-operated Ca(2 (show CA2 ELISA Kits)+) entry is critical for gastrointestinal stromal tumor cell proliferation via c-KIT (show KIT ELISA Kits) and ERK (show EPHB2 ELISA Kits) signaling pathway activation.

  5. SARAF (show TMEM66 ELISA Kits) overexpression attenuated store operated Ca2 (show CA2 ELISA Kits)+ entry and the STIM1 (show STIM1 ELISA Kits)-Orai1 interaction in cells endogenously expressing STIM1 (show STIM1 ELISA Kits) and Orai1 while RNAi-mediated SARAF (show TMEM66 ELISA Kits) silencing induced opposite effects.

  6. the STIM1 (show STIM1 ELISA Kits)-Orai1 system has a role in intra-cellular calcium elevation induced by ATP in cultured human keratinocytes

  7. Chorein (show VPS13A ELISA Kits) is a stimulator of Orai1 expression and thus of store operated Ca2 (show CA2 ELISA Kits)+ entry.

  8. Coupling of the endoplasmic reticulum (ER) Ca(2 (show CA2 ELISA Kits)+)sensor, stromal interaction molecule 1 (STIM1 (show STIM1 ELISA Kits)), to the Ca(2 (show CA2 ELISA Kits)+)-selective channel, Orai1, is regulated by these elements and depends on membrane organization, both at the plasma membrane and at the ER

  9. Decreased Orai1 expression was observed in human term-pregnant laboring myometrium compared with non-pregnant myometrium.

  10. identified a Ca(2 (show CA2 ELISA Kits)+)-accumulating region (CAR) in the extracellular opening of Orai1, which explains how concentrating Ca(2 (show CA2 ELISA Kits)+) at the mouth of Orai1 facilitates channel permeation and contributes to selectivity.

Mouse (Murine) ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1) interaction partners

  1. reveal that Orai1 (show TMEM132A ELISA Kits)(-/-) male mice are sterile and have severe defects in spermatogenesis, with prominent deficiencies in mid- to late-stage elongating spermatid development

  2. In Dicer (show DICER1 ELISA Kits)-deficient mice Orai1 (show TMEM132A ELISA Kits) was down-regulated at mRNA and protein level in CD4 (show CD4 ELISA Kits)+ T cells.

  3. results identified the ORAI-NOX2 (show CYBB ELISA Kits) feedback loop as a determinant of monocyte immune responses.

  4. Orai1 (show TMEM132A ELISA Kits)-dependent Ca(2 (show CA2 ELISA Kits)+) entry promotes atherogenesis possibly by promoting foam cell formation and vascular inflammation, rendering orai1 (show TMEM132A ELISA Kits) Ca(2 (show CA2 ELISA Kits)+) channel a potential therapeutic target against atherosclerosis.

  5. alternative translation initiation of the Orai1 (show TMEM132A ELISA Kits) message produces at least three types of Ca(2 (show CA2 ELISA Kits)+) channels with distinct signaling and regulatory properties.

  6. Orai1 (show TMEM132A ELISA Kits) and STIM1 (show STIM1 ELISA Kits) have roles in inhibiting matrix protein expression

  7. SOCE blockers or ablation of STIM1 (show STIM1 ELISA Kits), STIM2 (show Stim2 ELISA Kits), or Orai1 (show TMEM132A ELISA Kits) severely impaired nucleotide-induced migration and phagocytosis in microglia.

  8. Our data establish Orai1 (show TMEM132A ELISA Kits) as key signal mediator of C5aR (show C5AR1 ELISA Kits) activation, contributing to inflammation

  9. Orai1 (show TMEM132A ELISA Kits) store-operated calcium channels have an essential role in lactation

  10. TRPC6 (show TRPC6 ELISA Kits) activity can occur independently of the physical interaction with Orai1 (show TMEM132A ELISA Kits)

ORAI1 Antigen Profile

Antigen Summary

The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1).

Gene names and symbols associated with ORAI1

  • ORAI calcium release-activated calcium modulator 1b (orai1b) antibody
  • ORAI calcium release-activated calcium modulator 1 (orai1) antibody
  • ORAI calcium release-activated calcium modulator 1 (ORAI1) antibody
  • ORAI calcium release-activated calcium modulator 1 (Orai1) antibody
  • ORAI calcium release-activated calcium modulator 1 (LOC100218031) antibody
  • ORAI calcium release-activated calcium modulator 2 (orai2) antibody
  • CRACM1 antibody
  • D730049H07Rik antibody
  • im:7146264 antibody
  • LOC100218031 antibody
  • orai-1 antibody
  • ORAI1 antibody
  • orai2 antibody
  • ORAT1 antibody
  • RGD1311873 antibody
  • Tmem142a antibody
  • tmem142b antibody
  • zgc:109721 antibody

Protein level used designations for ORAI1

ORAI calcium release-activated calcium modulator 1 , calcium release-activated calcium channel protein 1 , protein orai-1 , transmembrane protein 142A , protein orai-2 , transmembrane protein 142B , calcium release-activated calcium modulator 1 , calcium release-activated calcium channel 1

GENE ID SPECIES
402892 Danio rerio
403390 Xenopus laevis
473293 Pan troglodytes
700190 Macaca mulatta
100125061 Xenopus (Silurana) tropicalis
100188931 Bombyx mori
100218031 Taeniopygia guttata
84876 Homo sapiens
486261 Canis lupus familiaris
100154923 Sus scrofa
517688 Bos taurus
109305 Mus musculus
304496 Rattus norvegicus
416845 Gallus gallus
734537 Xenopus laevis
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